Tackling Malaria

Dunavan, Claire Panosian

doi:10.1038/scientificamerican1205-76

Cited by 5 publications

(3 citation statements)

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“…Anopheles gambiae the most aggressive among the more than 60 mosquito species that transmit malaria to people in sub-Saharan Africa and bears partial responsibility for millions of human deaths per year (Vizioli et al, 2000;Dunavan, 2005 andLegoff et al, 2006).P. falciparum and P. vivax are the two dominant parasite species with relative frequency of 60% and 40%, respectively in Ethiopia (Gezahegn, 2004).…”

Section: Etiologymentioning

confidence: 99%

“…The sporozoite form of the parasite is inoculated into humans when bitten by an infected female Anopholes mosquito ( Figure 1). The parasites go through several host cells by breaching their plasma membrane before infecting a final hepatocyte (Dunavan, 2005). Sporozoites rapidly enter the liver cells where they multiply to form thousands of merozoites.…”

Section: Etiologymentioning

confidence: 99%

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Review on Malaria and Antimalarial Activity of Vernonia Amygdalina in Ethiopia: A Review Article

Bihonegn¹

2019

JHMN

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Malaria is a mosquito borne infectious disease caused by a protozoan of the genus Plasmodium. Humans are mainly infected by P. falciparum, P. vivax, P. ovale and P. malariae. Around 44% of world's population is at risk from malaria. Malaria is one of the leading causes of morbidity and mortality in Ethiopia. The clinical features of malaria vary. The most characteristic symptom are fever, headache, lassitude, loss of appetite, muscle pain and chills, resulting in uncontrollable shivering with teeth chattering. Diagnosis of malaria is achieved by light microscopy, rapid diagnostic tests, polymerase chain reaction. Management of malaria includes general measures to be taken to save life of the person and prevention of recrudescence using drugs and other supportive measures. Parasite resistance to antimalarial medicines is a major threat to achieving malaria control and eventual elimination. The most important problem associated with the management of malaria are resistant to or is developing resistance to the most widely available, affordable and safest first line treatments. Prevention of malaria includes vector control to disrupt transmission from mosquito to human, prevention of infection and treatment after infection. V. amygdalina commonly called bitter leaf in English and 'Girawa' in Amharic. V. amygdalina has antimalarial properties and the aqueous extract of Vernonia amygdalina leaves exhibit antimalarial activity on P.falcifarum, P.vivax, P. ovale and P. malariae. Malaria is one of the life-threatening diseases. Moreover, Vernonia amygdalina can be used for the treatment of malaria in rural communities.

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Section: Etiologymentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

Review on Malaria and Antimalarial Activity of Vernonia Amygdalina in Ethiopia: A Review Article

Bihonegn¹

2019

JHMN

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“…People previously living in malaria endemic areas often acquire immunity to the local strains of malaria but once they move away, previous immunity is lost over time. 6…”

Section: Introductionmentioning

confidence: 99%

Artemether‐Lumefantrine and Primaquine for Mixed Plasmodium falciparum and ovale Malaria

Chan

2006

Pharmacy Practice and Res

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Aim: To present a case of uncomplicated mixed Plasmodium falciparum and ovale malaria requiring treatment with artemetherlumefantrine and primaquine. Clinical features: A 40-year-old female presented with a mixed infection of uncomplicated P. falciparum and ovale. Treatment was commenced with oral quinine sulphate 600 mg, 8-hourly which was changed to artemether-lumefantrine and primaquine. A glucose-6-phosphate-dehydrogenase test revealed deficiency, necessitating an alteration of the primaquine regimen. Discussion: Malaria infections are often initially treated with quinine if the infective species is not known or if the infection is mixed. Oral quinine remains useful in the treatment of uncomplicated P. falciparum malaria, however the six-dose regimen of artemether-lumefantrine is an effective alternative. Conclusion: This case highlights the benefits of artemetherlumefantrine for mixed-uncomplicated malaria and the use of primaquine for eradication of liver stages for P. ovale infections. J Pharm Pract Res 2006; 36: 134-5.

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Immune-Mediated Diseases: Where Do We Stand?

Shurin

Smolkin²

2007

Advances in Experimental Medicine and Biology

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Tackling Malaria

Cited by 5 publications

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Review on Malaria and Antimalarial Activity of Vernonia Amygdalina in Ethiopia: A Review Article

Review on Malaria and Antimalarial Activity of Vernonia Amygdalina in Ethiopia: A Review Article

Artemether‐Lumefantrine and Primaquine for Mixed Plasmodium falciparum and ovale Malaria

Immune-Mediated Diseases: Where Do We Stand?

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