Tactics for modeling multiple salivary analyte data in relation to behavior problems: Additive, ratio, and interaction effects

Chen, Frances R.; Raine, Adrian; Granger, Douglas A.

doi:10.1016/j.psyneuen.2014.09.027

Cited by 38 publications

(28 citation statements)

References 57 publications

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“…An interactive model assumes that two biomarkers work in coordination and can confirm differing relationships between one biomarker and a behavior depending on the pattern of release of the other biomarker. In their study utilizing this model, Chen et al (2015) found that cortisol was negatively associated with externalizing problems only when sAA was at low levels. In turn, the effect of cortisol on behavioral outcomes was conditional on sAA concentrations, which would not have been obvious if cortisol and sAA had been analyzed separately.…”

Section: Introductionmentioning

confidence: 98%

“…Vries-Bouw and colleagues (2012) used regression analyses to show cortisol and sAA reactivity had a combined impact on negative behavior in adolescents – low reactivity of both parameters was related to higher levels of disruptive behavior. Chen et al (2015) argue that an interactive model is better than a simple additive model when examining the effects of cortisol and sAA secretion in behavioral outcomes. An interactive model assumes that two biomarkers work in coordination and can confirm differing relationships between one biomarker and a behavior depending on the pattern of release of the other biomarker.…”

Section: Introductionmentioning

confidence: 99%

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Cortisol and salivary alpha-amylase trajectories following a group social-evaluative stressor with adolescents

Katz

Peckins

2017

Psychoneuroendocrinology

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Intraindividual variability in stress responsivity and the interrelationship of multiple neuroendocrine systems make a multisystem analytic approach to examining the human stress response challenging. The present study makes use of an efficient social-evaluative stress paradigm –the Group Public Speaking Task for Adolescents (GPST-A) – to examine the hypothalamic-pituitary-adrenocortical (HPA)-axis and Autonomic Nervous System (ANS) reactivity profiles of 54 adolescents with salivary cortisol and salivary alpha-amylase (sAA). First, we account for individuals’ time latency of hormone concentrations between individuals. Second, we use a two-piece multilevel growth curve model with landmark registration to examine the reactivity and recovery periods of the stress response separately. This analytic approach increases the models’ sensitivity to detecting trajectory differences in the reactivity and recovery phases of the stress response and allows for interindividual variation in the timing of participants’ peak response following a social-evaluative stressor. The GPST-A evoked typical cortisol and sAA responses in both males and females. Males’ cortisol concentrations were significantly higher than females’ during each phase of the response. We found no gender difference in the sAA response. However, the rate of increase in sAA as well as overall sAA secretion across the study were associated with steeper rates of cortisol reactivity and recovery. This study demonstrates a way to model the response trajectories of salivary biomarkers of the HPA-axis and ANS when taking a multisystem approach to neuroendocrine research that enables researchers to make conclusions about the reactivity and recovery phases of the HPA-axis and ANS responses. As the study of the human stress response progresses toward a multisystem analytic approach, it is critical that individual variability in peak latency be taken into consideration and that accurate modeling techniques capture individual variability in the stress response so that accurate conclusions can be made about separate phases of the response.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Cortisol and salivary alpha-amylase trajectories following a group social-evaluative stressor with adolescents

Katz

Peckins

2017

Psychoneuroendocrinology

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“…Specifically, while cortisol has a catabolic function, DHEA(S) seems to have an anabolic, regenerative, and neuroprotective function in the brain and cardiovascular system (Maninger et al, 2009), which may be mediated through effects on brain derived neurotrophic factor (BDNF) and gamma-aminobutyric-acid (GABA)-metabolism (Genud et al, 2009;Sakr et al, 2014). Consequently, the cortisol/DHEA(S)-ratio is proposed to represent a balance between catabolic and anabolic activity (Chen et al, 2015;Lennartsson et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?

Mocking

Pellikaan

Lok

et al. 2015

Psychoneuroendocrinology

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“…However, with respect to depressive symptoms specifically, the literature directly linking salivary cortisol and depression (as a main, direct effect) has been somewhat inconsistent. One possibility raised by Granger and Kivlighan (2003) and others (Chen et al, 2015; Granger et al, 2007) is that across study inconsistency in findings linking cortisol to behavior may be at least in part due to a narrow operationalization of activity of the HPA axis. In response to adverse circumstances, the HPA axis secretes multiple products (e.g., dehydroepiandrosterone, epinephrine, norepinephrine), not just cortisol.…”

Section: Depression Symptoms Marital Relationships and Hpa Axis mentioning

confidence: 99%

“…Most studies exploring combined effects have focused on the ratio of cortisol to DHEA(S). However, ratios are subject to statistical and interpretational problems (Chen et al, 2015; Sollberger and Ehlert, 2015). A more informative method for uncovering the combined roles of cortisol and DHEA(S) is to test for statistical interactions between cortisol and DHEA(S).…”

Section: Depression Symptoms Marital Relationships and Hpa Axis mentioning

confidence: 99%

Concurrent and prospective associations between HPA axis activity and depression symptoms in newlywed women

Pietromonaco

DeBuse

et al. 2016

Psychoneuroendocrinology

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We investigated the extent to which individual differences in activity of the hypothalamic pituitary adrenal axis (HPA) are associated with depressive symptoms among newlywed couples. Participants were 218 couples (M age 28.4 years; 94% White) who provided 5 saliva samples (later assayed for cortisol and DHEA-S) before and after participation in a discussion of a major area of disagreement in their relationship. Depressive symptoms were assessed initially, and approximately 19- and 37-months later. Results revealed an interactive effect suggesting that concordant levels of cortisol and DHEA-S (either both high or both low) were concurrently and prospectively associated with higher depression scores. Interestingly, this interactive effect was observed for wives only – not for husbands. These observations underscore contemporary theoretical assumptions that the expression of the association between HPA activity and depression is dependent on factors related to the interaction between characteristics of the person and features of the social environment, and moderated by co-occurring variation in endocrine milieu.

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Tactics for modeling multiple salivary analyte data in relation to behavior problems: Additive, ratio, and interaction effects

Cited by 38 publications

References 57 publications

Cortisol and salivary alpha-amylase trajectories following a group social-evaluative stressor with adolescents

Cortisol and salivary alpha-amylase trajectories following a group social-evaluative stressor with adolescents

DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?

Concurrent and prospective associations between HPA axis activity and depression symptoms in newlywed women

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