Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas

Freeman, Amy Krupnick; Linowski, Gregory J.; Brady, Christopher J.; Lind, Leah; VanVeldhuisen, Paul; Singer, Giselle; Lebwohl, Mark

doi:10.1067/mjd.2003.169

Cited by 115 publications

(92 citation statements)

References 19 publications

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“…Several reports demonstrated that topical application of FK506 ointment was only effective under occlusion or to some specific regions of the body where the skin was thinner and more permeable, such as the face and intertriginous areas. [23][24][25][26][27] The poor efficacy of FK506 for topical therapy was attributed to its high hydrophobicity and high molecular weight (822.05 Da), which prevent it from penetrating into and through the skin. In our previous study, 28 we have formulated a hybrid nanoparticle system for FK506 percutaneous delivery.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Wan

Pan

Long

et al. 2017

IJN

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The hybrid system based on nanoparticles (NPs) self-assembled by the conjugations of hyaluronic acid with cholesterol (HA–Chol NPs) combined with nicotinamide (NIC) for tacrolimus (FK506), ie, FK506 NPs–NIC, has been confirmed to exhibit a significant synergistic effect on FK506 permeation through and into intact skin; thus, it may be a promising approach for FK506 to effectively treat skin diseases. The aim of this study was to evaluate its potential for the treatment of psoriasis. In vitro permeation through the psoriatic skin was carried out, and the results revealed that the combination of NPs with NIC exhibited a significant synergistic effect on FK506 deposition within the psoriatic skin (3.40±0.67 μg/cm 2 ) and penetration through the psoriatic skin (30.86±9.66 μg/cm 2 ). The antipsoriatic activity of FK506 NPs–NIC was evaluated through the treatment for imiquimod (IMQ)-induced psoriasis. The psoriasis area and severity index (PASI) score demonstrated that FK506 HA–Chol NPs–NIC exerted the effect on ameliorating the skin lesions comparable to clobetasol propionate (a positive drug for psoriasis) and superior to commercial FK506 ointment (Protopic ® ), and the histological study showed that it presented a synergistic effect on antipsoriasis after FK506 incorporation into NPs combined with NIC hydrotropic system, which might ultimately increase the therapeutic effect and minimize the systemic side effects by reducing the overall dose of FK506. RAW 264.7 cell uptake presented the enhancement of drugs delivered into cells by HA–Chol NPs–NIC. The antiproliferative activity on HaCaT cells identified that FK506 HA–Chol NPs–NIC exhibited significant inhibiting effects on HaCaT proliferation. The results support that the combination of HA–Chol NPs with NIC is a promising approach for FK506 for the treatment of psoriasis.

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Section: Introductionmentioning

confidence: 99%

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Wan

Pan

Long

et al. 2017

IJN

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“…A total of 81 percent of patients experienced complete clearance at day 57 (end of treatment). Only 2 patients reported adverse events, which were limited to itching and the feeling of warmth at the application site (Freeman et al, 2003).…”

Section: Tacrolimusmentioning

confidence: 99%

“…The safety and efficacy of tacrolimus (0.1 %) ointment for the treatment of psoriasis on the face, intertriginous areas, or both were evaluated in an open-label, clinical trial of 21 patients with psoriasis (Freeman et al, 2003). A total of 81 percent of patients experienced complete clearance at day 57 (end of treatment).…”

Section: Tacrolimusmentioning

confidence: 99%

Topical Therapies for Psoriasis

Mitra¹,

Atillasoy²

2012

Psoriasis

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“…On the other hand, topical tacrolimus is effective for not only mild but also severe facial plaque psoriasis, although in a single case report [33]. Additionally, tacrolimus is tolerably effective for intertriginous and genital psoriasis [29,[34][35][36]. Tacrolimus was significantly more effective for facial and genitofemoral areas of psoriasis, compared with calcitriol ointment [37].…”

Section: Topical Tacrolimus Therapy For Psoriasismentioning

confidence: 99%

“…Since then, several reports demonstrated that topical tacrolimus is highly effective for facial and intertriginous psoriasis [29][30][31][32]. In an open-label trial, 0.1% tacrolimus ointment was applied twice daily for 8 weeks for the facial or intertriginous areas in 21 patients with psoriasis [29].…”

Section: Topical Tacrolimus Therapy For Psoriasismentioning

confidence: 99%

Topical Tacrolimus for Psoriasis

Yamamoto¹

2009

TOALLJ

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Tacrolimus ointment is an agent approved for the treatment of atopic dermatitis; however, tacrolimus has been expected also as one of the promising therapeutic strategies for other T-cell mediated inflammatory skin disorders. Recent progress have demonstrated that topical tacrolimus shows beneficial effects for psoriasis depending on sites. In particular, facial, intertriginous, and genital psoriasis respond to topical tacrolimus dramatically in a short period. Further, topical tacrolimus is tolerable also for child psoriasis. Because topical tacrolimus does not induce either skin atrophy or telangiectasia different from corticosteroids, it is recommended to be a first choice. The most proper way of topical tacrolimus therapy at present is to use this ointment intermittently after the remission was once obtained, paying attention to its adverse effects.

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Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas

Cited by 115 publications

References 19 publications

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

Topical Therapies for Psoriasis

Topical Tacrolimus for Psoriasis

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