Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats

Zanovello, Mariana; Mariano, Luísa Nathália Bolda; Cechinel-Zanchett, Camile Cecconi; Boeing, Thaise; Tazinaffo, Gustavo Cembranelli; Silva, Luísa Mota da; Silva, Denise Brentan; Gasparotto, Arquimedes; Souza, Priscila de

doi:10.1016/j.jep.2021.114393

Cited by 17 publications

(12 citation statements)

References 41 publications

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“…Electrolytes concentrations (Na + , K + , Cl - and Ca 2+ ), pH, and conductivity were determined in each urine sample at the end of the experiment. For details of analytical procedures, see Boeing et al and Zanovello et al 15 16 .…”

Section: Methodsmentioning

confidence: 99%

Diuretic, Natriuretic, And Ca2+-Sparing Effect Of The Alkaloid Boldine In Rats

Steimbach,

da Silva,

Mariano

et al. 2023

Drug Res (Stuttg)

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Background Previous studies indicate the renal vasodilating effects of boldine, an alkaloid found in Peumus boldus. However, its potential to induce diuresis still needs to be studied. Methods Wistar rats were used and the urine volume was noted for 8 h and further studied. Results The acute treatment at 0.1 and 0.3 mg/kg of boldine showed a diuretic, natriuretic, and Ca2+-sparing effect in rats without changing the urinary elimination of K+and Cl-. When boldine was given in combination with hydrochlorothiazide, there was an increase in urinary volume compared to the vehicle group. However, this was not different from the treatments in its isolated form. Urine Ca2+values remained low but were not enhanced by this association. The excretion of Na+and Cl- was significantly increased compared to the group that received only vehicle or boldine. On the other hand, although the association of amiloride plus boldine did not result in a diuretic effect, the increase in Na+and the reduction in K+excretion were significantly potentiated. Furthermore, in the presence of the non-selective muscarinic receptor antagonist atropine, boldine showed reduced capacity to increase urinary volume, maintaining the natriuretic and Ca2+-sparing effect, besides a very evident K+-sparing action. Similar results were obtained in the presence of the non-selective cyclooxygenase inhibitor indomethacin. Furthermore, boldine showed an ex vivo antiurolithiasis activity, reducing calcium oxalate’s precipitation and crystallization. Conclusions This study reveals the diuretic, natriuretic, Ca2+-sparing, and antiurolithiatic effects of boldine, an action possibly related to muscarinic receptor activation and prostanoid generation.

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Section: Methodsmentioning

confidence: 99%

Diuretic, Natriuretic, And Ca2+-Sparing Effect Of The Alkaloid Boldine In Rats

Steimbach,

da Silva,

Mariano

et al. 2023

Drug Res (Stuttg)

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“…The pH values, conductivity, and electrolytes excretion (Na + , K + ), were measured in each urine sample at the end of the experiment. For details on the analytical procedures, see the reference list [ 28 , 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

Diuretic and Natriuretic Effects of Hesperidin, a Flavanone Glycoside, in Female and Male Hypertensive Rats

Souza

Silva

Mariano

et al. 2022

Plants

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Hesperidin (HSP) is a major flavanone glycoside in citrus fruits, including sweet oranges and lemons. It demonstrates numerous pharmacological activities, such as antihypertensive effects and cardiac and kidney tissue protection. However, its effect on modulating renal function has yet to be properly explored. Female and male Wistar spontaneously hypertensive rats (SHR) were used to test the effect of HSP on renal function. The rats were divided into different groups, treated orally, and placed in metabolic cages for urine collection for 8 h. HSP, at doses of 0.3–3 mg/kg, led to an increase in urine volume in both female and male SHR. This effect was associated with increased Na+ elimination (3 mg/kg) without causing any change in K+ excretion or pH and conductivity values. When given HSP in combination with hydrochlorothiazide (HCTZ) or amiloride (AMLR), urine volume and Na+ elimination were significantly increased compared to the group that received only HSP. In relation to K+ excretion, the depleting effect of HCTZ and the sparing of AMLR prevailed in both groups. Pre-treatment with a non-selective cholinergic receptor antagonist, atropine, partially prevented HSP-induced diuresis and natriuresis in male SHR, but this effect was not demonstrated with the non-selective inhibitor of the enzyme cyclooxygenase, indomethacin. This study shows the diuretic action of HSP in hypertensive rats, an activity probably associated with the cholinergic pathway. Although various biological actions have already been defined for HSP, this pioneering research reveals its potential as a diuretic medicine.

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“…Furthermore, polyphenolic compounds in marigold flowers contain laricitrin and glycosides, these compounds are helpful and potentially antibacterial (Mandias et al, 2022;Verma et al, 2020). Flavonoid compounds and tannins work by damaging the cytoplasmic membrane and forming complexes with proteins through hydrophobic interactions, which ultimately disrupt the metabolism of bacterial cells resulting in lysis (Burlec et al, 2022;Zanovello et al, 2021;Zhang et al, 2020). Furthermore, previous research revealed that parts of the marigold flower have pharmacological benefits (Fu et al, 2019;Romes et al, 2021) and potential cosmetic raw materials (Kumar et al, 2021;Mekjaruskul et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Marigold Flower (Tagetes Erecta L.) Ethanol Extract Cream Against Staphylococcus Aureus

Cahyaningrum

Widyantari

2023

J Vocat Heal Stud

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Background: Acne is caused by inflammation and obstruction of the skin pores, which traps excess oil (acne vulgaris). The bacterium Staphylococcus aureus is the causative agent of acne. Treatment and prevention efforts can be made traditionally. Purpose: Testing the antibacterial efficacy of the marigold flower ethanol extract cream (Tagetes erecta L.) against Staphylococcus aureus. Method: This type of research is descriptive exploratory and experimental. Samples of ethanol extract from marigold flowers (Tagetes erecta L.) were formulated into three treatments, namely concentrations of 25%, 50%, and 100% with three replications. Antibacterial efficacy testing was carried out by the agar well diffusion method. Data analysis used One-way ANOVA and Tukey HSD tests. Result: The inhibition zones produced by the ethanolic extract of marigold flowers were 8.59 ± 0.047, 9.23 ± 0.026, and 10.23 ± 0.044 respectively. Thus, a higher concentration of the ethanolic extract of marigold flowers in the cream produced more significant inhibitory activity. Conclusion: The ethanol extract cream of marigold flower (Tagetes erecta L.) showed antibacterial activity against Staphylococcus aureus and is suitable to be applied as a cream for the traditional treatment of acne (acne vulgaris).

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Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats

Cited by 17 publications

References 41 publications

Diuretic, Natriuretic, And Ca2+-Sparing Effect Of The Alkaloid Boldine In Rats

Diuretic, Natriuretic, And Ca2+-Sparing Effect Of The Alkaloid Boldine In Rats

Diuretic and Natriuretic Effects of Hesperidin, a Flavanone Glycoside, in Female and Male Hypertensive Rats

Antibacterial Activity of Marigold Flower (Tagetes Erecta L.) Ethanol Extract Cream Against Staphylococcus Aureus

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