Tactics of antihypertensive therapy in patients with hypertonic crisis complicated with hemorrhagic stroke

Сторожаков, Г. И.; Гендлин, Г. Е.; Анисимова, А. В.; Мелехов, А. В.; Ostrovskaya, Yu. I.

doi:10.17116/jnevro2015115312-19

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…В настоящее время сердечно-сосудистым заболеваниям (ССЗ) отводят лидирующее место в структуре утрaты трудоспособности и смертности во всем мире [1,2]. В структуре сердечно-сосудистой патологии сердечные аритмии занимают лидирующие позиции и представляют прямую угрозу жизни пациентов [3]. Фибрилляция предсердий (ФП) остается самой распространенной аритмией, ответственной за значительную долю инвалидизации и смертности населения [4,5].…”

Section: Introductionunclassified

“…Независимо от наличия известных факторов риска смертность у больных с ФП удваивается [10], к тому же возникновение ФП приводит к изменениям внутрисердечной гемодинамики и сопряжено с развитием тяжелых осложнений: хронической сердечной недостаточности (ХСН) и тромбоэмболических осложнений. Отмечается увеличение с возрастом доли инсультов, которые возникают на фоне ФП: в возрасте 50-59 лет -6,5%, у 80-89-лет-них -до 30,7% [3,9]. Инсульт при ФП протекает более тяжело, приводит к постоянной инвалидности и смерти [1].…”

Section: Introductionunclassified

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Problem of prescribing anticoagulant therapy in patients with atrial fibrillation on the regional level

2020

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Introduction. Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, with heart rhythm disorders accounting for a significant proportion of them. Atrial fibrillation (AF) is an arrhythmia that poses a risk of thromboembolic complications and is difficult to treat with ongoing preventive anticoagulant therapy. Aim of the study. To analyze the prescription of anticoagulant therapy to patients with AF on the regional level. Methods and results. The study included 72 patients with the nonvalvular form of AF (from 41 to 82 years old) of the Department of Rhythm and Conductivity Abnormalities of the State Budgetary Institution of the Republic of Mordovia RCH № 4 for 2019. Three groups were singled out depending on the AF form: the first one – patients with the constant form (n = 22), the second one (n = 24) – with the persistent form, the third one (n = 24) – with the paroxysmal form. The risk of thromboembolic complications was assessed using the CHA2DS2-VASc scale and hemorrhagic complications using the HAS-BLED scale. All patients had a high risk of thromboembolism (index above 2 points), which reflects multiple risk factors and indicates the need for oral anticoagulants (OAC). According to HAS-BLED scale calculations, the risk of haemorrhagic complications was low in most patients (2 or less points) – there was no significant increase in the risk of bleeding, but careful monitoring is required. Analysis of the results revealed that only 54% of patients took OAC, despite the fact that all patients were shown anticoagulant therapy. When analyzing the cases of patients who did not take anticoagulants, it was found that 23% of patients, despite the doctor’s recommendations, refused to take the drugs, 47% of patients justified the inability to control IHR and 30% were unable to purchase expensive new OAC. Conclusion. Despite the recommendations for the management of patients with atrial fibrillation, only 54% were prescribed oral anticoagulants.

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Problem of prescribing anticoagulant therapy in patients with atrial fibrillation on the regional level

2020

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The Model for Clinical, Laboratory, and Genetic Prediction of Recurrent Ischemic Stroke against the Background of Laboratory Aspirin Resistance using Machine Learning

Anastasia V,

Sergey S,

Anastasia S

et al. 2024

IgMin Res

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The aim of the study was to determine the incidence of laboratory aspirin resistance; and to study the associations of genetic markers and clinical and laboratory parameters (including parameters of the platelet hemostasis) in patients with non-cardioembolic ischemic stroke using machine learning methods to assess the prognosis of recurrent ischemic strokes. Clinical and laboratory data (including induced platelet aggregation) were analyzed from 296 patients with ischemic stroke who were treated in the stroke center of City Clinical Hospital No. 1 named after. N.I. Pirogov. The frequencies of polymorphic variants of the ITGB3, GPIba, TBXA2R, ITGA2, PLA2G7, HMOX1, PTGS1, PTGS2, ADRA2A, ABCB1, PEAR1 genes and intergenic region 9p21.3) in patients with non-cardioembolic ischemic stroke, which were identified using hydrogel biochip technology, were determined. Using the developed machine learning model, additional clinical and genetic factors influencing the development of laboratory aspirin resistance and recurrent ischemic stroke were studied. In the future, the identified factors can be used for differentiated prevention of recurrent ischemic strokes.

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Tactics of antihypertensive therapy in patients with hypertonic crisis complicated with hemorrhagic stroke

Cited by 2 publications

References 3 publications

Problem of prescribing anticoagulant therapy in patients with atrial fibrillation on the regional level

Problem of prescribing anticoagulant therapy in patients with atrial fibrillation on the regional level

The Model for Clinical, Laboratory, and Genetic Prediction of Recurrent Ischemic Stroke against the Background of Laboratory Aspirin Resistance using Machine Learning

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