Tailored Nanoparticles by Wet Chemical Particle Technology

Flegler, Andreas; Wintzheimer, Susanne; Schneider, Michael; Gellermann, Carsten; Mandel, Karl

doi:10.1016/b978-0-12-813351-4.00007-9

Cited by 8 publications

(6 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One may notice a deficit of simple industrial procedures for the synthesis of nanomaterials regarding the limited possibilities of the industrial plant. 199 Methods for the synthesis of nanomaterials described in the literature have many limitations, such as the difficult removal of a toxic organic solvent (in solvent emulsification-diffusion technique applied to lipids) or challenging maintaining sterility of the product. 185 , 191 , 200 Furthermore, some methods to produce nanoformulations, such as freeze-drying and spray-drying used to fabricate nanoencapsulates in powder form, are expensive and may affect particle size.…”

Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

“…Furthermore, as usually creating a new drug delivery system is a reformulation of a previously known drug, pharmaceutical companies often do not consider this process worth the time and costs compared to profits and prefer investing in the search for new drugs by simply screening libraries of small compounds. 188 , 199 …”

Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

“…191,192 Furthermore, as usually creating a new drug delivery system is a reformulation of a previously known drug, pharmaceutical companies often do not consider this process worth the time and costs compared to profits and prefer investing in the search for new drugs by simply screening libraries of small compounds. 188,199 Green Synthesis in Drug Carriers Manufacturing "Green nanomedicine" is a new field of drug delivery systems based on nanomaterials, which provides tools for more economical nanocarriers synthesis. However, currently, only a few literature examples of research can be found in which at least a few of the dozen "green chemistry" postulates have been met.…”

Section: Primary Outcome Measuresmentioning

confidence: 99%

See 2 more Smart Citations

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Milewska¹,

Niemirowicz-Laskowska²,

Siemiaszko³

et al. 2021

IJN

View full text Add to dashboard Cite

Nanotherapy is a part of nanomedicine that involves nanoparticles as carriers to deliver drugs to target locations. This novel targeting approach has been found to resolve various problems, especially those associated with cancer treatment. In nanotherapy, the carrier plays a crucial role in handling many of the existing challenges, including drug protection before early-stage degradations of active substances, allowing them to reach targeted cells and overcome cell resistance mechanisms. The present review comprises the following sections: the first part presents the introduction of pharmacoeconomics as a branch of healthcare economics, the second part covers various beneficial aspects of the use of nanocarriers for in vitro, in vivo, and pre- and clinical studies, as well as discussion on drug resistance problem and present solutions to overcome it. In the third part, progress in drug manufacturing and optimization of the process of nanoparticle synthesis were discussed. Finally, pharmacokinetic and toxicological properties of nanoformulations due to up-to-date studies were summarized. In this review, the most recent developments in the field of nanotechnology’s economic impact, particularly beneficial applications in medicine were presented. Primarily focus on cancer treatment, but also discussion on other fields of application, which are strongly associated with cancer epidemiology and treatment, was made. In addition, the current limitations of nanomedicine and its huge potential to improve and develop the health care system were presented.

show abstract

Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

Section: Business Criteria For the Development Of Drug Carriersmentioning

confidence: 99%

Section: Primary Outcome Measuresmentioning

confidence: 99%

See 1 more Smart Citation

Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment

Milewska¹,

Niemirowicz-Laskowska²,

Siemiaszko³

et al. 2021

IJN

View full text Add to dashboard Cite

show abstract

“…As a more detailed outline of this issue would be beyond the scope of this article, the interested reader is referred to a detailed discussion on this issue, which was recently published by us. 27 …”

mentioning

confidence: 99%

Supraparticles with silica protection for redispersible, calcined nanoparticles

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“… 34 However, the entire core–shell structures have still diameters of just a few nanometres and therefore the issues regarding handling, separation and upscaling remain. 35 …”

mentioning

confidence: 99%