Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies
Shintaro Maki,
Sho Takakura,
Makoto Tsuji
et al.
Abstract:Fetal growth restriction (FGR) is a major concern in perinatal care. Various medications have been proposed as potential treatments for this serious condition. Nonetheless, there is still no definitive treatment. We studied tadalafil, a phosphodiesterase-5 inhibitor, as a therapeutic agent for FGR in clinical studies and animal experiments. In this review, we summarize our preclinical and clinical data on the use of tadalafil for FGR. Our studies in mouse models indicated that tadalafil improved FGR and hypert… Show more
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