Tactile Corpuscle-Like Bodies in Colonic Mucosa

Wills, E. J.; Croker, J. R.; Brammah, Susan

doi:10.1080/01913120309926

Cited by 12 publications

(36 citation statements)

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“…3 The hypotheses on this lesion are various as reactive, neoplastic, or amartomatous. 1 The reactive nature of the proliferation was supposed because the first 2 cases described at gastric and colonic level were associated with the presence of an adenocarcinoma 4,5 ; this hypothesis was not confirmed in subsequent and more numerous observations, 1-3 as in our case, where these corpuscles were present in the normal context of gastric or colonic mucosa.…”

Section: Discussioncontrasting

confidence: 75%

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Wagner-Meissner–Like Corpuscles in Gastric Mucosa

et al. 2014

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Wagner-Meissner corpuscles are touch receptors that are located in dermal papillae and are usually absent in gastrointestinal mucosa. Wagner-Meissner-like corpuscles have been reported in association with benign neural neoplasm. A case of Wagner-Meissner-like corpuscles in endoscopically normal gastric mucosa biopsy of a 48-year-old woman is presented here. The corpuscles were positive for S-100 and clinical evidence of neurofibromatosis was negative. From a review of the literature, only 2 cases of tactile corpuscle-like structures in gastric mucosa are available.

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Section: Discussioncontrasting

confidence: 75%

“…The majority were observed in the colon and rectum. 1,[3][4][5] Here, we report a case of Wagner-Meissner-like corpuscles detected in gastric mucosa biopsy specimens and literature review.…”

Section: Introductionmentioning

confidence: 99%

Wagner-Meissner–Like Corpuscles in Gastric Mucosa

et al. 2014

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“…Whether TCLB is reparative or neoplastic remains unclear: the first 2 reported cases could suggest a relationship of TCLB with neoplasia 7,8 ; however, that association would seem coincidental with experience with additional examples. Some observers have suggested that these structures in the GI mucosa might represent part of the morphologic spectrum of Schwann cell hamartoma, 17 which, like TCLB, is an incidental finding of no real clinical significance.…”

Section: Discussionmentioning

confidence: 70%

“…3,11 Nonsyndromic TCLBs have been described only rarely in the GI tract-type mucosa. The initial description was by Wills et al, 8 who reported an incidental colonic In the present study, we analyzed a series of 9 TCLB cases identified as incidental findings. On the basis of the literature and the 9 cases presented herein, TCLB always arise in the lamina propria.…”

Section: Discussionmentioning

confidence: 98%

“…1,5 Their presence in the GI tract is rare: only 13 cases have been reported in the English literature. 1,2,[6][7][8][9] Herein, we present 9 new cases of tactile corpusclelike bodies in GI-type mucosa of patients without syndromic association. For the sake of simplicity, henceforth we will use the tactile corpuscle-like bodies (TCLB) terminology.…”

Section: Introductionmentioning

confidence: 99%

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Tactile Corpuscle-like Bodies in Gastrointestinal-type Mucosa

Celeiro-Muñoz¹,

Huebner

Robertson

et al. 2015

American Journal of Surgical Pathology

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Tactile corpuscle-like bodies (TCLB) are microscopic Schwannian structures that simulate the superficial mechanoreceptors of the peripheral nervous system (Wagner-Meissner corpuscles). They have been described nearly exclusively in peripheral nerve sheath tumors, namely diffuse neurofibromas, and schwannomas but also in cellular nevi. There are rare reports of these structures in the gastrointestinal tract (predominantly the lower tract), with the presumption that they are incidental reactive neural proliferations. We compiled 9 cases showing this rare phenomenon in gastrointestinal-type mucosa in nonsyndromic patients to further characterize its features. There were 6 men and 3 women (age range, 39 to 79 y, mean 56 y) with lesions involving esophagus/gastro-esophageal junction (n=7), sigmoid colon (n=1), and gastric heterotopia of the cricopharynx (n=1). Endoscopic examination was abnormal in 6 of the 7 cases (including changes consistent with Barrett esophagus and polypoid/nodular mucosa) and normal in 1 of 7 cases for which this information was available. The histologic features were similar in all cases, with unencapsulated clusters of lamellated and concentrically arranged spindle cells in the lamina propria. The foci of TCLB ranged in size from <0.1 to 1.5 mm in the greatest dimension. Abnormal histopathologic findings were identified in the background mucosa in 6 of 9 cases (including Barrett esophagus, active and inactive chronic gastritis, enterochromaffin-like cell hyperplasia, and gastric intestinal metaplasia). None of the patients showed signs of neurofibromatosis type 1, multiple endocrine neoplasia type 2B, Cowden syndrome, or other inherited syndrome. No morbidity related to TCLB was reported for the patients with available follow-up.

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Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma

Grech

Schofield

2020

Histopathology

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A wide range of spindle cell proliferations are found uncommonly in the sigmoid colon, rectum and anus. They usually present as polyps, and include reactive lesions and benign and malignant neoplasms which may be primary or metastatic. They are less frequently described in the literature compared to those in the upper gastrointestinal tract, and may be underdiagnosed. The widespread use of sigmoidoscopy in symptomatic patients and bowel cancer screening programmes means that histopathologists must be aware of, and adopt a logical approach to, diagnosing spindle cell proliferations in biopsy and polypectomy specimens. This is particularly relevant given the strong association of some mesenchymal polyps with hereditary cancer syndromes. This review article will focus on perineurioma and the recent debate in relation to its overlap with fibroblastic polyp. The clinical, endoscopic, histological and immunohistochemical features of spindle cell proliferations which should be considered in the differential diagnosis of perineurioma will be discussed. There is also a brief reference to malignant spindle cell tumours of diagnostic importance.

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Tactile Corpuscle-Like Bodies in Colonic Mucosa

Cited by 12 publications

References 0 publications

Wagner-Meissner–Like Corpuscles in Gastric Mucosa

Wagner-Meissner–Like Corpuscles in Gastric Mucosa

Tactile Corpuscle-like Bodies in Gastrointestinal-type Mucosa

Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma

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