Tailored Chiral Copper Selenide Nanochannels for Ultrasensitive Enantioselective Recognition and Detection

Abstract

We constructed at ailorable membrane channel system consisting of penicillamine molecules intercalated in copper selenide nanoparticles (Cu 2Àx Se NPs), which exhibited circular dichroism (CD) bands in the near infrared region (CD,8 00-1600 nm) with am aximum intensity of 164.5 mdeg at 1440 nm. The chiral ligand hybridized to the surface of achiral Cu 2Àx Se NPs by breaking the intrinsic symmetry of Cu 2Àx Se NPs and further large-scale assembly induced strong optical activity.T he fabricated multilayer chiral membrane achieved an increased rectification ratio (RR) up to 114. The integration of penicillamine allowed for high enantioselective recognition against naproxen,which displayed high sensitivity with alimit of detection (LOD) as low as 0.027 nM.

Recent Advances in Separation and Analysis of Chiral Compounds

“…These materials have abundant ordered channels with diameters ranging from nano-to micrometers. 168,169 Microchannel membranes with relatively large channel size are adapted to high flux, but the enantioselective separation in the channels need specific design. Feng and Zhang et al 170 incorporated chiral gold nanoparticles into a microchannel polycarbonate membrane to astringe the large pores and improve the enantioselectivity.…”

“…Micro/nanochannel membranes based on polymer and inorganic materials were prepared on a large scale as separation membranes. These materials have abundant ordered channels with diameters ranging from nano- to micrometers. , Microchannel membranes with relatively large channel size are adapted to high flux, but the enantioselective separation in the channels need specific design. Feng and Zhang et al .…”

Chiral nanomaterials for biosensing, bioimaging, and disease therapies

“…83 As reported by our team, a copper selenide (Cu 2− x Se)-NP-constituted chiral 2D membrane has been investigated for the enantioselective recognition of a naproxen substrate. 84 It must be noted that achiral Cu 2− x Se NPs that were hybridized with chiral penicillamine molecules showed poor CD intensity, but after the membrane channel system had formed by self-assembly, the optical activity was markedly improved. Researchers explained that the broken intrinsic symmetry of Cu 2− x Se and the collective enhancement of the broad-scale assembly yielded stronger CD signals.…”

Facile one pot synthesis of highly photoresponsive coinage metal selenides (Cu1.8Se and Ag2Se) achieved through novel Cu and Ag pyridylselenolates as molecular precursors

“…10,11 Coinage metal chalcogenides, in their nano-form, have also emerged as potential candidates for new-generation energy storage devices 12,13 and biomedical applications. 14,15 Owing to the multi-dimensional applications of coinage metal chalcogenides, several synthetic protocols have been adopted to access these materials. Among them, solution phase soft chemical routes to nanocrystals exhibit many distinct advantages over traditional ceramic routes such as lower † Electronic supplementary information (ESI) available: Additional figures etc.…”

“…10,11 Coinage metal chalcogenides, in their nano-form, have also emerged as potential candidates for new-generation energy storage devices 12,13 and biomedical applications. 14,15…”