Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy

Lodewijk, Iris; Nunes, Sandra P.; Henrique, Rui; Jerónimo, Carmen; Dueñas, Marta; Paramio, Jesús M.

doi:10.1186/s13148-021-01046-0

Cited by 45 publications

(32 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The epigenetic machinery plays a central role in generating an immunosuppressive environment for cancer growth. For this reason, epigenetic alterations affecting immune cell function in the tumor microenvironment represent a growing area of investigation [43].…”

Section: Discussionmentioning

confidence: 99%

Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development

Camacho

Ramírez²,

Pérez-Alonso

et al. 2021

IJMS

View full text Add to dashboard Cite

Breast cancer continues to be one of the main causes of morbidity and mortality globally and was the leading cause of cancer death in women in Spain in 2020. Early diagnosis is one of the most effective methods to lower the incidence and mortality rates of breast cancer. The human metalloproteinases (MMP) mainly function as proteolytic enzymes degrading the extracellular matrix and plays important roles in most steps of breast tumorigenesis. This retrospective cohort study shows the immunohistochemical expression levels of MMP-1, MMP-2, MMP-3, and MMP-9 in 154 women with breast cancer and 42 women without tumor disease. The samples of breast tissue are assessed using several tissue matrices (TMA). The percentages of staining (≤50%–>50%) and intensity levels of staining (weak, moderate, or intense) are considered. The immunohistochemical expression of the MMP-1-intensity (p = 0.043) and MMP-3 percentage (p = 0.018) and intensity, (p = 0.025) present statistically significant associations with the variable group (control–case); therefore, expression in the tumor tissue samples of these MMPs may be related to the development of breast cancer. The relationships between these MMPs and some clinicopathological factors in breast cancer are also evaluated but no correlation is found. These results suggest the use of MMP-1 and MMP-3 as potential biomarkers of breast cancer diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development

Camacho

Ramírez²,

Pérez-Alonso

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Similarly, ECM stiffness regulates epidermal cell proliferation, migration, and differentiation based on the Rho/ROCK pathway through integrin stimulation [ 65 ]. Additionally, the mechanical properties of cell, including cell stiffness, could become potential therapeutic target for cancer chemotherapy and immune therapy [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanical Cues Regulate Histone Modifications and Cell Behavior

Zhou

Wang

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

Change of biophysical factors in tissue microenvironment is an important step in a chronic disease development process. A mechanical and biochemical factor from cell living microniche can regulate cell epigenetic decoration and, therefore, further induce change of gene expression. In this review, we will emphasize the mechanism that biophysical microenvironment manipulates cell behavior including gene expression and protein decoration, through modifying histone amino acid residue modification. The influence given by different mechanical forces, including mechanical stretch, substrate surface stiffness, and shear stress, on cell fate and behavior during chronic disease development including tumorigenesis will also be teased out. Overall, the recent work summarized in this review culminates on the hypothesis that a mechanical factor stimulates the modification on histone which could facilitate disease detection and potential therapeutic target.

show abstract

“…The critical components involved in dysregulated epigenetic signaling network might be shared among different types of cells, but the biological consequences are highly cell-type specific ( 57 ). The overall epigenetic landscape of macrophages and other tumor-infiltration immune cells has been reviewed by several scientists recently ( 58 – 60 ). In this review, we would mainly discuss experimental studies as well as the potential applications regarding the epigenetic modifications associated with TAMs, which might inspire more basic and translational researches to investigate the epigenetic modifications of macrophages in malignant transformation and cancer management.…”

Section: Epigenetic Modifications Associated With Macrophage Education By the Tmementioning

confidence: 99%

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

2022

View full text Add to dashboard Cite

Tumorigenesis is frequently accompanied by chronic inflammation, and the tumor microenvironment (TME) can be considered an ecosystem that consists of tumor cells, endotheliocytes, fibroblasts, immune cells and acellular components such as extracellular matrix. For tumor cells, their survival advantages are dependent on both genetic and epigenetic alterations, while other cells mainly present epigenetic modifications. Macrophages are the most plastic type of immune cells and undergo diverse epigenetic alterations in the TME. Some of these epigenetic modifications mitigate against cancer progression, and others accelerate this process. Due to the complex roles of macrophages in the TME, it is urgent to understand their epigenetic modifications associated with the TME. Here, we mainly summarize recent findings on TME-associated epigenetic alterations of tumor-associated macrophages (TAMs), including DNA methylation, posttranslational modifications of histone proteins, chromatin remodeling, and noncoding RNA-mediated epigenetic regulation. At the end of this review, we also discuss the translational potential of these epigenetic modifications for developing novel cancer therapies targeting TAMs.

show abstract

Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy

Cited by 45 publications

References 223 publications

Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development

Metalloproteinases 1 and 3 as Potential Biomarkers in Breast Cancer Development

Mechanical Cues Regulate Histone Modifications and Cell Behavior

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

Contact Info

Product

Resources

About