Tackling hypertension via adrenal ablation - the development of novel immunohistochemical ablation biomarkers

Dennedy, Michael Conall; Prakash, Punit; O’Halloran, Martin; Eaton-Evans, Jimmy; Shahzad, Atif; Donlon, Padraig; Ruvio, Giuseppe

doi:10.1049/cp.2018.0783

Cited by 2 publications

(2 citation statements)

References 8 publications

(12 reference statements)

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“…Existing microwave ablation devices have been clinically applied for treating malignant tumors in the adrenal gland; however, the targeted tumors have typically been large (2.1-6.1 cm) [22][23][24][25]. Technological requirements and feasibility of microwave ablation of adrenal masses were investigated in [26,27]. For actively cooled applicators, adjustment of coolant flow parameters as well as coolant temperature may provide an additional means for adjusting ablation zone length.…”

Section: Introductionmentioning

confidence: 99%

Microwave antennas for thermal ablation of benign adrenal adenomas

Fallahi

Clausing

Shahzad

et al. 2019

Biomed. Phys. Eng. Express

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Microwave thermal ablation is under consideration as a minimally invasive modality to treat 10-20 mm benign adrenal adenomas, while preserving normally functioning adjacent adrenal tissue, and returning the gland to a normally functioning status that is under normal regulation. In contrast to applications for tumor ablation, where devices have been developed with the objective of maximizing the size of the ablation zone for treating large tumors, a challenge for adrenal ablation is to minimize thermal damage to non-targeted adrenal tissue and thereby preserve adrenal function. Here, we investigate methods for creating small spherical ablation zones of volumes in the range 0.5-4 cm 3 for the treatment of benign adrenal adenomas using water-loaded microwave monopole antennas operating at 2.45 GHz and 5.8 GHz. Coupled electromagnetic and bioheat transfer simulations and experiments in ex vivo tissue were employed to investigate the effect of frequency, applied power, ablation duration, and coolant temperature on the length and width of the ablation zone. Experimental results showed that small spherical ablation zones with diameters in the range of 7.4-17.6 mm can be obtained by adjusting the applied power and ablation duration. Multi-way ANOVA analysis of the experimentally-measured ablation zone dimensions demonstrated that frequency of operation and ablation duration are the primary parameters for controlling the ablation zone length and width, respectively. Additionally, it was demonstrated that the coolant temperature provides another effective parameter for controlling the ablation zone length without affecting the ablation zone width. Our study demonstrates the feasibility of creating small spherical microwave ablation zones suitable for targeting benign adrenal adenomas.

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Section: Introductionmentioning

confidence: 99%

Microwave antennas for thermal ablation of benign adrenal adenomas

Fallahi

Clausing

Shahzad

et al. 2019

Biomed. Phys. Eng. Express

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“…To address these limitations, MWA has emerged as a promising alternative for treating adrenal diseases. MWA uses a needle or stiff catheter to deliver microwave energy to the target area, causing coagulation necrosis by heating the surrounding tissue to temperatures above 50-60 ∘ C [11,12]. MWA offers several theoretical advantages over RFA, such as more precise targeting, efficient ablation, and a reduced risk of complications.…”

Section: Introductionmentioning

confidence: 99%

Adrenal ablation as a treatment for hypertension: analyzing the dielectric properties of adrenal glands for microwave ablation technologies

Amin,

Cappiello,

Kraśny

et al. 2023

Int. J. Microw. Wireless Technol.

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Adrenal gland-induced hypertension, also known as secondary hypertension, is a medical condition caused by an underlying adrenal pathology, most typically adrenocortical adenomas. Current clinical practices involve pharmacotherapy or surgical resection to treat adrenal gland diseases that cause hypertension. However, due to the limitations of these treatment options, microwave ablation (MWA) has emerged as a promising minimally invasive alternative. An accurate understanding of the dielectric properties of adrenal glands would support the further development and optimization of MWA technology for treating adrenal tumors. Only a few studies have examined the dielectric properties of both human and animal adrenal glands, and the sample sizes of these studies have been relatively small. Therefore, further dielectric data of human and animal adrenal glands are warranted. This paper presents the ex vivo dielectric properties of the ovine adrenal glands (medulla and cortex) and summarizes the published literature on dielectric data of adrenal glands from porcine, bovine, ovine, and human samples in the microwave frequency range to analyze the consistency and reliability of the reported data. The dielectric properties of the ovine adrenal glands (N = 8) were measured using an open-ended coaxial probe measurement technique at frequencies ranging from 0.5 to 8.5 GHz. This study also investigated the temperature-dependent dielectric properties of the ovine adrenal medulla ranging from 37 to 64°C at frequencies ranging from 0.5 to 8.5 GHz. The dielectric properties of the ovine adrenal medulla measured in this study were found to be consistent with the literature. Moreover, the review suggests that variations exist in the dielectric properties of the adrenal medulla and cortex among species. The study also found that the dielectric properties of the adrenal medulla decrease with increasing temperature, similar to other tissues for which temperature-dependent dielectric data have been reported. This summary of dielectric data of adrenal glands and the temperature-dependent dielectric properties of the ovine adrenal medulla will accelerate the development of MWA technologies for hypertension treatment.

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Tackling hypertension via adrenal ablation - the development of novel immunohistochemical ablation biomarkers

Abstract: Some of the authors of this publication are also working on these related projects: Non-invasive measurement View project Urinary Bladder Monitoring using Electrical Impedance View project

Cited by 2 publications

References 8 publications

Microwave antennas for thermal ablation of benign adrenal adenomas

Microwave antennas for thermal ablation of benign adrenal adenomas

Adrenal ablation as a treatment for hypertension: analyzing the dielectric properties of adrenal glands for microwave ablation technologies

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