Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation–predominant irritable bowel syndrome

Sedky, Amina Ahmed; Magdy, Yosra

doi:10.1016/j.lfs.2020.117960

Cited by 9 publications

(10 citation statements)

References 21 publications

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“…There are few studies evaluating the effects of tadalafil on healthy athletes [ 27 , 53 , 54 , 55 ]. Many studies have been conducted on subjects with pathologies or who are in conditions of extreme physiological stress [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. Recently, using a similar group of subjects, we have demonstrated that a single dose of tadalafil did not substantially influence performance indicators, during a maximal standardized exercise test in a healthy athlete [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity

Duranti

Ceci

Luigi

et al. 2021

IJERPH

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Background: The phosphodiesterase type 5 inhibitor (PDE5I) tadalafil, in addition to its therapeutic role, has shown antioxidant effects in different in vivo models. Supplementation with antioxidants has received interest as a suitable tool for preventing or reducing exercise-related oxidative stress, possibly leading to the improvement of sport performance in athletes. However, the use/abuse of these substances must be evaluated not only within the context of amateur sport, but especially in competitions where elite athletes are more exposed to stressful physical practice. To date, very few human studies have addressed the influence of the administration of PDE5Is on redox balance in subjects with a fitness level comparable to elite athletes; therefore, the aim of this study was to investigate for the first time whether acute ingestion of tadalafil could affect plasma markers related to cellular damage, redox homeostasis, and blood polyamines levels in healthy subjects with an elevated cardiorespiratory fitness level. Methods: Healthy male volunteers (n = 12), with a VO2max range of 40.1–56.0 mL/(kg × min), were administered with a single dose of tadalafil (20 mg). Plasma molecules related to muscle damage and redox-homeostasis, such as creatine kinase (CK), lactate dehydrogenase (LDH), total antioxidant capacity (TAC), reduced/oxidized glutathione ratio (GSH/GSSG), free thiols (FTH), antioxidant enzyme activities (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), as well as thiobarbituric acid reactive substances (TBARs), protein carbonyls (PrCAR), and polyamine levels (spermine (Spm) and spermidine (Spd)) were evaluated immediately before and 2, 6 and 24 hours after the acute tadalafil administration. Results: A single tadalafil administration induced an increase in CK and LDH plasma levels 24 after consumption. No effects were observed on redox homeostasis or antioxidant enzyme activities, and neither were they observed on the oxidation target molecules or polyamines levels. Conclusion: Our results show that in subjects with an elevated fitness level, a single administration of tadalafil induced a significant increase in muscle damage target without affecting plasma antioxidant status.

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Section: Discussionmentioning

confidence: 99%

Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity

Duranti

Ceci

Luigi

et al. 2021

IJERPH

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“…Three rats of each group were separated for measurement of the intestinal transit and cGMP level. According to the literature the intestinal transit was measured by administration of powdered charcoal via gastric gavage ( Sagar et al, 2005 , Sedky and Magdy, 2020 , Sharman et al, 2017 ). After one hour; they were sacrificed and the small and large intestines were isolated.…”

Section: Methodsmentioning

confidence: 99%

“…In 2012, linaclotide; GC-C agonist, gained FDA approval for the treatment of constipation-predominant IBS ( Eswaran et al, 2014 , Love et al, 2014 ). However, the use of GC-C agonists in pediatrics was limited as they may cause severe diarrhea ( Sedky and Magdy, 2020 ). cGMP-elevating agents such as phosphodiesterase 5 (PDE-5) inhibitors are recently reported as a promising medication in pediatrics ( Eswaran et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…Vardenafil (VDF) is a selective inhibitor for PDE-5 used in management of impotence. Nonetheless, recent reports have emphasized the potential use of PDE-5 inhibitors; Sildenafil and Tadalafil, for treatment of IBS ( Sedky and Magdy, 2020 , Sharman et al, 2017 ). VDF acts by inhibiting PDE-5 thus protecting cGMP from hydrolysis, and consequently, the increment in serum cGMP levels, which in turn, can lead to smooth muscle vasodilation and thus could be beneficious to treat constipation-predominant IBS in children.…”

Section: Introductionmentioning

confidence: 99%

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Vardenafil oral jellies as a potential approach for management of pediatric irritable bowel syndrome

Gomaa

Ayoub

2021

Saudi Pharmaceutical Journal

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“…Applic. 33, No.1 (2020) bowel syndrome besides the related behavior deviations (Sedky & Magdy, 2020;Singh et al, 2020;Zuccarello et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Tadalafil Attenuates γ-Rays-Induced Hepatic Injury in Rats

Khouly

Ebrahim

2020

Egypt. J. Rad.Sci.

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T ADALAFIL is widely used in the treatment of many disease disorders. Tadalafil is studied for its protective effect against γ-rays-induced hepatic injury in rats. Rats were exposed to 6 Gy-γ-rays then, treated with Tadalafil for 7-days and compared to the control, Tadalafil alone and irradiated groups. Oxidative-stress markers; malondialdehyde (MAD) and myeloperoxidase (MPO) and the antioxidant markers; reduced glutathione (GSH) content, and the relative enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated in liver tissues. The anti-inflammatory markers; tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were evaluated in the blood serum. Data revealed a significant reduction in the γ-rays-induced lipid-peroxidation; MDA content, MPO activity, the inflammatory markers levels of TNF-α and IL-6, and an augmentation in the antioxidant marker levels of GSH, GPx, CAT and SOD. It could be concluded that Tadalafil could alleviate the toxic effects of ionizing radiation in liver via the strong anti-oxidant and anti-inflammatory impact, thus could be useful as a radio protective agent in the radiotherapy schedule. The radio protective influence of Tadalafil could need to be explored for further organs in imminent works.

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Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation–predominant irritable bowel syndrome

Cited by 9 publications

References 21 publications

Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity

Effect of Tadalafil Administration on Redox Homeostasis and Polyamine Levels in Healthy Men with High Level of Physical Activity

Vardenafil oral jellies as a potential approach for management of pediatric irritable bowel syndrome

Tadalafil Attenuates γ-Rays-Induced Hepatic Injury in Rats

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