Tailor-made hydrophobic deep eutectic solvents for cleaner extraction of polyprenyl acetates from Ginkgo biloba leaves

Cao, Jun; Yang, Meng; Cao, Fuliang; Wang, Jiahong; Su, Erzheng

doi:10.1016/j.jclepro.2017.03.140

Cited by 139 publications

(57 citation statements)

References 26 publications

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“…Another area in considerable expansion is extraction of secondary metabolites from plants using hydrophobic (D)ESs through microextraction techniques. Cao et al . demonstrated the efficiency of hydrophobic (D)ESs as designer solvents in the extraction of polyprenyl acetates from ginkgo biloba leaves.…”

Section: Hydrophobic (Deep) Eutectic Solventsmentioning

confidence: 99%

“…The first hydrophobic (D)ES reported were based on quaternary ammonium salts with long alkyl chains and decanoic acid, where the hydrophobic characterw as confirmed by studying the leachingo f( D)ES components into the water phase and water uptake. [11a] Following the same idea, severals tudies on the use of quaternary ammonium salts with long alkyl chains were then performed, [11,[13][14][15][16] using HBDs with different chemical structures,s uch as carboxylic acids and alcohols with different alkyl chains (C 2 -C 18 )a nd with double bonds. Regarding the use of [N 4444 ]Cl and [N 4444 ]Br,h ydrophobic (D)ES could be prepared using these compounds and two phases were obtained when in contact with water.T heir chemical stability will be discussed below and conclusions drawn.…”

Section: Development and Preparation Of Hydrophobic (D)essmentioning

confidence: 99%

“…Another areai nc onsiderable expansion is extraction of secondary metabolites from plants using hydrophobic (D)ESs through microextractiontechniques. Cao et al [13] demonstrated the efficiency of hydrophobic (D)ESs as designer solvents in the extraction of polyprenyl acetates from ginkgo biloba leaves.T he authors proposed at ernary hydrophobic (D)ES composed of methyl trioctylammonium chloride,c apryl alcohol, and octylic acid at am olar ratio of 1:2:3a st he moste fficient extractant.T hey also studied the extraction of artemisinin from artemisia annua leaves. [14] Hydrophobic (D)ES based on methyltrioctylammonium chloride and1 -butanola tamolar ratio of 1:4s howed the highest extraction yield and also a higher efficiency than the conventionally used organic solvent, petroleum ether.T hese studies illustrate the versatility and the tunability of properties of the hydrophobic (D)ESs as green and safe extraction solvents for pharmaceutical applications.…”

Section: Applicationso Fh Ydrophobic (D)ess-from Nature To Green Chemmentioning

confidence: 99%

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Quest for Green‐Solvent Design: From Hydrophilic to Hydrophobic (Deep) Eutectic Solvents

2019

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Deep eutectic solvents (DESs) consist of a mixture of two or more solid components, which gives rise to a lower melting point compared to the starting materials. Until recently only hydrophilic DESs were available, and despite their revolutionary role in the alternative‐solvents field, important issues in chemistry, and chemical engineering (such as water‐related problems and the replacement of toxic volatile organic compounds) could not be tackled. Hydrophobic (deep)—here in parenthesis due to the different depths of the eutectic melting points—eutectic solvents are a subclass of DESs where both components are hydrophobic. The low toxicity, high biodegradability, and straightforward preparation without further purification steps of naturally occurring low‐cost compounds are among the key advantages. Although research on hydrophobic DESs is scarce (the first report was only published in 2015), some interesting features and applications have been reported and deserve to be evaluated and comparisons established. This Minireview is divided into two parts: The first part provides a brief general introduction to DESs and the second part discusses the nomenclature using solid–liquid phase diagram analysis, chemical stability, thermophysical properties comparison, and finally the most important emerging fields of application.

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Section: Hydrophobic (Deep) Eutectic Solventsmentioning

confidence: 99%

Section: Development and Preparation Of Hydrophobic (D)essmentioning

confidence: 99%

Section: Applicationso Fh Ydrophobic (D)ess-from Nature To Green Chemmentioning

confidence: 99%

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Quest for Green‐Solvent Design: From Hydrophilic to Hydrophobic (Deep) Eutectic Solvents

2019

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“…Additionally, the utilisation of the reported method, such as ultrasound‐assisted extraction (UAE), pressurised liquid extraction and heat reflux extraction normally required large amounts of energy, which would increase the energy consumption . In comparison, DESs have been used as solvents to extract prenyl‐containing compounds and flavonol glycosides, and show obvious advantages …”

Section: Introductionmentioning

confidence: 99%

“…[32][33][34] In comparison, DESs have been used as solvents to extract prenyl-containing compounds and flavonol glycosides, and show obvious advantages. 8,[35][36][37] In the present study, an efficient extraction method using DES was developed for the extraction of prenylflavonoid glucosides from E. pubescens without using organic solvents and expensive specialised instrumentation. A series of DESs were synthesised and screened for their extraction efficiency.…”

Section: Introductionmentioning

confidence: 99%

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

Wang

Peng

Zhao

et al. 2019

Phytochemical Analysis

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Introduction The Epimedium herb, Yinyanghuo in Chinese, is a famous Chinese herbal medicine. In this study, an efficient extraction method was developed for the extraction of major bioactive constituent epimedin A, epimedin B, epimedin C and icariin from E. pubescens Maxim. using deep eutectic solvents (DESs). Methodology A series of choline chloride‐based DESs were synthesised for the extraction of four target compounds. DES composed of lactic acid and choline chloride with the ratio of 2:1 was selected as the most promising. Three vital factors affecting the extraction yields including water content, volume of DES aqueous solution and extraction time were optimised systematically by Box–Behnken experimental design in combination with response surface methodology. A high‐performance liquid chromatography ultraviolet (HPLC‐UV) method was developed for the sensitive and accurate quantification. Results The optimal extraction conditions were obtained as follows: water content of 17.5% (v/v), volume of DES aqueous solution 3.14 ml, and extraction time of 21 min. Under the optimal extraction conditions, the developed DES method could supply almost the same extraction yield as 50% ethanol, which were 98%, 99%, 97%, 96% for epimedin A, epimedin B, epimedin C and icariin, respectively. Conclusion The present study exhibited high efficiency in extraction of prenylflavonol glycosides in E. pubescens Maxim. Thus, DESs could be used as an alternative for efficient extraction and quantification of biologically active components from natural medical plants.

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Extraction of Bioactive Compounds

Zainal-Abidin

Hayyan

Ngoh

et al. 2019

Deep Eutectic Solvents

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Tailor-made hydrophobic deep eutectic solvents for cleaner extraction of polyprenyl acetates from Ginkgo biloba leaves

Cited by 139 publications

References 26 publications

Quest for Green‐Solvent Design: From Hydrophilic to Hydrophobic (Deep) Eutectic Solvents

Quest for Green‐Solvent Design: From Hydrophilic to Hydrophobic (Deep) Eutectic Solvents

Efficient extraction and determination of prenylflavonol glycosides in Epimedium pubescens Maxim. using deep eutectic solvents

Extraction of Bioactive Compounds

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