Tactile coactivation resets age‐related decline of human tactile discrimination

Dinse, Hubert R.; Kleibel, Nadine; Kalisch, Tobias; Ragert, Patrick; Wilimzig, Claudia; Tegenthoff, Martin

doi:10.1002/ana.20862

Cited by 119 publications

(154 citation statements)

References 36 publications

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“…In contrast, ratios Ͻ1 were found in both young and elderly individuals, although tactile discrimination differed substantially between young and elderly subjects (Stevens, 1992;Woodward, 1993;Wohlert, 1996;Dinse et al, 2006;Kalisch et al, 2009). Accordingly, the close association between paired-pulse suppression and discrimination performance discussed above appears limited to elderly subjects.…”

Section: Discussionmentioning

confidence: 85%

Increased Excitability of Somatosensory Cortex in Aged Humans is Associated with Impaired Tactile Acuity

Lenz¹,

Tegenthoff²,

Kohlhaas³

et al. 2012

J. Neurosci.

105

112

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Aging affects all levels of neural processing, including changes of intracortical inhibition and cortical excitability. Paired-pulse stimulation, the application of two stimuli in close succession, is a useful tool to investigate cortical excitability in humans. The paired-pulse behavior is characterized by the second response being significantly suppressed at short stimulus onset asynchronies. While in rat somatosensory cortex, intracortical inhibition has been demonstrated to decline with increasing age, data from human motor cortex of elderly subjects are controversial and there are no data for the human somatosensory cortex (SI). Moreover, behavioral implications of age-related changes of cortical excitability remain elusive. We therefore assessed SI excitability by combining paired-pulse median nerve stimulation with recording somatosensory evoked potentials in 138 healthy subjects aged 17-86 years. We found that paired-pulse suppression was characterized by substantial interindividual variability, but declined significantly with age, confirming reduced intracortical inhibition in elderly subjects. To link the age-related increase of cortical excitability to perceptual changes, we measured tactile two-point discrimination in a subsample of 26 aged participants who showed either low or high paired-pulse suppression. We found that tactile performance was particularly impaired in subjects showing markedly enhanced cortical excitability. Our data demonstrate that paired-pulse suppression of human SI is significantly reduced in older adults, and that age-related enhancement of cortical excitability correlates with degradation of tactile perception. These findings indicate that cortical excitability constitutes an important mechanism that links age-related neurophysiological changes to behavioral alterations in humans.

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Section: Discussionmentioning

confidence: 85%

Increased Excitability of Somatosensory Cortex in Aged Humans is Associated with Impaired Tactile Acuity

Lenz¹,

Tegenthoff²,

Kohlhaas³

et al. 2012

J. Neurosci.

105

112

View full text Add to dashboard Cite

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“…Especially baseline performance predicted participant's improvement. It has been found to negatively correlate with the stimulation induced improvement (Dinse et al, 2006;Reuter et al, unpublished) (Dinse, 2006).…”

Section: Relation To Baseline Performancementioning

confidence: 99%

“…Ceiling effects probably play an important role in this relationship (Dinse, 2006). A very good performance in the first session might leave very little room for improvement.…”

Section: Relation To Baseline Performancementioning

confidence: 99%

“…Dinse et al, 2006;Höffken et al, 2007;Kalisch et al, 2007;Kalisch et al, 2008;Pilz, Veit, Braun, & Godde, 2004), or rather stimulation of the whole hand simultaneously with a specific glove to maximize the effect of coactivation (Christova et al, 2011;Golaszewski et al, 1999;Golaszewski et al, 2004;Golaszewski et al, 2010;Golaszewski et al, 2012). Few studies also stimulated other body parts, such as the palm or foot (Christova, Rafolt, Mayr, Wilfling, & Gallasch, 2010;Christova et al, 2012;Peurala et al, 2002).…”

Section: Different Stimulation Protocolsmentioning

confidence: 99%

“…It thus allows for a systematic investigation on perceptual learning processes (Fraser et al, 2002), and also for practical applications. For example, rTS might help to increase tactile abilities in individuals with a high need for these, such as artists and fine mechanics (Ragert et al, 2004;Reuter, Voelcker-Rehage, Solveig, & Godde, unpublished), or with sensory impairments due to age (Dinse et al, 2006;Kalisch, Tegenthoff, & Dinse, 2008;Kalisch, Tegenthoff, & Dinse, 2010;Voelcker-Rehage & Godde, 2010) or stroke (K. Johansson, Lindgren, Widner, Wiklund, & Johansson, 1993;Sullivan & Hedman, 2008).…”

Section: Introduction-what Is Repetitive Tactile Stimulation and Whermentioning

confidence: 99%

See 2 more Smart Citations

Tactile stimulation interventions: Influence of stimulation parameters on sensorimotor behavior and neurophysiological correlates in healthy and clinical samples

Lesemann

Reuter

Godde

2015

Neuroscience & Biobehavioral Reviews

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High frequency somatosensory stimulation in dystonia: Evidence fordefective inhibitory plasticity

et al. 2018

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Background Apart from motor symptoms, multiple deficits of sensory processing have been demonstrated in dystonia. The most consistent behavioural measure of this is abnormal somatosensory temporal discrimination threshold, which has recently been associated with physiological measures of reduced inhibition within the primary somatosensory area. High‐frequency repetitive sensory stimulation is a patterned electric stimulation applied to the skin through surface electrodes that has been recently reported to shorten somatosensory temporal discrimination in healthy subjects and to increase the resting level of excitability in several different types of inhibitory interaction in the somatosensory and even motor areas. Objectives We tested whether high‐frequency repetitive sensory stimulation could augment cortical inhibition and, in turn, ameliorate somatosensory temporal discrimination in cervical dystonia. Methods Somatosensory temporal discrimination and a number of electrophysiological measures of sensorimotor inhibition and facilitation were measured before and after 45 minutes of high‐frequency repetitive sensory stimulation. Results As compared with a group of healthy volunteers of similar age, in whom high‐frequency repetitive sensory stimulation increased inhibition and shortened somatosensory temporal discrimination, patients with cervical dystonia showed a consistent, paradoxical response: they had reduced suppression of paired‐pulse somatosensory evoked potentials, as well as reduced high‐frequency oscillations, lateral inhibition, and short interval intracortical inhibition. Somatosensory temporal discrimination deteriorated after the stimulation protocol, and correlated with reduced measures of inhibition within the primary somatosensory cortex. Conclusions We suggest that patients with dystonia have abnormal homeostatic inhibitory plasticity within the sensorimotor cortex and that this is responsible for their paradoxical response to high‐frequency repetitive sensory stimulation. © 2018 International Parkinson and Movement Disorder Society

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Tactile coactivation resets age‐related decline of human tactile discrimination

Cited by 119 publications

References 36 publications

Increased Excitability of Somatosensory Cortex in Aged Humans is Associated with Impaired Tactile Acuity

Increased Excitability of Somatosensory Cortex in Aged Humans is Associated with Impaired Tactile Acuity

Tactile stimulation interventions: Influence of stimulation parameters on sensorimotor behavior and neurophysiological correlates in healthy and clinical samples

High frequency somatosensory stimulation in dystonia: Evidence fordefective inhibitory plasticity

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