TAFRO syndrome with fatigue and abdominal distension as the first symptom: A case report

Abstract

TAFRO syndrome is a peculiar and rare type of multi‐centric Castleman's disease which contained a series of symptoms such as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Here we provide a case of TAFRO syndrome with the manifestation of fatigue, abdominal distension, and low fever at primary diagnosis, characterized by multiple lymphadenopathy of superficial mediastinal and retroperitoneal lymph nodes, and it was finally confirmed by lymph node biopsy. The patient recovered speedy after receiving CHOP chemotherapy. In this case report, the patient has a history of dust‐exposure and hepatitis B virus infection, which may be potentially related to the disease. In addition, this case suggests the importance of pathological biopsy of complete lymph nodes in diagnostic process.

TAFRO syndrome: A disease that known is half cured

“…The efficacy of rituximab has also been verified in pediatric patients. 68 Some case reports have shown that the use of the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), 69,70 as used for invasive B-cell lymphoma, can inhibit an overactivated immune system and prevent the occurrence of a cytokine storm. In a retrospective study from China, five patients received CHOP/COP-like chemotherapy as the first-line treatment, among whom two patients also received rituximab; all patients eventually died due to disease progression and drug-related toxicity.…”