Tai Chi Ameliorates Coronary Heart Disease by Affecting Serum Levels of miR-24 and miR-155

Abstract

The protective role of Tai Chi in coronary heart disease (CHD) has been widely reported. However, the exact molecular mechanism remains unclear. Serum levels of miR-24 and miR-155 have been found to potentially be involved with CHD risk. Thus, the effects of Tai Chi on CHD risk were explored by measuring serum levels of miR-24 and miR-155. A total of 326 CHD patients were evenly divided into the Tai Chi (TG) and control (CG) groups. The activities of daily living ability (ADL) and exercise of self-care agency (ESCA) scores were compared between the two groups. Left ventricular ejection fraction (LVEF), SF-36 life quality, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to evaluate subjects’ cardiac function, quality of life, anxiety, and depression. Serum levels of miR-24 and miR-155 were measured by a real-time quantitative polymerase chain reaction (RT-qPCR). After a 6-month Tai Chi intervention, the ESCA, ADL, LVEF, and SF-36 scores in the TG group were higher than those in the CG group ( p < 0.05). The time of arrhythmia and atrioventricular block recovery and hospital stay, and the scores of SAS and SDS in the TG group were lower than in the CG group ( p < 0.05). Serum levels of miR-24 and miR-155 in the TG group were also lower than in the CG group ( p < 0.05). In addition, serum levels of miR-24 and miR-155 were negatively associated with the ESCA, ADL, LVEF and SF-36 scores, and had adverse effects on life quality. Altogether, these present findings demonstrate that Tai Chi improves CHD prognosis, by affecting serum levels of the miR-24 and miR-155.

Tai Chi exercise for psychological well-being among adults with cardiovascular disease: A systematic review and meta-analysis

“…A total of 15 clinical trials (13 RCTs, [25][26][27][28][29][30][31][32][33][34][35][36][37] two quasiexperimental studies with comparison groups 38,39 ) met the inclusion criteria ( Table 1). The majority of these studies were conducted in Asia (53.3%, n=8) or North America (33.3%, n=5), with the other studies conducted in Europe (13.3%, n=2).…”

“…The majority of these studies were conducted in Asia (53.3%, n=8) or North America (33.3%, n=5), with the other studies conducted in Europe (13.3%, n=2). There were a total of 1853 participants enrolled, including two studies among coronary heart disease participants (n=164, mean age=65 years, 37% women), 25,38 five studies among chronic heart failure participants (n=530, mean age=68 years, 34% women), [26][27][28][29]39 four studies among participants with hypertension (n=930, mean age=62 years, 55% women), 30,31,32,33 and four studies among stroke survivors (n=229, mean age=67 years, 51% women). [34][35][36][37] Tai Chi intervention…”

Targets identified from exercised heart: killing multiple birds with one stone

“…Of note, exercise-induced cardioprotective role of circulating microRNAs is not only through improving the endothelial function, but also in directly attenuating the progression of heart diseases. Specific exercise interventions such as Chinese Tai Chi can improve the life quality and block the progression of coronary heart disease (CHD) via inhibiting miR-24 and miR-155, whose level is lower in the serum of Tai Chi exercised CHD patients than that of sedentary ones 123 .…”

Sustained impact of subcutaneous immunotherapy among patients with allergic rhinitis who experienced treatment delay due to the COVID-19 pandemic: A multicenter, two-arm, real-world study

“…To investigate the level of anxiety and depression related symptoms in patients undergoing SCIT at V0 and V1, we compared the SAS and SDS data to healthy controls: healthy subjects outside of 22 or during 23 the COVID-19 outbreak; COVID-19 related individuals (front-line clinical staff 24 or survivors 25 of COVID-19); patients with allergy and inflammation related diseases (AR 26 , asthma 27 , chronic rhinosinusitis (CRS) 28 ); patients with chronic disorders (coronary heart disease (CHD) 29 , functional dyspepsia (FD) 22 and primary insomnia (PI) 30 ); and cancer patients post radiotherapy (RT) 31 in China.…”