Tailored mechanical response and mass transport characteristic of selective laser melted porous metallic biomaterials for bone scaffolds

Zhang, Lei; Song, Bo; Liu, Yang; Shi, Yusheng

doi:10.1016/j.actbio.2020.05.038

Cited by 91 publications

(24 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[35] Mechanical property and permeability are two important factors revealing the biomimetically hierarchical structure of scaffolds and thus, influencing the performance of bone implants in vivo. [36] To investigate the relationship among mechanical property, permeability, and pore size, three kinds of DMGP scaffolds with different pore sizes were successfully fabricated. Compression test results showed that stress-strain curves from different samples followed a similar trend (Figure S6A, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration

et al. 2022

View full text Add to dashboard Cite

Engineering a proper immune response following biomaterial implantation is essential to bone tissue regeneration. Herein, a biomimetically hierarchical scaffold composed of deferoxamine@poly(ε‐caprolactone) nanoparticles (DFO@PCL NPs), manganese carbonyl (MnCO) nanosheets, gelatin methacryloyl hydrogel, and a polylactide/hydroxyapatite (HA) matrix is fabricated to augment bone repair by facilitating the balance of the immune system and bone metabolism. First, a 3D printed stiff scaffold with a well‐organized gradient structure mimics the cortical and cancellous bone tissues; meanwhile, an inside infusion of a soft hydrogel further endows the scaffold with characteristics of the extracellular matrix. A Fenton‐like reaction between MnCO and endogenous hydrogen peroxide generated at the implant‐tissue site triggers continuous release of carbon monoxide and Mn2+, thus significantly lessening inflammatory response by upregulating the M2 phenotype of macrophages, which also secretes vascular endothelial growth factor to induce vascular formation. Through activating the hypoxia‐inducible factor‐1α pathway, Mn2+ and DFO@PCL NP further promote angiogenesis. Moreover, DFO inhibits osteoclast differentiation and synergistically collaborates with the osteoinductive activity of HA. Based on amounts of data in vitro and in vivo, strong immunomodulatory, intensive angiogenic, weak osteoclastogenic, and superior osteogenic abilities of such an osteoimmunity‐regulating scaffold present a profound effect on improving bone regeneration, which puts forward a worthy base and positive enlightenment for large‐scale bone defect repair.

show abstract

Section: Resultsmentioning

confidence: 99%

Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The internal pore structure is very important for the infiltration, proliferation, differentiation and migration of cells [2,3]. A large area of bone defect in human body needs external intervention [4]. Autografts and allografts are the common treatment of clinical bone defect diseases [5,6].…”

Section: Introductionmentioning

confidence: 99%

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Shi

Qin

et al. 2021

PLoS ONE

View full text Add to dashboard Cite

In this paper, we take the elliptical pore structure which is similar to the microstructure of cancellous bone as the research object, four groups of bone scaffolds were designed from the perspective of pore size, porosity and pore distribution. The size of the all scaffolds were uniformly designed as 10 × 10 × 12 mm. Four groups of model samples were prepared by selective laser melting (SLM) and Ti6Al4V materials. The statics performance of the scaffolds was comprehensively evaluated by mechanical compression simulation and mechanical compression test, the manufacturing error of the scaffold samples were evaluated by scanning electron microscope (SEM), and the permeability of the scaffolds were predicted and evaluated by simulation analysis of computational fluid dynamics (CFD). The results show that the different distribution of porosity, pore size and pores of the elliptical scaffold have a certain influence on the mechanical properties and permeability of the scaffold, and the reasonable size and angle distribution of the elliptical pore can match the mechanical properties and permeability of the elliptical pore scaffold with human cancellous bone, which has great potential for research and application in the field of artificial bone scaffold.

show abstract

“…Inspired by the spongy structure of cancellous bones with porosities of 50~90%, artificial bone scaffolds should possess three-dimensional macropores supporting nutrient transport and bone tissue in-growth 38 . The pure CS porous scaffolds showed the ductile feature, easily leading to the failure of macropore structure 16 , 39 . Interestingly, the incorporation of LDH, La1/7-LDH or La1/4-LDH nanoplates within the CS scaffolds improved the mechanical property of organic/inorganic scaffolds (Figure 3 B).…”

Section: Resultsmentioning

confidence: 99%

Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration

et al. 2021

View full text Add to dashboard Cite

Rationale: Osteoporotic patients suffer symptoms of excessive osteoclastogenesis and impaired osteogenesis, resulting in a great challenge to treat osteoporosis-related bone defects. Based on the positive effect of rare earth elements on bone metabolism and bone regeneration, we try to prove the hypothesis that the La 3+ dopants in lanthanum-substituted MgAl layered double hydroxide (La-LDH) nanohybrid scaffolds simultaneously activate osteogenesis and inhibit osteoclastogenesis. Methods: A freeze-drying technology was employed to construct La-LDH nanohybrid scaffolds. The in vitro osteogenic and anti-osteoclastogenic activities of La-LDH nanohybrid scaffolds were evaluated by using ovariectomized rat bone marrow stromal cells (rBMSCs-OVX) and bone marrow-derived macrophages (BMMs) as cell models. The in vivo bone regeneration ability of the scaffolds was investigated by using critical-size calvarial bone defect model of OVX rats. Results: La-LDH nanohybrid scaffolds exhibited three-dimensional macroporous structure, and La-LDH nanoplates arranged perpendicularly on chitosan organic matrix. The La 3+ dopants in the scaffolds promote proliferation and osteogenic differentiation of rBMSCs-OVX by activating Wnt/β-catenin pathway, leading to high expression of ALP, Runx-2, COL-1 and OCN genes. Moreover, La-LDH scaffolds significantly suppressed RANKL-induced osteoclastogenesis by inhibiting NF-κB signaling pathway. As compared with the scaffolds without La 3+ dopants, La-LDH scaffolds provided more favourable microenvironment to induce new bone in-growth along macroporous channels. Conclusion: La-LDH nanohybrid scaffolds possessed the bi-directional regulation functions on osteogenesis and osteoclastogenesis for osteoporotic bone regeneration. The modification of La 3+ dopants in bone scaffolds provides a novel strategy for osteoporosis-related bone defect healing.

show abstract

Tailored mechanical response and mass transport characteristic of selective laser melted porous metallic biomaterials for bone scaffolds

Cited by 91 publications

References 76 publications

Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration

Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration

Contact Info

Product

Resources

About