Tactile stimulation partially prevents neurodevelopmental changes in visual tract caused by early iron deficiency

Horiquini-Barbosa, Everton; Gibb, Robbin; Kolb, Bryan; Bray, D. F.; Lachat, João José

doi:10.1016/j.brainres.2016.12.003

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…Similar neuroanatomical changes and improved motor function were observed after tactile stimulation (3x daily for 15 min) in different models of brain injury (frontal and somatosensory cortex) (Gibb et al, 2010). Tactile stimulation (3 min/day for 33 days) also resulted in reversal of some optic nerve cytoarchitecture changes caused by early iron deficiency (Horiquini-Barbosa et al, 2017).…”

Section: Gene Expressionsupporting

confidence: 63%

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

2020

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Background: Physiological responses related to manual therapy (MT) treatment have been investigated over decades using various animal models. However, these studies have not been compiled and their collective findings appraised. The purpose of this scoping review was to assess current scientific knowledge on the physiological responses related to MT and/or simulated MT procedures in animal models so as to act as a resource to better inform future mechanistic and clinical research incorporating these therapeutic interventions. Methods: PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane, Embase, and Index of Chiropractic Literature (ICL) were searched from database inception to August 2019. Eligible studies were: (a) published in English; (b) non-cadaveric animal-based; (c) original data studies; (d) included a form of MT or simulated MT as treatment; (e) included quantification of at least one delivery parameter of MT treatment; (f) quantification of at least one physiological measure that could potentially contribute to therapeutic mechanisms of action of the MT. MT studies were categorized according to three main intervention types: (1) mobilization; (2) manipulation; and (3) massage. Two-phase screening procedures were conducted by a pair of independent reviewers, data were extracted from eligible studies and qualitatively reported.Results: The literature search resulted in 231 articles of which 78 met inclusion criteria and were sorted by intervention type. Joint mobilization induced changes in nociceptive response and inflammatory profile, gene expression, receptor activation, neurotransmitter release and enzymatic activity. Spinal manipulation produced changes in muscle spindle response, nocifensive reflex response and neuronal activity, electromyography, and immunologic response. Physiological changes associated with massage therapy included autonomic, circulatory, lymphatic and immunologic functions, visceral response, gene expression, neuroanatomy, function and pathology, and cellular response to in vitro simulated massage. Conclusion:Pre-clinical research supports an association between MT physiological response and multiple potential short-term MT therapeutic mechanisms. Optimization Lima et al.Manual Therapy in Animal Models of MT delivery and/or treatment efficacy will require additional preclinical investigation in which MT delivery parameters are controlled and reported using pathological and/or chronic pain models that mimic neuromusculoskeletal conditions for which MT has demonstrated clinical benefit.

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Section: Gene Expressionsupporting

confidence: 63%

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

2020

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“…In the rat, myelination in peripheral nerves is most rapid across the first 10 PNDs, compared with across PNDs 20–30 (Friede and Samorajski, ; Webster, ). In agreement with the present results, a recent study reported that tactile stimulation during the entire postnatal preweaning period increased oligodendrocyte density in the optic nerve (Horiquini‐Barbosa and Lachat, ) and prevent the iron‐deficiency disruption in oligodendrocytes and myelinated fiber density in the optic nerve (Horiquini‐Barbosa et al, ).…”

Section: Discussionsupporting

confidence: 92%

Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation

Zempoalteca

Porras²,

Moreno-Pérez

et al. 2017

Developmental Neurobiology

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Early adverse experiences disrupt brain development and behavior, but little is known about how such experiences impact on the development of the peripheral nervous system. Recently, we found alterations in the electrophysiological and histological characteristics of the sensory sural (SU) nerve in maternally deprived, artificially reared (AR) adult male rats, as compared with maternally reared (MR) control rats. In the present study, our aim was to characterize the ontogeny of these alterations. Thus, male pups of four postnatal days (PND) were (1) AR group, (2) AR and received daily tactile stimulation to the body and anogenital region (AR-Tactile group); or (3) reared by their mother (MR group). At PND 7, 14, or 21, electrophysiological properties and histological characteristics of the SU nerves were assessed. At PND 7, the electrophysiological properties and most histological parameters of the SU nerve did not differ among MR, AR, and AR-Tactile groups. By contrast, at PND 14 and/or 21, the SU nerve of AR rats showed a lower CAP amplitude and area, and a significant reduction in myelin area and myelin thickness, which were accompanied by a reduction in axon area (day 21 only) compared to the nerves of MR rats. Tactile stimulation (AR-Tactile group) partially prevented most of these alterations. These results suggest that sensory cues from the mother and/or littermates during the first 7-14 PND are relevant for the proper development and function of the adult SU nerve. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 351-362, 2018.

