Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances

Holá, Kateřina; Markova, Z.A.; Zoppellaro, Giorgio; Tuček, Jiří; Zbořil, Radek

doi:10.1016/j.biotechadv.2015.02.003

Cited by 313 publications

(157 citation statements)

References 156 publications

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“…The chemical coprecipitation of Fe (III) and Fe (II) salts in alkaline solutions was used as a traditional method of preparing Fe 3 NPs was about 5-10 nm, which was smaller than the traditional method. The addition of the PCA-PEG-PCA with a hyperbranch structure during the reaction process provided steric repulsion to improve the quality of the dispersion of particles (4).…”

Section: Resultsmentioning

confidence: 99%

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

Zarnegar

Safari

2017

Green Chemistry Letters and Reviews

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In this investigation, magnetite nanoparticles (Fe 3 O 4 NPs) with a diameter of 5-10 nm were synthesized by coprecipitation from an alkaline solution of ferrous/ferric mixed salt-solution in the presence of copolymers. In this process, linear-dendritic copolymers containing a linear poly (ethylene glycol) core and dendritic poly (citric acid) arms were used as the stabilizer. The Fe 3 O 4 NPs were characterized by transmission electron microscopy, energy-dispersive spectra, X-ray powder diffraction, field emission scanning electron microscopy, Fourier transform infrared spectrometer, and vibrating sample magnetometer. Compared to classical coprecipitation, the results showed that uniform, ultrafine, nearly spherical, and high purity nano-magnetite particles with better magnetic properties could be prepared by this method. ARTICLE HISTORY

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Section: Resultsmentioning

confidence: 99%

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

Zarnegar

Safari

2017

Green Chemistry Letters and Reviews

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“…The major areas of applications of SPIONs are found to include, targeted drug delivery [147][148] , anti-cancer therapy [149][150] , diagnosis and treatment of cancer 151 , contrast agent in medical imaging 153 , tissue engineering, target liver tumours and metastasis, ultra-sensitive molecular imaging, cancer treatment by hyperthermia 154 , antimicrobial activities [155][156] , biosensors & intracellular analysis 157 and photothermal cancer therapy [158][159] . The unique properties of iron oxide magnetic nanoparticles are suitable for using in biocatalysis and bioseparation areas 160 .…”

Section: Biomedical Applications Of Iron Oxide Npsmentioning

confidence: 99%

Untitled

2017

IJPSR

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Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic applications.

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“…On the other hand, numerous therapeutic applications of MNPs have been widely investigated during the last decades. Thermal ablation and hyperthermia, [26] targetable drug delivery, [27] tissue engineering, [28] gene delivery (transfection), [29] cell or DNA purification and separation [30] are of some most important therapeutic applications facilitated by the novel MNP theranostic agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

187

169

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances

Cited by 313 publications

References 156 publications

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

Modified chemical coprecipitation of magnetic magnetite nanoparticles using linear–dendritic copolymers

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Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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