Tagatose and milk allergy

Taylor, Stephen L; Lambrecht, Debra M.; Hefle, S.L.

doi:10.1111/j.1398-9995.2005.00701.x

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Although lactose often contains residual milk allergens, tagatose is much less likely to contain any milk allergens, because several steps in the tagatose production process denature or remove residual proteins in the lactose starting material. Therefore, tagatose should be safe for milk‐allergic individuals [105]. Tagatose has, since being established as GRAS in 2001 [11], developed a history of uses in foods with no reported incident of allergic or any other toxic event.…”

Section: Side Effects Of Tagatosementioning

confidence: 99%

Tagatose, a new antidiabetic and obesity control drug

Lu¹,

Levin²,

Donner

2007

Diabetes Obesity Metabolism

157

110

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A potentially important new drug for treating type 2 diabetes, tagatose, is now in phase 3 clinical trial. The history, development, additional health benefits, mechanisms of action and the potential for the drug are presented in context with a review of the rapidly growing epidemic of type 2 diabetes and treatments for it. An epimer of fructose, the natural hexose tagatose was originally developed by Spherix Incorporated (formerly Biospherics Inc.) as a low-calorie sugar substitute. Only 20% of orally ingested tagatose is fully metabolized, principally in the liver, following a metabolic pathway identical to that of fructose. Following a decade of studies, tagatose became generally recognized as safe for use in foods and beverages under US FDA regulation. The simple sugar is commercially produced by isomerization of galactose, which is prepared from lactose. Early human studies suggested tagatose as a potential antidiabetic drug through its beneficial effects on postprandial hyperglycaemia and hyperinsulinaemia. A subsequent 14-month trial confirmed its potential for treating type 2 diabetes, and tagatose showed promise for inducing weight loss and raising high-density lipoprotein cholesterol, both important to the control of diabetes and constituting benefits independent of the disease. Furthermore, tagatose was shown to be an antioxidant and a prebiotic, both properties cited in the maintenance and promotion of health. No current therapies for type 2 diabetes provide these multiple health benefits. The predominant side effects of tagatose are gastrointestinal disturbances associated with excessive consumption, generally accommodated within 1- to 2-week period. The health and use potentials for tagatose (branded Naturlose((R)) for this use) are given with respect to current type 2 diabetes drugs and markets. Under an FDA-affirmed protocol, Spherix is currently conducting a phase 3 trial to evaluate a placebo-subtracted treatment effect based on a decrease in HbA(1c) levels. Side effects, contraindications and possibly beneficial new findings will be carefully monitored. It is hoped that early results of the trial may become available by mid-2008. If a subsequent NDA is successful, tagatose may fill a major health need.

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Section: Side Effects Of Tagatosementioning

confidence: 99%

Tagatose, a new antidiabetic and obesity control drug

Lu¹,

Levin²,

Donner

2007

Diabetes Obesity Metabolism

157

110

View full text Add to dashboard Cite

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“…Furthermore, gene clusters involved in the metabolism of tagatose and xylose were identified as ATCC 10987 specific. Tagatose, an isomer of galactose, is found in dairy products (Wilhelm and Hollenberg, 1984; Taylor et al ., 2005) and xylose is abundantly available as a derivative of plant biomass. Finally, B. cereus ATCC 10987 contains genes putatively encoding urease, and it has been suggested that the corresponding urea degrading activity could increase the fitness of B. cereus ATCC 10987 in acidic environments (Rasko et al ., 2004).…”

Section: Introductionmentioning

confidence: 99%

Metabolic capacity of Bacillus cereus strains ATCC 14579 and ATCC 10987 interlinked with comparative genomics

Mols

Been

Zwietering³

et al. 2007

Environmental Microbiology

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Bacillus cereus is an important food-borne pathogen and spoilage organism. In this study, numerous phenotypes and the genomes of B. cereus strains ATCC 14579 and ATCC 10987 were analysed to compare their metabolic capacity and stress resistance potential. The growth performance of the two strains was assessed for nearly 2000 phenotypes, including use of nutrient sources, performance in acid and basic environments, osmo-tolerance and antibiotic resistance. Several food-relevant phenotypic differences were found between ATCC 14579 and ATCC 10987, such as differences in utilization of carbohydrates, peptides, amino acids and ammonia. Subsequently, the genomes of both strains were analysed with INPARANOID to search for strain-specific open reading frames (ORFs). B. cereus ATCC 14579 and ATCC 10987 were found to harbour 983 and 1360 strain-specific ORFs respectively. The strain-specific phenotypic features were interlinked with corresponding genetic features and for several phenotypic differences a related strain-specific genetic feature could be identified. In conclusion, the combination of phenotypic data with strain-specific genomic differences has led to detailed insight into the performance of the two B. cereus strains, and may supply indicators for the performance of these bacteria in different environments and ecological niches.

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“…Naturlose™ is a unique product, ideally suited for use in oral care products (toothpaste and mouthwash) and cosmetics (flavoured lipstick), as a safe sweetener. 39,40 Tagatose has been found to have a number of reported health benefits including treatment for type 2 diabetes, as a anti-hyperglycemic agent, promotion of weight loss, glucose spike blunting; anti-anemic, and anti-hemopilia; and promoting fetal survival and development a , [41][42][43][44][45][46] Due to increasing commercial interest in tagatose, studies on AIs to identify the molecular determinants of AI activity at the atomic level are warranted. We have undertaken the X-ray crystallographic studies of AI's.…”

Section: Introductionmentioning

confidence: 99%