Tailored Functional Surfaces Using Nanoparticle and Protein “Nanobrick” Coatings

Wang, Lisheng; Gopalakrishnan, S.; Rotello, Vincent M.

doi:10.1021/acs.langmuir.8b03235

Cited by 8 publications

(9 citation statements)

References 95 publications

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“…The coated surface can then be functionalized with various moieties such as chlorinating agents to produce N - or S -chloro species that would slowly release chlorine, providing a strong biocidal activity against uropathogens in addition to antifouling properties . These protein coatings were also combined with nanoparticles as a nanobrick surface modification technique to create thin-film coatings on various substrates such as dental implant screws for biomedical applications. , Such robust approaches can be utilized toward scaling of medical device technology with protein films with an ability to be thermally treated to produce biostable coatings that retain their surface architecture ( i.e. , hydrophilicity, biodegradability, surface charges, etc. )…”

Section: Antimicrobial Surfaces With Dual Antibacterial and Antifouli...mentioning

confidence: 99%

“…84 These protein coatings were also combined with nanoparticles as a nanobrick surface modification technique to create thin-film coatings on various substrates such as dental implant screws for biomedical applications. 85,86 Such robust approaches can be utilized toward scaling of medical device technology with protein films with an ability to be thermally treated to produce biostable coatings that retain their surface architecture (i.e., hydrophilicity, biodegradability, surface charges, etc.) in an in vivo environment.…”

Section: Surface Passivation Via Protein Coatingsmentioning

confidence: 99%

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Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Chug

Brisbois

2022

ACS Mater. Au

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Implant-associated infections arising from biofilm development are known to have detrimental effects with compromised quality of life for the patients, implying a progressing issue in healthcare. It has been a struggle for more than 50 years for the biomaterials field to achieve long-term success of medical implants by discouraging bacterial and protein adhesion without adversely affecting the surrounding tissue and cell functions. However, the rate of infections associated with medical devices is continuously escalating because of the intricate nature of bacterial biofilms, antibiotic resistance, and the lack of ability of monofunctional antibacterial materials to prevent the colonization of bacteria on the device surface. For this reason, many current strategies are focused on the development of novel antibacterial surfaces with dual antimicrobial functionality. These surfaces are based on the combination of two components into one system that can eradicate attached bacteria (antibiotics, peptides, nitric oxide, ammonium salts, light, etc.) and also resist or release adhesion of bacteria (hydrophilic polymers, zwitterionic, antiadhesive, topography, bioinspired surfaces, etc.). This review aims to outline the progress made in the field of biomedical engineering and biomaterials for the development of multifunctional antibacterial biomedical devices. Additionally, principles for material design and fabrication are highlighted using characteristic examples, with a special focus on combinational nitric oxide-releasing biomedical interfaces. A brief perspective on future research directions for engineering of dual-function antibacterial surfaces is also presented.

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Section: Antimicrobial Surfaces With Dual Antibacterial and Antifouli...mentioning

confidence: 99%

Section: Surface Passivation Via Protein Coatingsmentioning

confidence: 99%

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Chug

Brisbois

2022

ACS Mater. Au

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“…but also their uniformity in the molecular structure and precisely located chemical groups. 8 Benefiting from the luxury functions of proteins, protein coatings produced by fixing proteins onto the surfaces of various substrates have extended the applications of proteins to tissue engineering scaffolds, 9 drug delivery, 10 antimicrobials, 11 sensing and diagnostic equipment, 12 food packaging, 13 etc., which has stimulated strategies for generating protein coatings. 14 Accumulating evidence has shown that the conformation of the incorporated protein in protein coatings has a profound influence on not only native functionalities but also the mechanical strength, stability, and bioadhesion of the coatings.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In materials science, proteins are considered one of the paramount building blocks due to not only their plentiful functions (catalysis, cellular signal transduction, etc.) but also their uniformity in the molecular structure and precisely located chemical groups . Benefiting from the luxury functions of proteins, protein coatings produced by fixing proteins onto the surfaces of various substrates have extended the applications of proteins to tissue engineering scaffolds, drug delivery, antimicrobials, sensing and diagnostic equipment, food packaging, etc., which has stimulated strategies for generating protein coatings .…”

Section: Introductionmentioning

confidence: 99%

Secondary Structure-Dominated Layer-by-Layer Growth Mode of Protein Coatings

Zhang

Cheng

et al. 2021

Langmuir

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Benefiting from the luxury functions of proteins, protein coatings have been extended to various applications, including tissue engineering scaffolds, drug delivery, antimicrobials, sensing and diagnostic equipment, food packaging, etc. Fast construction of protein coatings is always interesting to materials science and significant to industrialization. Here, we report a layerby-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating. As well characterized by various techniques (quartz crystal microbalance with dissipation (QCM-D), circular dichroism (CD) spectra, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), contact angle, etc.), TA-induced conformational transition of Lyz to α-helices occurs at pH 8 from other secondary structures (β-sheets, β-turns, and random coils), which leads to the very fast growth of TA/Lyz with a number of deposited bilayers, with thicknesses of more than 90 nm for six bilayers. In contrast to the leading conformation of α-helices at pH 8, Lyz displayed multiple conformations (α-helices, β-sheets, β-turns, and random coils) at pH 6, which resulted in coating thicknesses of less than 30 nm for six bilayers. By the addition of NaCl, Tween 20, and urea, we further confirmed that the secondary conformations of Lyz relied greatly on the interactions between TA and Lyz and dominated the growth rate of the multilayers. We believe that these findings will help to understand the transformation of secondary conformations by TA or other polyphenols and inspire a new route to quickly build protein coatings.

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“…Proteins are sustainable, biocompatible and biodegradable building blocks for designing materials. [ 1,2 ] Proteins naturally feature a variety of functionalities – for instance, structural proteins like collagen are widely used in biomedical applications due to their abundance in the extracellular matrix. [ 3 ] Silk fibroin and soy protein isolate films have been used as food packaging materials [ 4,5 ] as well as in the fabrication of medical devices, [ 6,7 ] due to their ready availability, efficient processability, biodegradability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Strategies for Fabricating Protein Films for Biomaterial Applications

Gopalakrishnan

Zhong

et al. 2020

Advanced Sustainable Systems

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Proteins are naturally occurring functional building blocks that are useful for the fabrication of materials. Naturally‐occurring proteins are biodegradable and most are biocompatible and nontoxic, making them attractive for the fabrication of biomaterials. Moreover, the fabrication of protein‐based materials can be conducted in a green and sustainable manner due to their high aqueous solubility. Consequently, the applicability of protein‐based materials is limited by their aqueous and mechanical instability. This review summarizes strategies for the stabilization of protein films, highlighting their salient features and potential limitations. Applications of protein films ranging from food packaging materials, tissue engineering scaffolds, antimicrobial coatings etc. are also discussed. Finally, the need for robust and efficient fabrication strategies for translation to commercial applications as well as potential applications of protein films in the field of sensing, diagnostics, and controlled release systems are discussed.

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Tailored Functional Surfaces Using Nanoparticle and Protein “Nanobrick” Coatings

Cited by 8 publications

References 95 publications

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Secondary Structure-Dominated Layer-by-Layer Growth Mode of Protein Coatings

Strategies for Fabricating Protein Films for Biomaterial Applications

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