Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats

Karasová, Jana Žďárová; Soukup, Ondřej; Korábečný, Jan; Hroch, Miloš; Krejciova, Marketa; Hrabinová, Martina; Mišík, Ján; Novotný, Ladislav; Hepnarová, Vendula; Kuča, Kamil

doi:10.1080/01480545.2019.1566350

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Cited by 7 publications

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Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

Prchalova,

Andrys,

Pejchal

et al. 2024

Arch Toxicol

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Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

Prchalova,

Andrys,

Pejchal

et al. 2024

Arch Toxicol

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Controlled Release 7-Methoxytacrine-Polycaprolactone Nanocapsules Drug-Delivery System for Alzheimer's Disease Treatment: Synthesis and Physico-Chemical Characterization

et al. 2021

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Alzheimer's disease is the most prevalent cause of dementia in aging people. 7-Methoxytacrine (7-MEOTA) is one of the approved drugs for the treatment of this disease. In the current study, a 7-MEOTA delivery system has been prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL) and its physico-chemical properties were investigated as well. The drug amount loaded in nanocapsules has been estimated 65%. The average particle size of the 7-MEOTA@PCL nanocapsules was around 237 nm with polydispersity index of 0.31 and negative surface charge (-21.2 mV). The prepared nanoparticles are stable upon 40 days storage at 25 °C, without any decomposition. The morphological analysis of the 7-MEOTA@PCL nanoparticles indicated that the nanoparticles are spherical, and free of any aggregation. In vitro release experiments revealed controlled release of the 7-MEOTA from the polycaprolactone nanocapsules. Application of the Korsmeyer-Peppas model to the release kinetics data showed that the release of the drug was by diffusion Fick's law.

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Tacrine

Khaleseh¹,

Haghi‐Aminjan²,

Samadi³

2024

Encyclopedia of Toxicology

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Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats

Cited by 7 publications

References 46 publications

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents

Controlled Release 7-Methoxytacrine-Polycaprolactone Nanocapsules Drug-Delivery System for Alzheimer's Disease Treatment: Synthesis and Physico-Chemical Characterization

Tacrine

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