Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis

Zhang, Yili; Chai, Yan; Pan, Xunzhang; Shen, H. F.; Wei, Xu; Xie, Yan-Ming

doi:10.2147/cia.s187588

Cited by 21 publications

(16 citation statements)

References 44 publications

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“…The present meta-analysis supports the beneficial effects of Tai Chi interventions on BMD at FN that were reported previously [106,107]. In contrast, Liu and Wang found no significant effect of Tai Chi on BMD [97].…”

Section: Discussionsupporting

confidence: 91%

Effect of different types of exercise on bone mineral density in postmenopausal women: A systematic review and meta-analysis

et al. 2020

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Postmenopausal women face a high risk of bone loss. Exercise has a beneficial effect to prevent bone deterioration in elderly women. This study was conducted to investigate the effect of different types of exercise on bone mineral density at the lumbar spine and femoral neck in postmenopausal women.This review followed the guidelines recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and was registered in advance in the International prospective register of systematic reviews (PROSPERO) (ID: CRD42018095097). Literature searches with no language restriction were conducted through PubMed, Scopus, Web of Science, Cochrane, Science Direct, Eric, ProQuest, and Primo up to March 1 2019 using related MeSH terms and key words. Controlled trials with ≥ 6 months intervention duration among postmenopausal women that comprised at least one exercise and one control group were included in this study. Meta-analyses were performed using random-effects models and effect sizes calculated using the standardised mean difference (SMD). Seven categories of exercise were classified and used in sub-group analyses. P-values < 0.05 were considered statistically significant.Seventy-five studies were included, assessing the bone mineral density of 5300 (range of mean age: 50–79) postmenopausal women who performed exercise or control protocols. Interventions ranged from six to 30 months and the most common exercise frequency was three sessions per week. The majority of studies employed multicomponent exercise interventions. Results of the meta-analyses showed a significant effect (SMD = 0.37, 95%-CI: 0.25–0.50) for lumbar spine and femoral neck (SMD = 0.33, 0.23–0.43) (all P < 0.0001).Sub-group analysis revealed large heterogeneity and no significant differences in exercise categories at the lumbar spine (P = 0.36) and femoral neck (P = 0.43). However, weight-bearing exercise + jumping + resistance training exhibited the largest effect (SMD = 0.71, 0.33–1.10) at the lumbar spine. Moreover, non-weight-bearing combined + resistance exercise revealed the largest effect (SMD = 0.68, 0.16–1.19) at the femoral neck. Contrary to our expectation, jumping alone indicated a greater decrease in bone mineral density compared to the control group at both the lumbar spine (−0.07, −0.46–0.32) and femoral neck (−0.12, −0.62–0.37).In conclusion, the current study provided a positive small effect of exercise on bone mineral density at the lumbar spine and femoral neck. Findings from sub-group analyses suggest larger benefits in multicomponent interventions that include weight-bearing and resistance training exercises compared to them as a single mode of exercise. Unequal numbers of studies were found for each category (e. g. jumping: two trials; dynamic resistance training: 15 trials), affecting the comparison between them. Therefore, findings should be interpreted with caution; they are not yet generalizable to specific types of exercise.

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Section: Discussionsupporting

confidence: 91%

Effect of different types of exercise on bone mineral density in postmenopausal women: A systematic review and meta-analysis

et al. 2020

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“…This poses a serious health concern worldwide [1] because osteoporotic fractures are the leading cause of disability and death in elderly patients [2] . The onset of this disease is associated with various factors, including aging, gender, insu cient calcium intake, vitamin D de ciency, low body mass index (BMI), decreased physical activity [3] , and hyperthyroidism [4] .…”

Section: Introductionmentioning

confidence: 99%

Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis

Zhao

Zhang

et al. 2021

J Bone Miner Metab

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Background: Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis.Methods: Using speci c keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle-Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. Revman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference and 95% con dence interval. The heterogeneity test was conducted according to I 2 and Q tests. Egger's test was used to quantitatively evaluate publication bias.Results: This analysis involved 12 studies and included 12,395 subjects. The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in the osteopenia were not signi cantly increased/decreased. There were no signi cant differences in LDL-C in postmenopausal women in osteopenia. TG was unchanged in the OP group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group but not in osteopenia group in all subjects Conclusions: HDL-C was elevated in patients with OP.

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“…It is accepted that serum calcium levels are within a normal range in patients with osteoporosis, but serum phosphatase and ALP can be somewhat changed in patients with osteoporosis [ 63 , 64 ]. ALP is a marker of bone turnover and vascular calcification in patients with chronic kidney disease [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study

Hao

Gao

et al. 2021

Med Sci Monit

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Background Accumulated evidence has suggested that hydrogen sulfide (H 2 S) has a role in bone formation and bone tissue regeneration. However, it is unknown whether the H 2 S content is associated with bone mineral density (BMD) in patients with osteopenia/osteoporosis. Material/Methods In the present study, we aimed to explore the changes of serum H 2 S in osteopenia and osteoporosis patients. We analyzed femur expression of cystathionine β synthase (CBS), cystathionine γ lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), which are key enzymes for generating H 2 S. Results Sixteen (16%) patients had osteopenia, 9 (9%) had osteoporosis, and 75 (75%) had normal BMD. In comparison with patients with normal BMD (controls), the serum levels of H 2 S were unexpectedly increased in patients with osteopenia and osteoporosis. This increase was much higher in patients with osteoporosis than in those with osteopenia. Serum H 2 S levels were negatively correlated with femoral BMD, but not lumbar BMD. Interestingly, the expression of CBS and CSE were downregulated in femur tissues in patients with osteoporosis, whereas the expression of 3-MST remained unchanged. Serum phosphorus levels, alkaline phosphatase, hemoglobin, and triglycerides were found to be closely associated with CBS and CSE scores in femur tissues. Conclusions Serum H 2 S levels and femur CBS and CSE expression may be involved in osteoporosis pathogenesis.

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Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis

Cited by 21 publications

References 44 publications

Effect of different types of exercise on bone mineral density in postmenopausal women: A systematic review and meta-analysis

Effect of different types of exercise on bone mineral density in postmenopausal women: A systematic review and meta-analysis

Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis

Association of Hydrogen Sulfide with Femoral Bone Mineral Density in Osteoporosis Patients: A Preliminary Study

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