Tacit Pledges

Hill, Geoffrey E.

doi:10.1007/978-1-349-62279-5_4

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Metastatic melanoma is the most aggressive form of skin cancer, with approximately 13,000 annual deaths and a median overall survival (OS) of 8 to 18 months [1,4]. FDA approved therapies for metastatic melanoma, such as dacarbazine and high dose interleukin 2 (HD IL-2), is limited by a low response rate (6 % to 15 %) and high toxicity for only a minority of patients [12,13]. Ipilimumab, a fully human IgG1 monoclonal antibody that blocks CTLA-4, increasing T-cell activity and promoting antitumor ac- 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 tivity, has been approved by FDA to target chemotherapy-resistant, advanced solid tumors, especially melanoma [6].…”

Section: Discussionmentioning

confidence: 99%

Treatment of advanced melanoma with laser immunotherapy and ipilimumab

Naylor

Zhou

Geister

et al. 2017

Journal of Biophotonics

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Immunotherapy has become a promising modality for melanoma, especially using checkpoint inhibitors, which revive suppressed T cells against the cancer. Such inhibitors should work better when combined with other treatments which could increase the number and quality of anti-tumor T cells. We treated one patient with advanced (stage IV) melanoma, using the combination of laser immunotherapy (LIT), a novel immunological approach for metastatic cancers that has been shown to stimulate adaptive immunity, and ipilimumab. The patient was treated with LIT, followed with one course of ipilimumab 3 months after the beginning of LIT. After LIT treatment, all treated cutaneous melanoma in head and neck cleared completely. After the application of ipilimumab, all the tumor nodules in the lungs decreased. The patient had remained tumor free for one year. While anecdotal, the responses seen in this patient support the hypothesis that laser immunotherapy increases the number and quality of anti-tumor T cells so that ipilimumab and other checkpoint inhibitors are more effective in enhancing the therapeutic effects. Picture: Schematic of treatment using laser immunotherapy and ipilimumab on a stage IV melanoma patient.

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Section: Discussionmentioning

confidence: 99%

Treatment of advanced melanoma with laser immunotherapy and ipilimumab

Naylor

Zhou

Geister

et al. 2017

Journal of Biophotonics

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“…Indeed, the expected damage mechanisms of such materials may be linked to a reduced number of AE sources, essentially associated with the nucleation and propagation of cracks. Oppositely, the source mechanisms expected during damage growth in composites are numerous, including matrix cracking, fibre-matrix interface debonding, fibre rupture and delamination [52][53][54][55][56]. Also, a need arises to study materials whose microstructural parameters can be easily adjusted: exploring the effect of various parameters on the fracture behaviour is indeed essential.…”

Section: Introductionmentioning

confidence: 99%

Mechanical response and fracture dynamics of polymeric foams

Deschanel¹,

Vanel²,

Godin³

et al. 2009

J. Phys. D: Appl. Phys.

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Heterogeneous materials usually break through a process of microcracking that eventually leads to final rupture after accumulation and coalescence of many microcracks. The statistical properties of microcracking rupture have been known to resemble critical point statistics, with many of the physical quantities obeying power law distributions. However, there is no clear understanding of the origin of these distributions and of the specific values observed for the power law exponents. In this paper, we review the special case of polymeric foams that have the advantage of containing a single material component, the polymer, as opposed to usual heterogeneous materials such as composites. First, we review briefly the typical features of the polymeric foam mechanical response up to rupture that have been studied a lot previously. Then, we focus on a less-well-known aspect: the rupture dynamics of polymeric foams. We show that not only polymeric foams behave like other heterogeneous materials, i.e. they display power law statistics, but also, we are able to test the effect on the power laws of the following properties: the foam heterogeneity by changing its density, the foam mechanical response by changing its temperature and the mechanical history by comparing creep tests and tensile tests.

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Tacit Pledges

Cited by 2 publications

References 2 publications

Treatment of advanced melanoma with laser immunotherapy and ipilimumab

Treatment of advanced melanoma with laser immunotherapy and ipilimumab

Mechanical response and fracture dynamics of polymeric foams

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