Tail and eye movements evoked by electrical microstimulation of the optic tectum in goldfish

Herrero, L.; Rodrı́guez, Fernando; Salas, Cosme; Torres, Blas

doi:10.1007/s002210050403

Cited by 95 publications

(105 citation statements)

References 59 publications

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“…The control ablated group captured significantly more paramecia than the bilateral MeLc and MeLr group across the 5 h assay period and was indistinguishable from the unablated group in C. confirms previous electrophysiological and lesioning studies in other vertebrates (Ewert et al, 2001;Lomber et al, 2001;Doubell et al, 2003). For instance, in trout, activation of the tectum elicits orienting movements, the direction and amplitude of which depend on the site of stimulation (Herrero et al, 1998b). However, our study also showed that the tectum is not always necessary for prey consumption, because paramecia numbers still drop at measurable rates in the presence of tectum-ablated (or blind) fish (Fig.…”

Section: Discussionsupporting

confidence: 86%

Visual Prey Capture in Larval Zebrafish Is Controlled by Identified Reticulospinal Neurons Downstream of the Tectum

Gahtan¹,

Tanger²,

Baier³

2005

J. Neurosci.

303

335

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Many vertebrates are efficient hunters and recognize their prey by innate neural mechanisms. During prey capture, the internal representation of the prey's location must be constantly updated and made available to premotor neurons that convey the information to spinal motor circuits. We studied the neural substrate of this specialized visuomotor system using high-speed video recordings of larval zebrafish and laser ablations of candidate brain structures. Seven-day-old zebrafish oriented toward, chased, and consumed paramecia with high accuracy. Lesions of the retinotectal neuropil primarily abolished orienting movements toward the prey. Wild-type fish tested in darkness, as well as blind mutants, were impaired similarly to tectum-ablated animals, suggesting that prey capture is mainly visually mediated. To trace the pathway further, we examined the role of two pairs of identified reticulospinal neurons, MeLc and MeLr, located in the nucleus of the medial longitudinal fasciculus of the tegmentum. These two neurons extend dendrites into the ipsilateral tectum and project axons into the spinal cord. Ablating MeLc and MeLr bilaterally impaired prey capture but spared several other behaviors. Ablating different sets of reticulospinal neurons did not impair prey capture, suggesting a selective function of MeLr and MeLc in this behavior. Ablating MeLc and MeLr neurons unilaterally in conjunction with the contralateral tectum also mostly abolished prey capture, but ablating them together with the ipsilateral tectum had a much smaller effect. These results suggest that MeLc and MeLr function in series with the tectum, as part of a circuit that coordinates prey capture movements.

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Section: Discussionsupporting

confidence: 86%

Visual Prey Capture in Larval Zebrafish Is Controlled by Identified Reticulospinal Neurons Downstream of the Tectum

Gahtan¹,

Tanger²,

Baier³

2005

J. Neurosci.

303

335

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“…Pretectal nuclei, as well as the optic tectum, have been implicated in the regulation of visual and motor behaviour, multimodal sensory integration [32] and escape responses [33], which may explain the significant increased in subordinates or loser conditions, as observed in the present study. In mammals, avoidance responses are obtained from stimulations in a region of the superior colliculus that appears to represent the upper visual field [34].…”

Section: Discussionsupporting

confidence: 64%

Social modulation of brain monoamine levels in zebrafish

Teles

Dahlbom

Winberg

et al. 2013

Behavioural Brain Research

106

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h i g h l i g h t s• Zebrafish were exposed to different fighting experiences: winning, losing and mirror-fighting.• Winners show higher serotonergic and dopaminergic activity in the telencephalon.• Losers show higher serotonergic in the optic tectum.• No significant changes in monoamine activity were observed in mirror fighters.• Monoamines are differentially regulated by social interactions in different brain regions. a r t i c l e i n f o t r a c tIn social species animals tend to adjust their social behaviour according to the available social information in the group, in order to optimize and improve their one social status. This changing environment requires for rapid and transient behavioural changes that relies primarily on biochemical switching of existing neural networks. Monoamines and neuropeptides are the two major candidates to mediate these changes in brain states underlying socially behavioural flexibility. In the current study we used zebrafish (Danio rerio) males to study the effects of acute social interactions on rapid regional changes in brain levels of monoamines (serotonin and dopamine). A behavioural paradigm under which male zebrafish consistently express fighting behaviour was used to investigate the effects of different social experiences: winning the interaction, losing the interaction, or fighting an unsolved interaction (mirror image). We found that serotonergic activity is significantly higher in the telencephalon of winners and in the optic tectum of losers, and no significant changes were observed in mirror fighters suggesting that serotonergic activity is differentially regulated in different brain regions by social interactions. Dopaminergic activity it was also significantly higher in the telencephalon of winners which may be representative of social reward. Together our data suggests that acute social interactions elicit rapid and differential changes in serotonergic and dopaminergic activity across different brain regions.

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“…Interestingly, this nucleus projects to the optic tectum. It is known that the optic tectum is involved in the visual perception of objects and has a role in visually mediated escape responses (Springer et al, 1977;Herrero et al, 1998). Although chemosensory stimuli could modulate visual functions at the level of the optic tectum, we can exclude this explanation for our findings, because destruction of the retinal DA-IPCs and intraocular application of the D2 antagonist sulpiride eliminate the effect of amino acids on visual function.…”

Section: Olfactory Input Modulates Zebrafish Visual Sensitivitymentioning

confidence: 73%

Olfactory input increases visual sensitivity in zebrafish: a possible function for the terminal nerve and dopaminergic interplexiform cells

Maaswinkel

2003

Journal of Experimental Biology

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SUMMARY Centrifugal innervation of the neural retina has been documented in many species. In zebrafish Danio rerio, the only so-far described centrifugal pathway originates from terminal nerve (TN) cell bodies that are located in the olfactory bulb. Most of the TN axons terminate in the forebrain and midbrain, but some project via the optic nerve to the neural retina, where they synapse onto dopaminergic interplexiform cells (DA-IPCs). While the anatomical pathway between the olfactory and visual organs has been described, it is unknown if and how olfactory signals influence visual system functions. We demonstrate here that olfactory input is involved in the modulation of visual sensitivity in zebrafish. As determined by a behavioral assay and by electroretinographic (ERG) recording, zebrafish visual sensitivity was increased upon presentation of amino acids as olfactory stimuli. This effect, however, was observed only in the early morning hours when zebrafish are least sensitive to light. The effect of olfactory input on vision was eliminated after lesion of the olfactory bulbs or after the destruction of DA-IPCs. Intraocular injections of a dopamine D2 but not a D1 receptor antagonist blocked the effect of olfactory input on visual sensitivity. Although we cannot exclude the involvement of other anatomical pathways, our data suggest that the TN and DA-IPCs are the prime candidates for olfactory modulation of visual sensitivity.

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Tail and eye movements evoked by electrical microstimulation of the optic tectum in goldfish

Cited by 95 publications

References 59 publications

Visual Prey Capture in Larval Zebrafish Is Controlled by Identified Reticulospinal Neurons Downstream of the Tectum

Visual Prey Capture in Larval Zebrafish Is Controlled by Identified Reticulospinal Neurons Downstream of the Tectum

Social modulation of brain monoamine levels in zebrafish

Olfactory input increases visual sensitivity in zebrafish: a possible function for the terminal nerve and dopaminergic interplexiform cells

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