Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry

Weyell, Peter; Beekmann, Uwe; Küpper, Christine; Dederichs, Marco; Thamm, Jana; Fischer, Dagmar; Kralisch, Dana

doi:10.1016/j.carbpol.2018.11.061

Cited by 85 publications

(41 citation statements)

References 42 publications

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“…Other studies highlight the potential of BNC as substrate for in vitro models 25 and as a drug delivery matrix. 26,27 Despite these promising reports, the capability of BNC to heal other body surfaces such as the cornea or the dura mater 28 remain largely unexploited. 29 Therefore, based on the outstanding performance of BNC on skin wound healing, we hypothesize that BNC also holds potential as an ocular surface bandage.…”

Section: Introductionmentioning

confidence: 99%

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

et al. 2020

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“…For dental extraction and mucosal transplantation applications, bioabsorbability under physiological conditions and antibiotic loading are desirable. In this context, Weyell et al . studied the degradation and doxycycline release from BC membranes with different oxidation degrees.…”

Section: Applicationsmentioning

confidence: 99%

“…As a result of its self‐attachment to surfaces, flexibility, and softness, BC can also be a good candidate in other dental medicine applications, such as temporal implant in dental extraction alveoli or wound dressing after mucosal implantation . However, although the recognized improved epithelialization and decreased inflammatory reactions during the use of BC‐based periodontal dressing materials, the number of studies of its application in this area is scarce.…”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

121

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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“…An in vitro toxicity test ensured biocompatibility of oxidized BC, whereas agar diffusion tests of samples loaded with doxycycline against pathogenic oral bacteria proved high antibiotic efficiency. Release studies of the drug from native and oxidized BC confirmed a comparable release behavior showing an initial burst of 50-60% within the first hour and a total release of about 90% after 3-5 h [119].…”

Section: Stomatologymentioning

confidence: 60%

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Antón-Sales

Beekmann

Laromaine

et al. 2019

CDT

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In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Because of their continuous exposure to environmental stressors, damage to epithelial tissues is highly prevalent. Here, we first compare the properties of bacterial cellulose to the current gold standard, collagen, and then we examine the use of bacterial cellulose patches to heal specific epithelial tissues; the outer skin, the ocular surface, the oral mucosa and other epithelial surfaces. Special emphasis is made on the dermis since, to date, this is the most widespread medical use of bacterial cellulose. It is important to note that some epithelial tissues represent only the outermost layer of more complex structures such as the skin or the cornea. In these situations, depending on the penetration of the lesion, bacterial cellulose might also be involved in the regeneration of, for instance, inner connective tissue.

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Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry

Cited by 85 publications

References 42 publications

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

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