Marie-Claire Delfini, Annabelle Mantilleri, Stéphane Gaillard, Jizhe Hao, Ana Reynders, Pascale Malapert, Serge Alonso, Amaury François, Christian Barrere, Rebecca Seal, Marc Landry, Alain Eschallier, Abdelkrim Alloui, Emmanuel Bourinet et al.
Abstract:C-low-threshold mechanoreceptors (C-LTMRs) are unique among C-unmyelinated primary sensory neurons. These neurons convey two opposite aspects of touch sensation: a sensation of pleasantness, and a sensation of injury-induced mechanical pain. Here, we show that TAFA4 is a specific marker of C-LTMRs. Genetic labeling in combination with electrophysiological recordings show that TAFA4+ neurons have intrinsic properties of mechano-nociceptors. TAFA4-null mice exhibit enhanced mechanical and chemical hypersensitivi…
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