Tailored mechanosensitive nanogels release drugs upon exposure to different levels of stenosis

Abstract

Owing to the unhealthy lifestyle and genetic susceptibility of today’s population, atherosclerosis is one of the global leading causes of life-threatening cardiovascular diseases. Although a rapid intervention is required for...

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

“…demonstrated the sensitivity of nanogels containing different poly(ethylene glycol) diacrylate concentrations to different shear stress levels. [ 133 ] Similarly, simvastatin acid (SA)‐loaded cross‐linked dendrimer nanoparticles (SA PAM) were created by Shen et al. and attached to the surfaces of RBCs resulting in the formation of SA PAM@RBCs.…”

“…Kimna et al demonstrated the sensitivity of nanogels containing different poly(ethylene glycol) diacrylate concentrations to different shear stress levels. [133] Similarly, simvastatin acid (SA)-loaded cross-linked dendrimer nanoparticles (SA PAM) were created by Shen et al and attached to the surfaces of RBCs resulting in the formation of SA PAM@RBCs. [134] While 61.3% of the SA PAM desorbed from RBCs in response to a high shear stress stimulus (100 dynes per cm 2 ), only 12.4% detached from RBCs under low shear stress (20 dynes per cm 2 ).…”

“…B) Nanogel behavior under different mechanical loads. Reproduced with permission [133]. Copyright 2021, Royal Society of Chemistry.…”