TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation

Suter, Tracey A.C.S.; Blagburn, Sara V.; Fisher, Sophie; Anderson-Keightly, Heather; D’Elia, Kristen P.; Jaworski, Alexander

doi:10.1016/j.celrep.2019.12.085

Cited by 17 publications

(9 citation statements)

References 77 publications

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“…Continuous synthesis of ALCAM in growth cones is notably required for the preferential growth of retinal axons on ALCAM substrates and maintained by local mRNA translation ( Thelen et al, 2012 ). In the mouse motor system, Cntn2 accumulates in the distal segment of motor axons extending in the periphery and controls their fasciculation ( Suter et al, 2020 ). Conversely in the peripheral system, SynCAM2 and SynCAM3 were found to regulate contacts between sensory afferents as they enter the dorsal root entry zone of the spinal cord ( Frei et al, 2014 ).…”

Section: Adhesive Functions Of Cams In Circuit Wiringmentioning

confidence: 99%

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

Moreland

Poulain

2022

Front. Neurosci.

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Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they establish precise connections with post-synaptic partners. Cell adhesion molecules (CAMs) represent a large group of structurally diverse proteins well known to mediate adhesion for neural circuit assembly. Through their adhesive properties, CAMs act as major regulators of axon navigation, fasciculation, and synapse formation. While the adhesive functions of CAMs have been known for decades, more recent studies have unraveled essential, non-adhesive functions as well. CAMs notably act as guidance cues and modulate guidance signaling pathways for axon pathfinding, initiate contact-mediated repulsion for spatial organization of axonal arbors, and refine neuronal projections during circuit maturation. In this review, we summarize the classical adhesive functions of CAMs in axonal development and further discuss the increasing number of other non-adhesive functions CAMs play in neural circuit assembly.

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Section: Adhesive Functions Of Cams In Circuit Wiringmentioning

confidence: 99%

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

Moreland

Poulain

2022

Front. Neurosci.

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“…Contactins have been implicated in numerous developmental processes that help wire neurons together, or mediate neuron‐muscle and neuron‐glia interactions 274 . For example, Contactins can promote axonal growth, 275 guide axons, 276 promote myelination, 277 or fasciculate axons and prevent mistargeting 278 . In collaboration with other IgSF proteins (the two DSCAMs and the two Sidekicks), neuron‐specific expression of Contactins promote neurite targeting and synaptic specificity in the chick retina 279 .…”

Section: Receptor‐ligand Families For Synapse Targeting and Formationmentioning

confidence: 99%

“… 274 For example, Contactins can promote axonal growth, 275 guide axons, 276 promote myelination, 277 or fasciculate axons and prevent mistargeting. 278 In collaboration with other IgSF proteins (the two DSCAMs and the two Sidekicks), neuron‐specific expression of Contactins promote neurite targeting and synaptic specificity in the chick retina. 279 Contactins can interact in trans homophilically.…”

Section: Receptor‐ligand Families For Synapse Targeting and Formationmentioning

confidence: 99%

Structure and evolution of neuronal wiring receptors and ligands

Cortés

Pak

Özkan

2022

Developmental Dynamics

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One of the fundamental properties of a neuronal circuit is the map of its connections. The cellular and developmental processes that allow for the growth of axons and dendrites, selection of synaptic targets, and formation of functional synapses use neuronal surface receptors and their interactions with other surface receptors, secreted ligands, and matrix molecules. Spatiotemporal regulation of the expression of these receptors and cues allows for specificity in the developmental pathways that wire stereotyped circuits. The families of molecules controlling axon guidance and synapse formation are generally conserved across animals, with some important exceptions, which have consequences for neuronal connectivity. Here, we summarize the distribution of such molecules across multiple taxa, with a focus on model organisms, evolutionary processes that led to the multitude of such molecules, and functional consequences for the diversification or loss of these receptors.

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“…The three overexpression interventions each showed a positive effect on the number of regenerating axons out to 1.5mm from the crush site (Figure 8C, D) and also enhanced RGC survival (Figure 8E, F). Interestingly, among predicted targets of Wt1, nearly 20% (9/52) were membrane-associated genes implicated in axon outgrowth, such as Chl1, Cntn2 (Katic et al, 2014;Suter et al, 2020) (Table S6), underlining its potential role as a regulator for axon regeneration. In contrast, although Atf3, Atf4, Ddit3 and Cebpg all enhance survival following ONC (Tian et al; accompanying paper), they had no effect on regeneration driven by Pten deletion (Figure.…”

Section: Regeneration-associated Genes Promote Axon Regenerationmentioning

confidence: 99%

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

Jacobi

Tran

Yan

et al. 2022

Preprint

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Injured neurons in the adult mammalian central nervous system often die and seldom regenerate axons. To uncover transcriptional pathways that could ameliorate these disappointing responses we analyzed three interventions that increase survival and regeneration of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC) injury, albeit not to a clinically useful extent. We assessed gene expression in each of 46 RGC types by single cell transcriptomics following ONC and treatment. We also compared RGCs that regenerated to those that survived but did not regenerate. Each intervention enhanced survival of most RGC types, but type-independent axon regeneration required manipulation of multiple pathways. Distinct computational methods converged on separate sets of genes selectively expressed by RGCs likely to be dying, surviving, or regenerating. Overexpression of genes associated with the regeneration program enhanced axon regeneration in vivo, indicating that mechanistic analysis can be used to identify novel methods for promoting regeneration of injured neurons.

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TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation

Cited by 17 publications

References 77 publications

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

Structure and evolution of neuronal wiring receptors and ligands

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

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