Taeniasis and Cysticercosis

Ferrer, Elizabeth; Perteguer, María Jesús

doi:10.1007/978-3-031-00303-5_9

Cited by 1 publication

(3 citation statements)

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“…LLGP-EITB has 100% specificity and is confirmed overall sensitivity of 98%. The introduction of monoclonal antibodies-based antigen detection by ELISA is an encouraging approach for cysticercosis diagnosis (Ferrer and Perteguer 2022). Antigen detection is limited to patients with clinically presented infection and is possible for patients with multiple cysts, predominantly those located in the subarachnoid space or the ventricular system (Del Brutto 2022).…”

Section: Classical Serology Diagnosismentioning

confidence: 99%

“…Low molecular weight metacestode secretion proteins, and especially glycoproteins, have shown the best performances in NC diagnosis assays. Thus, 14-and 18-kDa antigens and 8kDa-30kDa protein fraction have been described as the best alternative for developing an antibody detection system ruled at detection of NC (Ferrer and Perteguer 2022). Recent progress in NC serodiagnosis has resulted in two different types of antigenic platforms:  Chimeric protein fused with defined molecules with different epitope specificities  Multi-antigen print immunoassay that uses different antigens as a mixture (Hancock et al 2006).…”

Section: Classical Serology Diagnosismentioning

confidence: 99%

“…Of all these proteins, TsRS1 has 100% sensitivity and 100% specificity, when tested with cysticercosis-positive sera (previously reactive with the 8-kDa proteins) on WB, and Ts18 var1 and Ts18 var3 show 97% sensitivity and 100% specificity were selected for a future diagnostic antigen mixture. Recently, NC41 synthetic peptide was evaluated for NC diagnosing with high diagnostic performance (Ferrer and Perteguer 2022).…”

Section: Classical Serology Diagnosismentioning

confidence: 99%

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Recent Advances in Diagnosing of Human Cysticercosis

2023

IJAB

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Cysticercosis in humans is a parasitic disease caused by Cysticercus (C.) cellulosae, the larval stage (known as metacestode) of the Cyclophyllidean tapeworm Taenia (T.) solium. It is a highly prevalent infection in India, China, the Southern part of the African continent, South America, the Central American region of North America, and a few Eastern European countries. T. solium (neuro cysticercosis, NC) causes a zoonotic disease complex. According to many authors NC is considered as one of the most important food-borne zoonotic diseases respectively, caused by helminth parasite. Accurate and prompt diagnosis is essential for early detection and effective treatment of the disease. Diagnostic approaches including: Direct Detection of metacestodes and tissue lesions in CNS and soft tissues; Various Imaging Techniques like: CT, MRI, Ultrasonography (US) and Xray; Classical and Rapid Serology tests and Molecular techniques. Neuroimaging by CT or MRI is critical in the diagnosis of neurocysticercosis. MRI is more expensive but is becoming more accessible in developing countries often provides a clearer picture of cysticerci and has greater sensitivity for multiple lesions. Serological testing provides important confirmatory data for patients with suspicious lesions on CT or MRI. Serological testing has improved, with a sensitivity of 98% and a specificity approaching 100%. The electro-immune-transfer blot (western blot) assay using lentil lectin purified glycoprotein antigens (LLGP-EITB) is preferable to the ELISA for the identification of anti-cysticercal antibodies in human serum. Low molecular weight metacestode secretion proteins, and especially glycoproteins, have shown the best performances in NC diagnosis assays. The LAMP (loop-mediated isothermal amplification technique) test would be a very useful tool to contribute to reducing the incidence of cysticercosis in developing countries, except when the cysticerci are calcified, because in that case no circulating antigens are available. Ideally both ways are used, combining the advantage of the higher sensitivity of MRI with CT detection of calcium. Identifying of human cysticercosis is possible by collecting and analyzing laboratory results and clinical/epidemiological data strictly following Del Brutto's revised diagnostic criteria.

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Section: Classical Serology Diagnosismentioning

confidence: 99%

Section: Classical Serology Diagnosismentioning

confidence: 99%

Section: Classical Serology Diagnosismentioning

confidence: 99%

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