Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans

Hansson, Thomas; Brismar, Tom

doi:10.1016/s0304-3940(99)00508-x

Cited by 76 publications

(47 citation statements)

References 14 publications

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“…In support of an interhemispheric transfer of sensory information, neurons with bilateral receptive fields of the hands in monkeys, were not present following contralateral lesioning of the postcentral gyrus (Iwamura et al 1994). In addition to pain, tactile stimulation of the hand results in bilateral SI activation (Hansson and Brismar 1999); this was around 20% less than the contraleral effect, which was similar to that observed in our study for brush stimuli. Anatomical studies of corpus callosum connections indicated relatively sparse connections for the glabarous hand and foot compared with the face and trunk (Killackey et al 1983).…”

Section: Activation In the Somatosensory Regionsupporting

confidence: 90%

“…The single trial average responses after PCA filtering for all detectors are shown in Figure 2B for one subject. S1 activation was observed bilaterally to the same level of activation, a similar result obtained with other neuroimaging techniques (Hansson and Brismar 1999;Tracey et al 2000;Sutherland and Tang 2006). It is important to note that systemic effects were ruled out for each subject through the use of a head probe that maps a large area of the cortex.…”

Section: Heat Stimulationsupporting

confidence: 80%

“…Furthermore, some studies indicate bilateral activation with a prominent component contralateral to the stimulus (Hansson and Brismar 1999;Franceschini et al 2003) while others have found inhibition of ipsilateral activation (Hlushchuk and Hari, 2006). Taken together, these results seem to indicate that contralateral activation is routinely detected while concomitant ipsilateral is not sought, is activated at a lower level, or even suppressed.…”

Section: Activation In the Somatosensory Regionmentioning

confidence: 83%

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Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

et al. 2008

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Using Diffuse Optical Tomography (DOT) we detected activation in the somatosensory cortex and frontal brain areas following tactile (brush) and noxious heat stimulation. Healthy volunteers received stimulation to the dorsum of the right hand. In the somatosensory cortex area, tactile stimulation produced a robust, contralateral to the stimulus, hemodynamic response with a weaker activation on the ipsilateral side. For the same region, noxious thermal stimuli produced bilateral activation of similar intensity that had a prolonged activation with a two-peak similar to results have been reported with functional MRI. Bilateral activation was observed in the frontal areas, oxyhemoglobin changes were positive for brush stimulation while they were initially negative (contralateral) for heat stimulation. These results suggest that based on the temporal and spatial characteristics of the response in the sensory cortex, it is possible to discern painful from mechanical stimulation using DOT. Such ability might have potential applications in a clinical setting in which pain needs to be assessed objectively (e.g. analgesic efficacy, pain responses during surgery).

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Section: Activation In the Somatosensory Regionsupporting

confidence: 90%

Section: Heat Stimulationsupporting

confidence: 80%

Section: Activation In the Somatosensory Regionmentioning

confidence: 83%

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Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

et al. 2008

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“…The approximate anterior-posterior functional-anatomical location of the premotor cortex (PMC), SMA, primary motor (M1), and primary sensory (S1) cortical regions in each subject was determined by comparing previously reported MRI and fMRI studies activation locations 35,[59][60][61] with fNIRS results from the eight subjects in this study obtained during left hand sensory stimulation, finger tapping, and sequential finger tapping protocols (Sec. 2.4).…”

Section: Imaging With Fnirs and Tdcs Setupmentioning

confidence: 99%

Functional near-infrared spectroscopy maps cortical plasticity underlying altered motor performance induced by transcranial direct current stimulation

et al. 2013

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Abstract. Transcranial direct current stimulation (tDCS) of the human sensorimotor cortex during physical rehabilitation induces plasticity in the injured brain that improves motor performance. Bi-hemispheric tDCS is a noninvasive technique that modulates cortical activation by delivering weak current through a pair of anodal-cathodal (excitation-suppression) electrodes, placed on the scalp and centered over the primary motor cortex of each hemisphere. To quantify tDCS-induced plasticity during motor performance, sensorimotor cortical activity was mapped during an event-related, wrist flexion task by functional near-infrared spectroscopy (fNIRS) before, during, and after applying both possible bi-hemispheric tDCS montages in eight healthy adults. Additionally, torque applied to a lever device during isometric wrist flexion and surface electromyography measurements of major muscle group activity in both arms were acquired concurrently with fNIRS. This multiparameter approach found that hemispheric suppression contralateral to wrist flexion changed resting-state connectivity from intra-hemispheric to inter-hemispheric and increased flexion speed (p < 0.05). Conversely, exciting this hemisphere increased opposing muscle output resulting in a decrease in speed but an increase in accuracy (p < 0.05 for both). The findings of this work suggest that tDCS with fNIRS and concurrent multimotor measurements can provide insights into how neuroplasticity changes muscle output, which could find future use in guiding motor rehabilitation. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…However, fMRI has proved to be a very powerful tool for neuroscience research and has been used to study how sensory information is transmitted and processed in the cortex, in both healthy individuals and in clinical populations. [2][3][4] However, there remains a gap in our understanding of how sensory information is relayed and processed from the spinal cord to the brain stem, both of which are essential for the normal perception of sensory information. To obtain a consistent and complete understanding of how this information is transmitted from the periphery to the cortex, and how injury or disease can alter this transmission, it is necessary to study the entire central nervous system from the first synapse in the spinal cord to the processing centers in the brain stem.…”

mentioning

confidence: 99%

Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging

Ghazni¹,

Cahill²,

Stroman³

2009

AJNR Am J Neuroradiol

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Tactile stimulation of the hand causes bilateral cortical activation: a functional magnetic resonance study in humans

Cited by 76 publications

References 14 publications

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

Functional near-infrared spectroscopy maps cortical plasticity underlying altered motor performance induced by transcranial direct current stimulation

Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging

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