Tactics of Biocenosis-Saving Therapy by Use Antibiotics in Children With Acute Intestinal Infections

Мазанкова, Л. Н.; Корсунский, А. А.; Продеус, А.П.; Ардатская, М. Д.; Перловская, С. Г.

doi:10.22627/2072-8107-2017-16-3-41-49

Cited by 6 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…По результатам исследований [8,9,10] комбинация антибактериальных препаратов с пробиотиками, энтеросорбентами, способствует сокращению продолжительности основных симптомов ОКИ у детей (лихорадки, диареи и др.). В отличие от пробиотиков, обладающих антагонистическим действием в отношении к патогенной флоре, бактериофаг, попадая в очаг воспаления и адсорбируясь на бактериальной клетке приводит к ее гибели, способствует активации фагоцитоза и нейтрофилов, что препятствует прогрессированию воспалительного процесса [11,12,13].…”

unclassified

Results of treatment of primary staphylococcal enterocolitis in infants with the use of antibacterial drugs and their combination with bacteriophages: a prospective study

Кимирилова

Харченко

2021

Det. infekc.

View full text Add to dashboard Cite

In infectious pathology in infants, staphylococcal infection occupies a leading place, is characterized by the rapid development of intoxication, a purulent-destructive process with the possibility of generalization of infection, affecting the course and outcome of the disease.The aim of the study was to study the results of treatment of primary staphylococcal enterocolitis, in infants, with the use of antibacterial drugs and their combination with bacteriophages.Research methods. The frequency of elimination of staphylococcus, the duration of the main symptoms (fever, diarrhea, toxicosis with exicosis) as a result of treatment of primary staphylococcal enterocolitis (confirmed by laboratory) were analyzed in children aged from 1 to 12 months who received inpatient antibacterial drugs (nifuroxazide, azithromycin) or their combination with bacteriophages (staphylococcal, pyobacteriophage). The data accounting period is from January 2017 to December 2020.The results of the study. The results of treatment of staphylococcal enterocolitis were studied in 4 groups: monotherapy with nifuroxazide (n = 39) or azithromycin (n = 40), a combination of nifroxazide+staphylococcal bacteriophage (n = 41) or azithromycin + piobacteriphage (n = 38). The groups were comparable by gender, age, and clinical manifestations of the disease. Elimination of staphylococcus on the 10th—12th day. treatment with monotherapy with antibacterial drugs was achieved in 31—35%, with their combination with bacteriophages — in 51—64% of patients in each combination (df = 3, p < 0.05). Against the background of combined therapy, the symptoms of the disease (diarrhea, vomiting) were stopped 1.2 times faster; the number of patients with lactase deficiency and intestinal dysbiosis decreased by 1.7—2 times, with monotherapy with antibacterial drugs-by 1.3—1.4 times (df = 3, p < 0.05).Conclusion. Treatment of primary staphylococcal enterocolitis in children, including antibacterial drugs and bacteriophages, is more effective than monotherapy with antibacterial drugs.

show abstract

unclassified

Results of treatment of primary staphylococcal enterocolitis in infants with the use of antibacterial drugs and their combination with bacteriophages: a prospective study

Кимирилова

Харченко

2021

Det. infekc.

View full text Add to dashboard Cite

show abstract

“…Же-латина таннат действует местно на стенку кишечника, формируя протеиновую пленку, и защищая слизистую оболочку от воздействия веществ, ответственных за ки-шечную токсемию. Танины известны своими вяжущими свойствами, обеспечивающими осаждение ответствен-ных за местное воспаление провоспалительных мукопро-теинов в кишечной слизи и выведение этих мукопротеи-нов с калом [9][10][11][12]. Предполагается, что желатина тан-нат также обладает антибактериальными и антиоксидант-ными свойствами.…”

unclassified

Effectiveness of Gelatin Tannate in Acute Infectious Diarrhea in Children

Бехтерева¹,

Комарова²,

Усков³

et al. 2017

Det. infekc.

View full text Add to dashboard Cite

The efficacy and safety of the cytomucoprotector gelatin tannate in the treatment of acute gastroenteritis in children

et al. 2021

View full text Add to dashboard Cite

Introduction. Acute gastroenteritis (AGE) is one of the leading causes of pediatric morbidity and mortality. The use of cytomuco-protectors that stabilize the intestinal barrier can increase the effectiveness of treatment.The aim is to determine the gelatin tannate (GT) clinical efficacy, safety and antiviral activity in AGE in children admitted to the hospital.Materials and methods. An open, prospective, randomized study included 52 children <7 years of age with AGE. The intervention group (n = 28) received GT, which was administered orally at 250 mg to children <3 years of age and 500 mg to children £ 3 years of age 4 times a day for 7 days. The severity of AGE (Vizikari scale: 10-14 points and CDC: 1-5 points) in parallel groups was significant. Standard treatment included rehydration and probiotic B. bifidum 1 (15 * 108 CFU / day in three divided doses). Antibiotic therapy (ABT) was received by 50% of children from each group. Fecal samples at screening and on the 7th day of treatment were examined in Real-time PCR with the determination of nucleic acids of rotaviruses A, noro-, adeno-, astro- and enteroviruses. The viral etiology of AGE was confirmed in 53.8%, salmonellosis - in 3.8% and campylobacteriosis - in 1.9% of patients.Results. GT reduced the risk of diarrhea on day 5 by 32% [95% confidence interval 14-50%] OR 0.25 [0.11-0.25] and by 14% [4-24%] by day 7. In the GT group, on day 7 of treatment, all patients had normal stool consistency. GT reduced the time for stool normalization by 1.3 days [0.2-2.3]. A more significant effect was obtained in patients with risk factors for insufficient treatment efficacy and in patients with inflammatory AGE requiring ABT. In those who received GT, a decrease in the concentration of viruses in feces was found, in the control - no statistical differences. The recurrence of AGE symptoms during hospital treatment was recorded with a frequency of 3.6% and 16.7%, respectively (p = 0.111).Conclusions. GT significantly reduced the risks of incomplete therapy effect by day 7 of treatment and the average positiveness of stool normalization. Trends in the antiviral action of GT and its positive effect on the incidence of nosocomial viruses.

show abstract

Tactics of Biocenosis-Saving Therapy by Use Antibiotics in Children With Acute Intestinal Infections

Cited by 6 publications

References 11 publications

Results of treatment of primary staphylococcal enterocolitis in infants with the use of antibacterial drugs and their combination with bacteriophages: a prospective study

Results of treatment of primary staphylococcal enterocolitis in infants with the use of antibacterial drugs and their combination with bacteriophages: a prospective study

Effectiveness of Gelatin Tannate in Acute Infectious Diarrhea in Children

The efficacy and safety of the cytomucoprotector gelatin tannate in the treatment of acute gastroenteritis in children

Contact Info

Product

Resources

About