Tailored design of electrospun composite nanofibers with staged release of multiple angiogenic growth factors for chronic wound healing

Stem Cell and Stem Cell-Derived Molecular Therapies to Enhance Dermal Wound Healing

“…In a recent study, Lai et al developed an electrospun composite scaffold as a multifactor delivery system. Growth factor encapsulation in the collagen and hyaluronic acid nanofi bers or within gelatin nanoparticles embedded within the nanofi ber matrix enabled the controlled, stagewise release of up to four growth factors [ 150 ]. When applied to wounds of diabetic rats, the nanostructured delivery platform improved wound healing, as shown by the accelerated wound closure, increased collagen deposition, and increased vascularization [ 150 ].…”

“…Growth factor encapsulation in the collagen and hyaluronic acid nanofi bers or within gelatin nanoparticles embedded within the nanofi ber matrix enabled the controlled, stagewise release of up to four growth factors [ 150 ]. When applied to wounds of diabetic rats, the nanostructured delivery platform improved wound healing, as shown by the accelerated wound closure, increased collagen deposition, and increased vascularization [ 150 ]. While not directly aimed at improving endogenous stem cell recruitment, this study illustrates the versatility of nanofi ber and nanoparticle scaffolds as growth factors delivery platforms and their potential for improving molecular therapies aimed at enhancing endogenous stem cell recruitment.…”

Drug Delivery Systems for Wound Healing

“…Accelerated wound closure, increased collagen deposition and improved angiogenesis were all observed when the scaffolds were implanted in excisional wounds on diabetic rats [91]. Complex scaffolds with their own functionality have also been developed to compliment the delivery of a single factor.…”

Biomaterials for Promoting Wound Healing in Diabetes

“…Usually they are engineered to resemble the extracellular matrix of natural soft tissues [14]. These biomaterials can be prepared as high-water-content hydrogels, sponge and patch structures or other architectures, processed by crosslinking, dehydration or freeze drying and electrospinning technique, respectively [15][16][17].…”