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“…A more specific analysis of iron deficient brains showed decreases in neocortical area and thickness, corpus callosum area and rostro-caudal callosal length, with a high effect size, compared with iron sufficient brains. This confirms reports about similar results (Horiquini-Barbosa et al, 2017; Horiquini-Barbosa, Gibb, Kolb, Bray, & Lachat, 2020; Romand et al, 2011; Yu, Steinkirchner, Rao, & Larkin, 1986;). In general, adult Fe+ rats usually present no differences between male and female morphological measurements except for the females exhibiting a lighter brain, a gender difference which may be explained by the fact males have greater cellular density while females have more neuronal processes (Rabinowicz, Dean, Petetot, & de Courten-Myers, 1999).…”

Section: Discussionsupporting

confidence: 92%

“…During neurodevelopment, the brain demands substantial iron import and this micronutrient is necessary for several molecular and cellular processes, such as DNA, RNA and protein synthesis, cell proliferation and differentiation (Beard, 2003; Beard, Connor, & Jones, 1993). Iron demand increases during the critical period of neurodevelopment, and its deficiency causes multiple acute and long-term structural (DeMaman, Melo, Homem, Tavares, & Lachat, 2010; Horiquini-Barbosa, Gibb, Kolb, Bray, & Lachat, 2017), ultrastructural (DeMaman et al, 2010; Horiquini-Barbosa et al, 2017), electrophysiological (Rocinholi, Lachat, & Oliveira, 2008), and neurochemical changes (Beard, 2003). Recently, iron deficiency was related to gene and epigenetic dysregulation (Tran, Kennedy, Lien, Simmons, & Georgieff, 2015; Tran et al, 2016).…”

mentioning

confidence: 99%

Late effects of iron deficiency during gestation and lactation followed by iron replacement on anxiety-related behaviors and brain morphology of young adult rats.

Bonuti¹,

Horiquini-Barbosa²,

Morato³

2020

Psychology & Neuroscience

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Introduction: Iron deficiency during critical periods has long-lasting impact on brain structure and function, suggesting an iron-sensitive early developmental window. Objectives: We aimed at investigating anxiety-related behavior and neuroanatomical parameters of adult male and female rats exposed to iron deficiency during the fetal and lactational periods and eventual benefits of iron replacement for 50 days after weaning. Method: Female rats received diets either deficient or sufficient in iron content from the first day of pregnancy to weaning. One day after birth some pups had their bodies and brains weighed; remaining pups were weighed weekly and received the same iron sufficient diet their dams received until weaning. When adult, subjects were submitted to an open-field, an elevated plus-maze, a light/dark box and an elevated gradient of aversion. After testing they had their blood collected, their brains weighed and morphologically analyzed. Results: After birth, the brains of iron deficient males were smaller than that of their counterpart iron sufficient males and reduced body weight from the second week of life until the end of the experiment. Iron deficiency also caused behavior and neuroanatomical alterations interpreted as increased anxiety and decreased cortical and callosal size in both males and females submitted to the behavioral tests and to a battery of morphological measures. Conclusion: Even after iron replacement males and females exhibited smaller brains. Iron deficiency during gestation and lactation led to decreased brain weight, higher levels of anxiety and decreased cortical and callosal size, despite the recovery of hematological measures after weaning, due to a long-term iron replacement.

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Tactile stimulation partially prevents neurodevelopmental changes in visual tract caused by early iron deficiency

Cited by 9 publications

References 42 publications

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review

Early postnatal development of electrophysiological and histological properties of sensory sural nerves in male rats that were maternally deprived and artificially reared: Role of tactile stimulation

Late effects of iron deficiency during gestation and lactation followed by iron replacement on anxiety-related behaviors and brain morphology of young adult rats.

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