Tailor-made natural deep eutectic solvents for green extraction of isoflavones from chickpea (Cicer arietinum L.) sprouts

Shang, Xingfu; Yuqing, Dou; Zhang, Yingjie; Tan, Jia‐Neng; Liu, Xinmin; Zhang, Zhongfeng

doi:10.1016/j.indcrop.2019.111724

Cited by 90 publications

(48 citation statements)

References 47 publications

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“…Although, in general, increased temperature may contribute in achieving higher extraction yields, it is not a universal rule that temperature rising generates proportional effect on the extraction yield and antioxidant activity. This argument may be exemplified by results drawn from the extraction of various plant materials, including Moringa oleifera leaves [23], onion solid wastes [32,33], chickpea sprouts [34] and red grape pomace [35]. This being the case, the investigation of the effect of temperature on the extraction yield and the antioxidant activity of the extracts merits particular attention.…”

Section: Temperature Effectsmentioning

confidence: 99%

A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment

et al. 2020

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Sambucus nigra flowers, known as elderberry flowers (EBF), are a plant tissue rich in polyphenolic phytochemicals with important bioactivities. However, there are few studies dealing with the production of polyphenol-containing EBF extracts. The objective of the investigation presented herein was the development of a high-performance green extraction methodology, to generate EBF extracts enriched in polyphenolic substances, using an efficient deep eutectic solvent, combined with ultrasonication pretreatment. The DES was composed of L-lactic acid (hydrogen bond donor—HBD) and glycine (hydrogen bond acceptor—HBA) and, after an initial screening to properly regulate HBD/HBA ratio, the extraction was optimized by deploying response surface methodology. Under the optimized conditions, which were DES/water (85% w/v), liquid-to-solid ratio 60 mL g−1, and stirring speed 200 rounds per minute, the extraction yield in total polyphenols amounted to 121.24 ± 8.77 mg gallic acid equivalents per g dry matter. The integration of ultrasonication prior to the batch stirred-tank extraction boosted polyphenol recovery of up to 174.73 ± 2.62 mg gallic acid equivalents per g dry matter. Liquid chromatography–mass spectrometry analysis showed that the richest EBF extract obtained was dominated by rutin, a di-p-coumaroylquic acid and chlorogenic acid.

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Section: Temperature Effectsmentioning

confidence: 99%

A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment

et al. 2020

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“…The issue related with the effect of temperature on the extraction performance has been a subject of several studies, which yielded contradictory results. In general, polyphenols are considered thermolabile substances and temperatures above 60-70 • C might not favor increased extraction yield [28,29]. However, this is not always the case, and other investigations demonstrated that extraction carried out up to 80 • C might provide extracts with higher polyphenol concentration and improved antioxidant characteristics [30,31].…”

Section: Temperature Effectsmentioning

confidence: 99%

Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

et al. 2020

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Olive leaves (OLL) are considered to be a highly appreciated bioresource of bioactive polyphenolic phytochemicals, embracing several different structures. However, extraction processes based on deep eutectic solvents (DES) are very limited despite the wide range of techniques developed for the efficient recovery of polyphenols. This study had as objective the development of a simple, green, high-performance extraction methodology for OLL polyphenols, using a recently reported effective DES, composed of L-lactic acid and glycine. Initially, a screening was performed to select the most appropriate L-lactic/glycine molar ratio and process optimization was then carried out with response surface methodology. The optimized process variable values were DES/water (78% w/v), liquid-to-solid ratio of 36 mL g−1, and stirring speed of 500 rounds per minute, and the total polyphenol yield amounted to 97.53 ± 3.54 mg gallic acid equivalents per g dry matter. Extraction with DES at 80 °C did not significantly increase the total polyphenol yield, but it did enhance the total flavonoid yield and antioxidant activity. High-performance liquid chromatography analyses revealed that extraction with the DES resulted in extended oleuropein hydrolysis, to the favor of hydroxytyrosol formation. This finding might have a prospect in using properly tuned DES for polyphenol modification with improved bioactivities.

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“…At these experimental points, the viscosity was very low, indicating that the DES might lose its intrinsic characteristics and become a simple aqueous solution. It has been reported that a very low viscosity induce less hydrogen-bonding and decrease the extraction yield of phytochemical compounds [37,62]. The highest values were detected in the runs where DES did not require additional water.…”

Section: Model Analysismentioning

confidence: 93%

“…0% additional water at the maximum response values might be explained because the DESs used in the present study were prepared as molarity terms. The hydrophilic DESs are greatly recommended for the isolation of bioactive compounds, facilitating their diffusion and solubility [61,62]. SAFA m was yet hydrophilic, implying that the further addition of water could be harmful to the DES and decrease the extraction performance.…”

Section: Model Analysismentioning

confidence: 99%

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Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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: Deep eutectic solvents (DESs) have got huge interest as new green and sustainable solvents for the extraction of bioactive compounds from plants in recent decades. In the present study, we aimed to investigate the effectiveness of hydrophilic DES for the extraction of anthocyanin and polyphenol antioxidants from Roselle. A natural hydrophilic DES constituted of sodium acetate (hydrogen bond acceptor) and formic acid (hydrogen bond donor) designed to evaluate the total phenolic compound (TPC), total flavonoid (TFC), total anthocyanin (TACN), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) values of Roselle. Distilled water, 70% ethanol, and 80% methanol used as conventional solvents for comparison. The results indicated that the DES prepared in molarity ratio (SAFAm) was the most efficient. Subsequently, this prominent DES selected for the optimization and the optimum extraction conditions were 1:3.6 molarity ratio, 0% additional water, and 10 mL solvent. TPC, TFC, TACN, FRAP, and DPPH radical scavenging at the optimum point were 233.26 mg GAE/g, 10.14 mg ECE/g, 10.62 mg D3S/g, 493.45 mmol ISE/g, and 343.41 mmol TE/g, respectively. The stability tests showed that anthocyanins were more stable in SAFAm. These findings revealed that SAFAm is an effective green solvent for the extraction of polyphenols from various plants.

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Tailor-made natural deep eutectic solvents for green extraction of isoflavones from chickpea (Cicer arietinum L.) sprouts

Cited by 90 publications

References 47 publications

A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment

A Green Extraction Process for Polyphenols from Elderberry (Sambucus nigra) Flowers Using Deep Eutectic Solvent and Ultrasound-Assisted Pretreatment

Green Valorization of Olive Leaves to Produce Polyphenol-Enriched Extracts Using an Environmentally Benign Deep Eutectic Solvent

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

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