Tachykinins and Hematopoiesis

Liu, Katherine; Castillo, Marianne D.; Murthy, Raghav G.; Patel, Nitixa; Rameshwar, Pranela

doi:10.1016/j.cca.2007.07.008

Cited by 20 publications

(20 citation statements)

References 54 publications

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“…In addition to neural crest derivatives, neurotrophic factors and neuropeptides, released by innervating nerve fibers and surrounding cells, have also been suggested to participate in formation of hematopoietic environment in the bone marrow (Liu et al, 2007). For instance, substance P and neurokinin-A, a tachykinin family neuropeptides, have been suggested to stimulate production of hematopoietic cytokines by BM stromal cells as well as serving as essential modulators of both normal and malignant hematopoiesis (Nowicki et al, 2007).…”

Section: Neural Regulation Of Hematopoiesismentioning

confidence: 99%

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Hanoun

Maryanovich

Arnal-Estapé

et al. 2015

Neuron

193

163

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Although the function of the autonomic nervous system (ANS) in mediating the “flight-or-fight” response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem cell niche homeostasis, regeneration and fine-tunes the inflammatory response. Additionally, emerging data suggest that cancer cells take advantage of innervating neural circuitry to promote their progression. These new discoveries outline the need to redesign therapeutic strategies to target this underappreciated stromal constituent. Here, we review the importance of neural signaling in hematopoietic homeostasis, inflammation and cancer.

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Section: Neural Regulation Of Hematopoiesismentioning

confidence: 99%

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Hanoun

Maryanovich

Arnal-Estapé

et al. 2015

Neuron

193

163

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“…9 In the mid-1980s, NKA and NKB were identified by multiple groups, [10][11][12] and since then, tachykinins have been extensively studied for their roles in many pathological and physiological processes, including hematopoiesis. 13 The three known genes that encode mammalian tachykinins are TAC1, TAC3, and TAC4, also termed as preprotachykinin A (PPT-A), -B (PPT-B), and -C (PPT-C), respectively. 7 TAC1 encodes SP, NKA, and the extended forms of NKA (NPK and NPγ).…”

Section: Tachykininsmentioning

confidence: 99%

“…34 Regarding hematopoietic cells, NK1 and NK2 expression has been established in mature immune cells, hematopoietic progenitors, mesenchymal stem cells (MSCs) and BM stroma. 13,19 Reports of tachykinin-mediated processes which seem to be NK receptor-independent, 40 and the recent identification of novel tachykinins 22 have reopened the question about the existence of a fourth NK receptor. While attempts to find additional NK receptors have been unsuccessful, the question remains a focal point due to the identification of tachykinins that appear to interact with receptors other than those of the NK family; and crosstalk between NK receptor subtypes in human models of hematopoiesis.…”

Section: Neurokinin Receptorsmentioning

confidence: 99%

Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link

Klassert

Patel²,

Rameshwar³

2010

JRLCR

Self Cite

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After many decades of neuropeptide research, advances in the field of tachykinins have considerably increased and revealed their implications in several physiological processes. In this review we focus on the role of the tachykinins in the regulation of hematopoietic functions. Evidence has shown that neural control of this process is emerging as a significant category in hematopoietic modulation. In the context of this regulation, we discuss the existence of a complex network involving the neurokinin receptors, tachykinins and cytokines. This network is tightly regulated by each of its components.

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“…Among neuropeptides that are involved in the hematopoetic process, the role of tachykinins, especially Substance P (SP), have been almost characterized (Liu et al 2007). There are evidences showing bone marrow (BM) innervations by SP as well as its release from BM resident cells (Hiramoto et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Substance P and calcitonin gene-related neuropeptides as novel growth factors forex vivoexpansion of cord blood CD34⁺hematopoietic stem cells

Shahrokhi¹,

Ebtekar²,

Pourfathollah³

et al. 2009

Growth Factors

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There is little evidence on roles of growth factors other than cytokines in expansion of cord blood (CB) stem cells. We aimed to explore a novel approach for expansion, using Substance P (SP) and calcitonin gene-related peptide (CGRP) neuropeptides. CB CD34(+) cells were cultured in different concentrations of SP and/or CGRP in combination with a cytokine cocktail. Phenotypic and functional analysis was performed by flowcytometry and colonogenic assay. Our results show a significant improvement of total expansion of neuropeptide treated cells. There was a selective effect of CGRP on CD34(+) CD133(+) cells, SP on CD34(+) CD45(dim) cells, and 10(- 9) M SP and/or CGRP on expansion of CD34(+) CD38(- ) cells. There was also a tendency for erythroid and granulocyte-myeloid colony formation in SP and CGRP treated cultures, respectively. Supplementation of cytokines with other growth factors, such as neuropeptides, might enable us to overcome the difficulties of ex vivo expansion of CB cells.

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Tachykinins and Hematopoiesis

Cited by 20 publications

References 54 publications

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link

Substance P and calcitonin gene-related neuropeptides as novel growth factors forex vivoexpansion of cord blood CD34⁺hematopoietic stem cells

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Tachykinins and Hematopoiesis

Cited by 20 publications

References 54 publications

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Tachykinins and neurokinin receptors in bone marrow functions: neural-hematopoietic link

Substance P and calcitonin gene-related neuropeptides as novel growth factors forex vivoexpansion of cord blood CD34+hematopoietic stem cells

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Product

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Substance P and calcitonin gene-related neuropeptides as novel growth factors forex vivoexpansion of cord blood CD34⁺hematopoietic stem cells