Tackling Mantle Cell Lymphoma in Europe

Horgan, Denis; Walewski, Jan; Aurer, Igor; Visco, Carlo; Giné, Eva; Fetică, Bogdan; Kozaric, Marta; Silva, Maria Gomes da; Dreyling, Martin

doi:10.3390/healthcare10091682

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Marco Ladetto 2 Maurizio Martelli 3 Carlo Visco 4 Francesco Zaja 5 Emanuele Guardalben 6 Pier Luigi Zinzani…”

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“…As a result, the distribution of hub/spoke centres across the country, and the procedures for patient referral, do not usually create significant barriers to the management of patients with R/R-MCL; this contrasts with other European contexts. 4 In Italy, although patients with MCL are usually referred to specialized centres more frequently than those with other haematological conditions, they may face organisational barriers that hinder timely access to novel treatments. In this context, the panellists unanimously rated the participation of Italian patients in international clinical studies, especially early-phase trials, as 'important', and currently unsatisfactory.…”

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Unmet needs in relapsed/refractory mantle cell lymphoma after failure of covalent Bruton's tyrosine kinase inhibitors: An Italian scenario

Pinto,

Ladetto,

Martelli

et al. 2024

Hematological Oncology

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“…Marco Ladetto 2 Maurizio Martelli 3 Carlo Visco 4 Francesco Zaja 5 Emanuele Guardalben 6 Pier Luigi Zinzani…”

Section: Conflict Of Interest Statementunclassified

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confidence: 99%

Unmet needs in relapsed/refractory mantle cell lymphoma after failure of covalent Bruton's tyrosine kinase inhibitors: An Italian scenario

Pinto,

Ladetto,

Martelli

et al. 2024

Hematological Oncology

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Presence of herpesviruses, parvoviruses, and polyomaviruses in sinonasal lymphoma

Jauhiainen,

Mohanraj,

Perdomo

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose Sinonasal lymphoma (SL) is a rare lymphatic neoplasm of the nasal cavities, paranasal sinuses and nasopharynx. Whereas some risk factors for SL subtypes have been identified, their aetiology is unknown. Along with other predisposing factors, the viral association of lymphomas, such as Epstein-Barr virus (EBV) and Burkitt and Hodgkin lymphomas, is well-established. Modern molecular biology techniques have enabled the discovery of novel human viruses, exemplified by the protoparvovirus cutavirus (CuV), associated with cutaneous T-cell lymphoma. These findings, and the anatomical location of the sinonasal tract with its rich microbiome and infectious agents, justify in-depth studies among SL. Methods We analysed the presence of 20 viruses of Orthoherpesviridae, Parvoviridae, and Polyomaviridae by qPCR in 24 SL tumours. We performed RNAscope in situ hybridisation (RISH) to localize the viruses. Parvovirus-specific IgG was analysed by enzyme immunoassay and targeted next-generation sequencing (NGS) was applied to detect CuV in plasma. Results We detected viral DNA in 15/24 (63%) tumours; nine of EBV, six of human herpesvirus (HHV) -7, four each of HHV-6B and parvovirus B19, two of cytomegalovirus, and one each of CuV and Merkel-cell polyomavirus. We found tumours with up to four viruses per tumour, and localized CuV and EBV DNAs by RISH. Two of the ten plasma samples exhibited CuV IgG, and one plasma sample demonstrated CuV viremia by NGS. Conclusion Viruses were frequent findings in SL. The EBV detection rate was high in diffuse large B-cell lymphoma, and co-detections with other viruses were prevalent.

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Knowledge, skills, and confidence gaps impacting treatment decision making in relapsed/refractory chronic lymphocytic leukemia and mantle cell lymphoma: a quantitative survey study in France, Germany, and the United States

Peloquin,

Cymbalista,

Dreyling

et al. 2024

BMC Cancer

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Background With recent advancements in the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), healthcare specialists may face challenges making treatment and management decisions based on latest evidence for the optimal care of patients with these conditions. This study aimed to identify specific knowledge, skills, and confidence gaps impacting the treatment of CLL and MCL, to inform future educational activities. Methods Hematologists and hemato-oncologists (HCPs, n = 224) from France (academic settings), Germany, and the United States (academic and community settings) responded to a 15-minute quantitative needs assessment survey that measured perceived knowledge, skills, and confidence levels regarding different aspects of treatment and management of CLL and MCL patients, as well as clinical case questions. Descriptive statistics (cross tabulations) and Chi-square tests were conducted. Results Four areas of educational need were identified: (1) sub-optimal knowledge of treatment guidelines; (2) sub-optimal knowledge of molecular testing to inform CLL/MCL treatment decisions; (3) sub-optimal skills when making treatment decisions according to patient profile (co-morbidities, molecular testing results); and (4) challenges balancing the risk of toxicities with benefits of treatment. Over one-third of the respondents reported skill gaps when selecting suitable treatment options and prescribing therapies and reported a lack in confidence to initiate and manage treatment. Larger gaps in knowledge of guidelines and skills in patient assessment were identified in MCL, compared to CLL. Conclusions This study suggests the need for continuing medical education specifically to improve knowledge of treatment guidelines, and to assist clinicians in developing skills and confidence when faced with clinical decision-making scenarios of patients with specific comorbidities and/or molecular test results, for example, through case-based learning activities.

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Tackling Mantle Cell Lymphoma in Europe

Cited by 4 publications

References 55 publications

Unmet needs in relapsed/refractory mantle cell lymphoma after failure of covalent Bruton's tyrosine kinase inhibitors: An Italian scenario

Unmet needs in relapsed/refractory mantle cell lymphoma after failure of covalent Bruton's tyrosine kinase inhibitors: An Italian scenario

Presence of herpesviruses, parvoviruses, and polyomaviruses in sinonasal lymphoma

Knowledge, skills, and confidence gaps impacting treatment decision making in relapsed/refractory chronic lymphocytic leukemia and mantle cell lymphoma: a quantitative survey study in France, Germany, and the United States

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