Taenia solium Metacestode Factor as Probable Cause of Temporal Lobe Epilepsy

Abstract

This article analyzes data from scientific publications (mainly reviews) concerning the link between human neurocysticercosis and epilepsy. Along with data from our own studies on experimental hippocampal sclerosis induced by a Taenia crassiceps metacestode factor in mice, it explores the connection between mechanisms that likely favor the development of epilepsy in cases of human neurocysticercosis. The data from both sources suggest the idea that the T. solium metacestode factor causes hippocampal sclerosis and later epilepsy in humans with neurocysticercosis.

Cellular and molecular basis associated with metacestode proliferation in subarachnoid neurocysticercosis

“…MicroRNAs have a significant role in the control of gene expression, and alterations in the expression levels of some host microRNAs are associated with seizures and epilepsy ( 13 ). It is not surprising to consider that some microRNAs would have active participation during NCC ( 14 ). The identification of microRNAs secreted by the parasite allows us to understand new pathways of action on the host; they also constitute potential markers for the diagnosis of the disease and the follow-up of patients after the initiation of anthelmintic treatment.…”