Tailed nuclei and dicentric chromosomes in irradiated subjects

Kravtsov, Viacheslav; Fedortseva, R. F.; Starkova, Ye.V; Yartseva, N. M.; Nikiforov, A.M.

doi:10.1016/s0969-8043(00)00057-9

Cited by 15 publications

(19 citation statements)

References 4 publications

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“…Thus, with simultaneous exposure to gamma radiation and agrochemicals, the following anomalies were formed in somatic cells of fish: micronuclei, «tailed» nuclei, deformed nuclei and vacuolated nuclei. However, a com bination of «tailed» nuclei and nucleoplasmic bridges appeared only after exposure to ion izing radiation [7,8,16,25,41]. This was also confirmed by studies in which the appearance of «tailed» nuclei and nucleoplasmic bridges was observed in the thyroid cells of mammals, in various cell lines and in peripheral blood lymphocytes of liquidators of the Chernobyl disaster [15,30,41].…”

Section: Cytological Anomalies After Ionizing Radiation Exposurementioning

confidence: 56%

“…У разных видов рыб [7,34] и человека [25] на блюдались «хвостатые» ядра в клетках после воз действия радиации. Прослеживается строгая корреляция между частотой встречаемости межъ ядерных хроматиновых мостов и «хвостатых» ядер [5], что говорит о том, что последние формируются путем разрыва мостов в ходе цитокинеза.…”

Section: Cytological Anomalies After Ionizing Radiation Exposureunclassified

“…Socalled «tailed» nuclei were observed in cells of different fish species [7,34] and hu man [25] after exposure to radiation. There is a strong correlation between the frequency of occurrence of nucleoplasmic bridges and «tailed» nuclei [5], which indicates that the latter are formed by rupture of bridges during cytokinesis.…”

Section: Cytological Anomalies After Ionizing Radiation Exposurementioning

confidence: 99%

“…Так, при одновременном воздействии гаммаизлучения и агрохимикатов у рыб формировались следу ющие аномалии: микроядра, «хвостатые» ядра, деформированные ядра и ядра с вакуолями. Од нако комбинация «хвостатых» ядер и межъядер ных мостов появлялась только после воздействия ионизирующего излучения [7,8,16,25,41]. Под тверждением этому были также исследования, в которых появление «хвостатых» ядер и межъ ядерных хроматиновых мостов наблюдалось в ти реоцитах млекопитающих, различных клеточных линиях и лимфоцитах в периферической крови ликвидаторов аварии на Чернобыльской АЭС [15,30,41].…”

Section: Cytological Anomalies After Ionizing Radiation Exposureunclassified

See 3 more Smart Citations

Nuclear abnormalities of somatic cells as universal indicator of ionizing radiation exposure

Anbuman¹,

Livanova²,

Fedortseva³

2017

Med.-biol. soc.-psihol. probl. bezop. črezvyčajnyh situac.

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Section: Cytological Anomalies After Ionizing Radiation Exposurementioning

confidence: 56%

Section: Cytological Anomalies After Ionizing Radiation Exposureunclassified

Section: Cytological Anomalies After Ionizing Radiation Exposurementioning

confidence: 99%

Section: Cytological Anomalies After Ionizing Radiation Exposureunclassified

See 2 more Smart Citations

Nuclear abnormalities of somatic cells as universal indicator of ionizing radiation exposure

Anbuman¹,

Livanova²,

Fedortseva³

2017

Med.-biol. soc.-psihol. probl. bezop. črezvyčajnyh situac.

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“…The length of these tails varies in lymphocytes of peripheral blood from 2 to 7 μm. Color, chromatin structure and intensity of "tails" staining usually correspond to the colors of the nucleus [33]. It should be noted that sometimes the "tail" chromatin is more compacted at the periphery of terminal expansion than the chromatin of the nucleus, while the terminal expansion has a clear center.…”

Section: Nucleoplasmatic Bridgesmentioning

confidence: 92%

Nuclear Abnormalities of Lymphocytes as the Simplest Markers for Bioindication Test in Case of Mass Casualty Events Involving Radiation Exposure

Kravtsov¹,

Livanova²,

Starkova³

2017

Emerg Med

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Radiation exposure leads to a large number of victims who seek medical help in the first hours. To provide medical care, it is necessary to correctly establish the fact and dose of radiation by bioindication and biodosimetry methods. Lymphocytes containing nuclear anomalies are easily detected cells of peripheral blood and are suitable as objects of bioindication in the case of radioactive exposure to a large number of people. Among these anomalies we distinguish micronuclei, "tailed" nuclei, nucleoplasmatic bridges, dumbbell-shaped nuclei, etc. This review observes the main types of these nuclear anomalies of lymphocytes in the light of their common origin from dicentric chromosomes. We recommend using these alterations in peripheral blood lymphocytes nuclei as the simplest biomarkers in the framework of bioindication tests when it is necessary to work with a large number of victims.

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Karyopathological traits of thyrocytes and exposure to radioiodines in Belarusian children and adolescents following the accident at the Chernobyl nuclear power plant

Надыров

Рожко

Kravtsov

et al. 2012

Radiat Environ Biophys

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The Belarus-American (BelAm) Thyroid Study cohort consists of persons 0–18 years of age at the time of exposure to radioiodines from the 1986 Chernobyl nuclear power plant accident who have undergone serial thyroid screenings with referral for fine-needle aspiration biopsy (FNAB) using standardized criteria. We investigated thyrocyte nuclear abnormalities in cytological samples from FNABs in 50 BelAm subjects with thyroid nodules and 43 control patients from Leningrad, Russia, unexposed to Chernobyl fallout. Nuclear abnormalities such as internuclear chromosome bridges and derivative nuclei with broken bridges (i.e., “tailed” nuclei), formed from dicentric and ring chromosomes, may be cellular markers of radiation exposure. In the exposed BelAm cohort, thyrocytes with bridges were present in 80% of subjects with single-nodular goiters compared with 27% of unexposed controls. The average frequency of thyrocytes with bridges was also significantly higher in the BelAm subjects than in controls as was the mean frequency of thyrocytes with tailed nuclei. In the case of multi-nodular goiters, thyrocytes with bridges were present in 75.0% of exposed BelAm patients compared with 16.7% of unexposed controls. Thyrocytes with tailed nuclei were observed in all of the BelAm subjects but in only 35% of controls, and the mean frequency of tailed nuclei was significantly higher. Unusually long bridges were detected in 29% of BelAm patients with single-nodular goiters and 35% of cases with multi-nodular goiters, while no such abnormalities were observed in the follicular thyroid epithelium of patients from the Leningrad region. Further study is needed to understand whether these phenomena represent irradiation consequences in the human organism.

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Tailed nuclei and dicentric chromosomes in irradiated subjects

Cited by 15 publications

References 4 publications

Nuclear abnormalities of somatic cells as universal indicator of ionizing radiation exposure

Nuclear abnormalities of somatic cells as universal indicator of ionizing radiation exposure

Nuclear Abnormalities of Lymphocytes as the Simplest Markers for Bioindication Test in Case of Mass Casualty Events Involving Radiation Exposure

Karyopathological traits of thyrocytes and exposure to radioiodines in Belarusian children and adolescents following the accident at the Chernobyl nuclear power plant

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