Tachykinin NK2 antagonist for treatments of various disease states

Jung, Hyun Jin; Priefer, Ronny

doi:10.1016/j.autneu.2021.102865

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…NKB is a polypeptide encoded by Tac2 encoded by Tac1 ( 62 ). NKA and NKB are also endogenous ligands for NK2 receptors which are distributed in the pharynx, larynx, trachea, bronchi, and lung organs ( 63 ). NkA is responsible for transmembrane electrochemical gradients, determining intracellular ion homeostasis, metabolite transport, and regulation of intercellular and intracellular signals; so, its downregulation is related to the formation of many diseases, including asthma and allergic diseases ( 64 ).…”

Section: Substances Secreted By Pulmonary Neuroendocrine Cells Act As...mentioning

confidence: 99%

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

et al. 2022

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Asthma is a complex syndrome with polygenetic tendency and multiple phenotypes, which has variable expiratory airflow limitation and respiratory symptoms that vary over time and in intensity. In recent years, continuous industrial development has seriously impacted the climate and air quality at a global scale. It has been verified that climate change can induce asthma in predisposed individuals and that atmospheric pollution can exacerbate asthma severity. At present, a subset of patients is resistant to the drug therapy for asthma. Hence, it is urgent to find new ideas for asthma prevention and treatment. In this review, we discuss the prescription, composition, formulation, and mechanism of traditional Chinese medicine monomer, traditional Chinese medicine monomer complex, single herbs, and traditional Chinese patent medicine in the treatment of asthma. We also discuss the effects of Chinese herbal medicine on asthma from the perspective of cellular endocrinology in the past decade, emphasizing on the roles as intracellular and extracellular messengers of three substances—hormones, substances secreted by pulmonary neuroendocrine cells, and neuroendocrine-related signaling protein—which provide the theoretical basis for clinical application and new drug development.

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Section: Substances Secreted By Pulmonary Neuroendocrine Cells Act As...mentioning

confidence: 99%

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

et al. 2022

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“…The prevalence of constipation is estimated to be approximately 15% globally [1]. In particular, previous studies have reported that irritable bowel syndrome (IBS) with predominant constipation (IBS-C) is associated with abnormal motility, and it is characterized by an imbalance between segmentation and propulsion [2,3]. Similarly to some Western studies, many colon transit studies in Asian patients with IBS have reported that patients with IBS-C generally have delayed colon transit [4].…”

Section: Introductionmentioning

confidence: 99%

Stimulus–Response Plots as a Novel Bowel-Sound-Based Method for Evaluating Motor Response to Drinking in Healthy People

Haraguchi,

Emoto

2024

Sensors

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Constipation is a common gastrointestinal disorder that impairs quality of life. Evaluating bowel motility via traditional methods, such as MRI and radiography, is expensive and inconvenient. Bowel sound (BS) analysis has been proposed as an alternative, with BS-time-domain acoustic features (BSTDAFs) being effective for evaluating bowel motility via several food and drink consumption tests. However, the effect of BSTDAFs before drink consumption on those after drink consumption is yet to be investigated. This study used BS-based stimulus–response plots (BSSRPs) to investigate this effect on 20 participants who underwent drinking tests. A strong negative correlation was observed between the number of BSs per minute before carbonated water consumption and the ratio of that before and after carbonated water consumption. However, a similar trend was not observed when the participants drank cold water. These findings suggest that when carbonated water is drunk, bowel motility before ingestion affects motor response to ingestion. This study provides a non-invasive BS-based approach for evaluating motor response to food and drink, offering a new research window for investigators in this field.

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Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain

Borbély,

Pethő

2024

Current Opinion in Pharmacology

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Tachykinin NK2 antagonist for treatments of various disease states

Cited by 3 publications

References 49 publications

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

Stimulus–Response Plots as a Novel Bowel-Sound-Based Method for Evaluating Motor Response to Drinking in Healthy People

Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain

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