“…Moreover, healthcare systems in Japan were strained to the limits due to the newest COVID-19 XBB variants, approaching the threshold where the medical care system would face a potential collapse, highlighting the disproportionate burden of COVID-19 on under-resourced healthcare systems and the ongoing need for innovative treatment modalities (3). Furthermore, the phenomenon of long COVID, a post-acute sequelae with a range of persistent symptoms, has emerged as a new challenge, further emphasizing the need for innovative therapeutic approaches (4).…”