Taguchi’s Approach to Quality Improvement

Vuchkov, Ivan N.; Boyadjieva, Lidia N.

doi:10.1007/978-94-009-0009-7_4

Cited by 4 publications

(4 citation statements)

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“…By using face-centered star points, the central composite design can also be constrained to the same three low, medium, and high levels. 35 -38 The three independent input variables were blowing agent content ( ba , %), talc content ( ta , %), and injection velocity ( v w , cm 3 /s). The values of independent variables used in the plan (the content of the blowing agent and injection conditions) were determined on the basis of preliminary investigations in such a way that the obtained parts were of good quality, that is, they correctly represented the shape of the cavity, did not have burn marks, sink marks, and so on.…”

Section: Methodsmentioning

confidence: 99%

The influence of blowing agent addition, talc filler content, and injection velocity on selected properties, surface state, and structure of polypropylene injection molded parts

2019

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The effects of blowing agent, talc, and injection velocity on properties of polypropylene molded parts were presented. Blowing agent was dosed to plastic in amounts 1–2% and talc 10–20%. The results of selected properties, such as weight, thickness, hardness, impact strength, tensile strength, and gloss, were presented. The article also presents microscopic investigations. The blowing agent and talc content have a large impact on mechanical properties and gloss of parts than addition of blowing agent. The use of the blowing agent in an amount of 2 wt% will allow the reduce injection cycle time by reducing the hold pressure and hold time. Addition of blowing agents lowers of tensile strength, hardness, impact strength, and significantly affected the gloss. Talc filler contributes to a significant increase in the weight of parts, a decrease in hardness, impact strength, and tensile strength. The injection velocity has no significant effect on parts properties.

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Section: Methodsmentioning

confidence: 99%

The influence of blowing agent addition, talc filler content, and injection velocity on selected properties, surface state, and structure of polypropylene injection molded parts

2019

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“…A contour plot is the projection of the response surface as a two-dimensional plane . The values for two variables ( x - and y - factors) are represented on the x - and y -axes (predictors), while the values for the z -factor (response) are represented by lines, called contours.…”

Section: Methodsmentioning

confidence: 99%

Parametric Optimization of Selenite and Selenate Biosorption Using Wheat Bran in Batch and Continuous Mode

Ranjan

Hasan

2010

J. Chem. Eng. Data

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The present work has successfully optimized the biosorption of selenite and selenate species using wheat bran in both batch and continuous column mode with the help of central composite design (CCD). In batch mode the parameters which were taken into account were pH, biomass dose, initial selenium concentration, and temperature, whereas in continuous mode bed height, flow rate, and initial selenium concentration were studied. A second-order polynomial regression model was used, and results showed high regression coefficients (R 2, that is, 97.65 % for both Se(IV) and Se(VI) in batch mode and 97.95 % and 97.61 % for Se(IV) and Se(VI), respectively, in continuous mode), indicating good agreement with experimental data. Low values of standard deviations were also obtained, showing the adequacy of the proposed regression models in both batch and continuous mode. Contour plots predicted the maximum uptake of Se(IV) (49.56 μg·g−1) and Se(VI) (41.37 μg·g−1) at pH 2, initial selenium concentration of 1000 μg·L−1, temperature of 20 °C, and biomass dose of 20 g·L−1 in batch mode, whereas it was (73.05 and 58.29) μg·g−1 for Se(IV) and Se(VI) at a bed height of 25 cm, flow rate of 1.66 mL·min−1, and initial selenium concentration of 1000 μg·L−1 in continuous mode.

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“…The general quality control theory for industrial products, established by Shewhart et al, has contributed widely to the improved quality of industrial products and deepened understanding of the manufacturing process. , In recent years, there has been renewed interest in the concept of quality by design (QbD), which is a term coined to denote quality in processes in the pharmaceutical field. − In the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines, QbD is defined as a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control based on sound science and quality risk management to ensure product quality. Statistical approaches, such as design of experiment (DoE) and regression analysis, are extremely effective and powerful tools for the development of APIs based on the concept of QbD. − In DoE, selecting the method of experimental design is important. Depending on the experimental design, some effects might not be able to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

Application of a Statistical Approach to Process Development of Futibatinib by Employing Quality-by-Design Principles. Part 1: Identification of Critical Process Parameters for Impurities

Abe

Emori

2022

Org. Process Res. Dev.

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We focus on a novel experimental design and statistical analysis to identify the critical process parameters (CPPs) of impurities in futibatinib, which is a fibroblast growth factor receptor inhibitor. First, using failure mode and effects analysis, we identify 11 potential CPPs as the process parameters to be investigated. Next, an L 12 orthogonal experiment of the Plackett–Burman type is designed for risk analysis to check whether the 11 potential CPPs are in fact CPPs. Finally, for each impurity, analysis of variance, regression analysis, and regression diagnosis are carried out, enabling the CPPs to be analyzed correctly. Based on the quality-by-design concept, we identify three impurities that impact the impurity profile of the active pharmaceutical ingredient and five CPPs of the impurities, focusing on design of experiment and statistical analysis. We also clarify the process parameters to be examined in more detail for commercial production.

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Taguchi’s Approach to Quality Improvement

Cited by 4 publications

References 0 publications

The influence of blowing agent addition, talc filler content, and injection velocity on selected properties, surface state, and structure of polypropylene injection molded parts

The influence of blowing agent addition, talc filler content, and injection velocity on selected properties, surface state, and structure of polypropylene injection molded parts

Parametric Optimization of Selenite and Selenate Biosorption Using Wheat Bran in Batch and Continuous Mode

Application of a Statistical Approach to Process Development of Futibatinib by Employing Quality-by-Design Principles. Part 1: Identification of Critical Process Parameters for Impurities

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