Taenia solium tapeworms synthesize corticosteroids and sex steroids in vitro

Valdéz, Ricardo; Jiménez, Pedro; Presas, Ana María Fernández; Aguilar, Laura; Willms, Kaethe; Romano, Marta

doi:10.1016/j.ygcen.2014.04.014

Cited by 5 publications

(5 citation statements)

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“…In addition, the parasites synthesized corticosterone, which was measured by radioimmunoassay in the culture media. More recently, we found corticosteroid-like synthesis in Taenia solium tapeworms (Valdez et al, 2014 ). It had been shown that in the adrenal reticular zone of mammals an excess of progesterone can be inactivated by 20HSD activity (Pelletier et al, 2005 ) and that cortisol and corticosterone can be inactivated by 11β-hydroxylase in the adrenal glomerulose zone (for a review see Odermatt and Atanasov, 2009 ) but to our knowledge these enzymes had not been investigated in Taenia solium or crassiceps WFU organisms.…”

Section: Parasites Synthesize Steroid Hormonesmentioning

confidence: 74%

“…Taenia crassiceps WFU tapeworms were incubated in the presence of 3 H-DHEA and tritiated androstenediol and 17β-estradiol where recovered from the culture media, which strongly suggest the presence and activity of enzymes from the Δ5 steroid pathway in these tapeworms (Fernández Presas et al, 2008 ). Taenia solium tapeworms kept in culture also synthesized sex steroids (Valdez et al, 2014 ).…”

Section: Parasites Synthesize Steroid Hormonesmentioning

confidence: 99%

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Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development

et al. 2015

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In many cases parasites display highly complex life cycles that include the penetration and permanence of the larva or adults within host organs, but even in those that only have one host, reciprocal, intricate interactions occur. Evidence indicates that steroid hormones have an influence on the development and course of parasitic infections. The host gender's susceptibility to infection, and the related differences in the immune response are good examples of the host-parasite interplay. However, the capacity of these organisms to synthesize their own steroidogenic hormones still has more questions than answers. It is now well-known that many parasites synthesize ecdysteroids, but limited information is available on sex steroid and corticosteroid synthesis. This review intends to summarize some of the existing information in the field. In most, but not all parasitosis the host's hormonal environment determines the susceptibility, the course, and severity of parasite infections. In most cases the infection disturbs the host environment, and activates immune responses that end up affecting the endocrine system. Furthermore, sex steroids and corticosteroids may also directly modify the parasite reproduction and molting. Available information indicates that parasites synthesize some steroid hormones, such as ecdysteroids and sex steroids, and the presence and activity of related enzymes have been demonstrated. More recently, the synthesis of corticosteroid-like compounds has been shown in Taenia solium cysticerci and tapeworms, and in Taenia crassiceps WFU cysticerci. In-depth knowledge of the parasite's endocrine properties will contribute to understand their reproduction and reciprocal interactions with the host, and may also help designing tools to combat the infection in some clinical situations.

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Section: Parasites Synthesize Steroid Hormonesmentioning

confidence: 74%

Section: Parasites Synthesize Steroid Hormonesmentioning

confidence: 99%

Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development

et al. 2015

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“…In fact, it was demonstrated that adrenal hormones exert a profound effect on several parasites determining the susceptibility, the course and severity of parasite infections (Escobedo et al, 2004, Romano et al, 2015). In most cases the infection disturbs the host environment, activates immune responses that end up affecting the endocrine system (Valdez et al, 2006, Valdez et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Hair cortisol and dehydroepiandrosterone concentrations in naturally Taenia solium infected pigs in Tanzania

Trevisan

Montillo

Prandi

et al. 2017

General and Comparative Endocrinology

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“…In addition, the parasites synthesized corticosterone, which was measured by radioimmunoassay in the culture media. More recently, we found corticosteroid-like synthesis in T. s o l i u m and T. crassiceps tapeworms [24,25]. To note, the steroidogenic capacity of T. crassiceps is related to the development of the parasite [24].…”

Section: Sex Steroids and Corticosteroidsmentioning

confidence: 83%

Hormones and Parasites, Their Role in Taenia solium and Taenia crassiceps Physiology and Development

Romano¹,

Valdéz²,

Patricio³

et al. 2021

Current State of the Art in Cysticercosis and Neurocysticercosis

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The host’s hormonal environment determines the susceptibility, the course, and severity of several parasite infections. In most cases the infection disturbs the host environment, and activates immune responses that end up affecting the endocrine system. In the other hand, a number of reports indicate that parasites have reproductive systems, and some others have shown that these organisms synthetize sex steroid hormones. We have shown that cysticerci, the larval stage of Taenia solium and Taenia crassiceps ORF and WFU, synthesize steroid hormones. This capacity was modified by drugs that act inhibiting the steroid synthesizing enzymes, or blocking the parasite’s hormone receptors. We have also shown that the cysticerci of T. crassiceps WFU and T. solium have the capacity to synthesize corticosteroids as deoxicorticosterone and corticosterone. We also reviewed the effects of insulin on these parasites, and the receptors found for this hormone. A deep knowledge of the parasite’s endocrine properties will contribute to understand their reproduction and the reciprocal interactions with the host. Likewise, may also help designing tools to combat the infection in clinical situations.

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Taenia solium tapeworms synthesize corticosteroids and sex steroids in vitro

Cited by 5 publications

References 39 publications

Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development

Parasites and steroid hormones: corticosteroid and sex steroid synthesis, their role in the parasite physiology and development

Hair cortisol and dehydroepiandrosterone concentrations in naturally Taenia solium infected pigs in Tanzania

Hormones and Parasites, Their Role in Taenia solium and Taenia crassiceps Physiology and Development

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