Tackling the biophysical properties of sphingolipids to decipher their biological roles

Carreira, Ana C.; Ventura, Ana E.; Varela, Ana R.P.; Silva, Liana C.

doi:10.1515/hsz-2014-0283

Cited by 20 publications

(16 citation statements)

References 70 publications

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“…Although the precise nature and function of these domains, which also include rafts, are still not clear, they could have important roles in regulating the function of membrane receptors. Thus, ceramides could influence cell signalling by contributing to (and potentially promoting) the formation of membrane domains 59 .…”

Section: Cellular Functionsmentioning

confidence: 99%

Sphingolipids and their metabolism in physiology and disease

Hannun

Obeid

2017

Nat Rev Mol Cell Biol

1,287

1,396

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Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome. These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingolipid metabolism to key human diseases. Nevertheless, the fairly nascent field of bioactive sphingolipids still faces challenges in its biochemical and molecular underpinnings, including defining the molecular mechanisms of pathway and enzyme regulation, the study of lipid-protein interactions and the development of cellular probes, suitable biomarkers and therapeutic approaches.

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Section: Cellular Functionsmentioning

confidence: 99%

Sphingolipids and their metabolism in physiology and disease

Hannun

Obeid

2017

Nat Rev Mol Cell Biol

1,287

1,396

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“…In fact, sphingolipids are ubiquitous components of eukaryotic cell membranes known to be involved in a variety of cellular processes including proliferation, growth, differentiation, apoptosis and membrane structure (Futerman and Hannun, 2004; Lahiri and Futerman, 2007; Carreira et al, 2015). Dysregulation of their metabolism is evident in various pathological conditions including cancer (Gulbins and Petrache, 2013; Don et al, 2014; Giussani et al, 2014; Roh et al, 2016).…”

Section: Cisplatin-membrane Interactionsmentioning

confidence: 99%

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

et al. 2019

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Cisplatin and other platinum(II) analogs are widely used in clinical practice as anti-cancer drugs for a wide range of tumors. The primary mechanism by which they exert their action is through the formation of adducts with genomic DNA. However, multiple cellular targets by platinum(II) complexes have been described. In particular, the early events occurring at the plasma membrane (PM), i.e., platinum-membrane interactions seem to be involved in the uptake, cytotoxicity and cell-resistance to cisplatin. In fact, PM influences signaling events, and cisplatin-induced changes on membrane organization and fluidity were shown to activate apoptotic pathways. This review critically discusses the sequence of events caused by lipid membrane-platinum interactions, with emphasis on the mechanisms that lead to changes in the biophysical properties of the membranes (e.g., fluidity and permeability), and how these correlate with sensitivity and resistance phenotypes of cells to platinum(II) complexes.

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“…Sphingolipids (SLs) comprise one of the major group of lipids in the plasma membrane (PM) of eukaryotes, and their spatial arrangement in the PM is essential for several vital cellular functions, such as growth, survival, differentiation, senescence, inflammation, and immune and stress responses [1–5]. SLs present large structural diversity, and any alterations of SL composition can potentially exert a strong impact on several biophysical properties of membranes such as fluidity, hydration, passive permeability, lateral diffusion of components, membrane curvature and thickness [2,6–8]. These effects are considered an integral part of the mechanisms by which SLs fulfil their different biological functions.…”

Section: Figurementioning

confidence: 99%

Sphingolipid‐enriched domains in fungi

et al. 2020

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Plasma membrane carries out multiple physiological functions that require its dynamic and tightly regulated organization into specialized domains of different size, stability, and lipid/protein composition. Sphingolipids are a group of lipids in which the plasma membrane is particularly enriched, thus being crucial for its structure and function. A specific type of sphingolipid‐enriched plasma membrane domains, where ergosterol is depleted and lipids are tightly packed in a rigid gel phase, has recently been found in several fungal species, including yeasts and moulds. After presenting the main biophysical features of gel domains and the experimental method for their detection in the fungal plasma membrane, we review these sphingolipid‐enriched gel domains and illustrate their importance to both unicellular and multicellular fungi. First, the biophysical properties of the fungal sphingolipid‐enriched domains will be analysed taking into consideration the plasma membrane sphingolipidome. Next, their possible biological roles will be summarized, including their relations with plasma membrane compartments and involvement in stress responses. Moreover, since the plasma membrane is a target for several antifungal compounds, a biophysical connection between sphingolipid‐enriched domains and antifungal action will be explored.

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Tackling the biophysical properties of sphingolipids to decipher their biological roles

Cited by 20 publications

References 70 publications

Sphingolipids and their metabolism in physiology and disease

Sphingolipids and their metabolism in physiology and disease

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Sphingolipid‐enriched domains in fungi

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