Tacrolimus ointment in onychodystrophy associated with eczema

Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open‐label study

“…This rapidity of action is remarkable for the fact that other topical therapies for nail psoriasis have been Tacrolimus 0.1% ointment in nail psoriasis reported to give clinical responses similar to that which we observed after a mean of 5-6 months of treatment. 2 Previous experiences with tacrolimus ointment in nail dystrophies [8][9][10][11][12] also report effective results after similar durations of treatment.…”

“…On the basis of these observations, we speculated the efficacy of topical tacrolimus in nail psoriasis, which often represents an isolated clinical presentation of the disease and is very difficult to treat. Moreover, previous studies had already shown that tacrolimus ointment may penetrate the periungueal skin enough to improve a nail dystrophy 8–12 . In fact, it was successfully used to treat nail dystrophy associated with chronic paronychia, 8 eczema 9 and lichen planus 10,11 and in a case of median canaliform nail dystrophy 12 …”

“…Moreover, previous studies had already shown that tacrolimus ointment may penetrate the periungueal skin enough to improve a nail dystrophy. [8][9][10][11][12] In fact, it was successfully used to treat nail dystrophy associated with chronic paronychia, 8 eczema 9 and lichen planus 10,11 and in a case of median canaliform nail dystrophy. 12 Our study showed the efficacy and safety of tacrolimus ointment in nail psoriasis, using as control a hand of the same patient, left untreated.…”

Successful Treatment of Nail Lichen Planus with Topical Tacrolimus

“…Recent studies demonstrated that nail dystrophy associated with chronic paronychia (14) and eczema (15) improved with topical tacrolimus, which suggests that topical tacrolimus could penetrate the periungual skin enough to improve the nail dystrophy. In addition, the remarkable thinning ofthe nails and onyehorrhexis seen in most ofour NLP cases make it possible that the tacrolimus ointment penetrated the damaged nail plates.…”

Treatment of median canaliform nail dystrophy with topical 0.1% tacrolimus ointment

“…Recently, the favorable outcomes of off‐label uses have been reported in a variety of other dermatoses including psoriasis, seborrheic dermatitis, contact dermatitis and vitiligo 9 . In addition, a case of non‐specific nail dystrophy with eczema treated with topical tacrolimus was reported 10 . The action mechanism of tacrolimus ointment in MCND is difficult to clarify; however, because inflammatory process has been suggested as an important contributing factor in the pathogenesis of MCND, the anti‐inflammatory effects of tacrolimus seem to fit into the picture.…”