Tagesstationäre Endoprothetik – Ultra-Fast-Track

Grifka, Joachim; Greimel, Felix; Maderbacher, Günther

doi:10.1007/s00132-022-04242-9

Cited by 1 publication

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“…Тем не менее исследований, напрямую сравнивающих клиническую эффективность различных НПВП после ТЭКС, как в зарубежной, так и отечественной научной литературе встречается мало [6,7]. Следует отметить и то, что в РФ для пос леоперационного обезболивания традиционно применяются парентеральные формы НПВП, хотя за рубежом, в силу трансформации в последние два десятилетия артропластики крупных суставов в «хирургию одного дня», предпочтение отдается пероральным формам [8].…”

Section: Introductionunclassified

Efficacy of Novel Oral Non-Steroid Anti-Inflammatory Drugs for Pain Management After Total Knee Arthroplasty

Сараев¹,

Корнилов²

2023

Traumatology and Orthopedics of Russia

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Objective: To evaluate the efficacy and safety of Ketorol Express 10 mg in the form of a dispersible tablet in comparison with the tablet form of Ketonal 100 mg for anesthesia after TNA.Materials and methods: 100 patients (80 women, 20 men), randomized into the main (49) and control (51) groups, received Ketorol Express 10 mg (4 times a day) and Ketonal 100 mg (2 times a day) orally for postoperative anesthesia, respectively. Assessment by digital rating (NRS) and visual analog scales (VAS), pain diary, Comorbidity questionnaire, Oxford Knee Score12 scale, questionnaire of undesirable and side effects. The tolerability, ease of use and satisfaction with treatment are analyzed. The characteristics of the groups had no statistical differences.Results: the dynamics of pain on the NRS and VAS scales in both groups showed the same trend: the average values reached the level of moderate pain on the first day, decreasing by half by the 4th. The average, minimum and maximum levels of pain during the day at rest, during movements, as well as the amount of moderate / severe pain during the day, did not significantly differ, as did the rate of onset of analgesic effect during the first hour after taking the drug. In both groups, there was a comparable number of patients who additionally required parenteral analgesics: on average, 3.57 injections in the main and 4.41 in the control. However, on the 3rd and 4th days among patients receiving Ketorol Express, the need for additional anesthesia was significantly lower: by about a third by the 3rd day and almost twice by the fourth. The frequency of adverse events was similar in both groups, but satisfaction with the treatment was twice as high in the main group.Conclusion: oral forms of ketorolac and ketoprofen demonstrate comparable effectiveness in relieving pain, are well tolerated, therefore they can be an alternative to their parenteral use in the early postoperative period.

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Section: Introductionunclassified

Efficacy of Novel Oral Non-Steroid Anti-Inflammatory Drugs for Pain Management After Total Knee Arthroplasty

Сараев¹,

Корнилов²

2023

Traumatology and Orthopedics of Russia

View full text Add to dashboard Cite

show abstract

Tagesstationäre Endoprothetik – Ultra-Fast-Track

Cited by 1 publication

References 9 publications

Efficacy of Novel Oral Non-Steroid Anti-Inflammatory Drugs for Pain Management After Total Knee Arthroplasty

Efficacy of Novel Oral Non-Steroid Anti-Inflammatory Drugs for Pain Management After Total Knee Arthroplasty

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