Tail Length Determination in Bacteriophage T4

Abuladze, Natalia; Gingery, Mari; Tsai, Jerry; Eiserling, Frederick A.

doi:10.1006/viro.1994.1128

Cited by 91 publications

(60 citation statements)

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“…One possibility is that one or more molecules of the toxin proteins (Afp17/18) was packaged in the tube. A second possibility is that some of the density is for a ruler protein that determines the length of the Afp particle as has been described in bacteriophages (33,34). The TBC particles have variable length tubes, indicating that any lengthdetermining factor is absent.…”

Section: The Relationship Of Putative Sheath Proteins Of Afp With Thomentioning

confidence: 99%

Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage of Serratia entomophila

Heymann

Bartho

Rybakova

et al. 2013

Journal of Biological Chemistry

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Background: Antifeeding prophage (Afp) is a toxin-delivery bacteriophage tail-like particle. Results: The syringe-like three-dimensional structure, composed of a helical sheath formed by 10 disks, a baseplate, and a central tube displays 6-fold symmetry. Conclusion: Although similar to other type VI secretion systems, Afp possesses unique features. Significance: This is the first insight into the three-dimensional structure of a tailocin.

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Section: The Relationship Of Putative Sheath Proteins Of Afp With Thomentioning

confidence: 99%

Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage of Serratia entomophila

Heymann

Bartho

Rybakova

et al. 2013

Journal of Biological Chemistry

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“…ORF 27 shares a domain with the Staphylococcus phage-dominated minor structural protein Gp20 family (PF06810), not to be confused with the synonymous T4-like capsid assembly protein Gp20 (PF07230), a common cyanophage marker gene (Zhong et al, 2002). Among the 'tail formation' genes, ORF 43, encoding a phage tail length tape measure protein, is involved in the regulation of the phage tail length (Abuladze et al, 1994). In the 'tail fibre, host recognition' module, ORF 45 contains a domain of the Phage tail fibre adhesin Gp38 Pfam family (Table 1).…”

Section: Genome Features and Annotationsmentioning

confidence: 99%

Ecogenomics and genome landscapes of marine Pseudoalteromonas phage H105/1

et al. 2010

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Marine phages have an astounding global abundance and ecological impact. However, little knowledge is derived from phage genomes, as most of the open reading frames in their small genomes are unknown, novel proteins. To infer potential functional and ecological relevance of sequenced marine Pseudoalteromonas phage H105/1, two strategies were used. First, similarity searches were extended to include six viral and bacterial metagenomes paired with their respective environmental contextual data. This approach revealed 'ecogenomic' patterns of Pseudoalteromonas phage H105/1, such as its estuarine origin. Second, intrinsic genome signatures (phylogenetic, codon adaptation and tetranucleotide (tetra) frequencies) were evaluated on a resolved intragenomic level to shed light on the evolution of phage functional modules. On the basis of differential codon adaptation of Phage H105/1 proteins to the sequenced Pseudoalteromonas spp., regions of the phage genome with the most 'host'-adapted proteins also have the strongest bacterial tetra signature, whereas the least 'host'-adapted proteins have the strongest phage tetra signature. Such a pattern may reflect the evolutionary history of the respective phage proteins and functional modules. Finally, analysis of the structural proteome identified seven proteins that make up the mature virion, four of which were previously unknown. This integrated approach combines both novel and classical strategies and serves as a model to elucidate ecological inferences and evolutionary relationships from phage genomes that typically abound with unknown gene content.

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“…The tail tip complex attaches the tape measure, or ruler, protein, which determines the length of the tail tube. 127,134,135 The tape measure protein is extended through the central channel of the tail tube as it is being built. The polymerizing tail tube protein molecules form a stack of hexameric rings on top of the tail tip complex, 136 which encircle the tape measure protein.…”

Section: Structure Of the Phage Tailsmentioning

confidence: 99%