Tachykinin Antagonists Reverse Ischemia/Reperfusion Gastrointestinal Motility Impairment in Rats

Umer, Artur; Ługowska-Umer, Hanna; Schönborn‐Kellenberger, Oliver; Korolkiewicz, Paweł Konstanty; Sein-Anand, Łukasz; Krzemieniecki, Krzysztof; Korolkiewicz, Roman

doi:10.1016/j.jss.2020.05.092

Cited by 2 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the above, the most effective doses of NK 1‐3 antagonists have not affected the intestinal propulsion in untreated rats or animals exposed to skin incision. These data are similar to results previously published by our group [6,15], and thus in order to avoid duplications, were not shown. In the case of laparotomy, NK 1‐2 proved to be ineffective, whereas the submaximal and maximum dose of NK 3 showed a reversal when the effect of laparotomy is concerned.…”

Section: Resultssupporting

confidence: 92%

“…The decreased intestinal transit caused by laparotomy with a subsequent surgical gut manipulation recovered gradually in a time‐dependent manner from 24 to 144 h post‐surgery, amounting to 17 ± 4 cm and 85 ± 19 cm, respectively ( Figure ). For the sake of clarity and because the trends concerning the intestinal passage in untreated and ether‐anesthetized animals were similar to the one previously published [6,10,11,15], the results were not presented graphically in Figure .…”

Section: Resultsmentioning

confidence: 98%

“…Tachykinins modulate many GI functions including motor activity, mucosal water and ion transportation, and the immune and inflammatory reactions [4,5]. It has been demonstrated that the pretreatment with potent, synthetic NK 1‐3 blockers reversed in a dose‐dependent manner the inhbition of GI motility evoked by ischemia–reperfusion injury [15,16].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Tachykinin antagonists ameliorate surgically induced impairment of gastrointestinal motility in rats

Umer

Ługowska-Umer

Schönborn‐Kellenberger³

et al. 2020

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

The protective effects of tachykinin receptor antagonists: SR140333 (NK1 receptor), SR48968 (NK2 receptor), and SB222200 (NK3 receptor) were tested in rats against a surgically induced postoperative inhibition of gut motility, a common complication of abdominal surgery. The small intestinal transit of Evans blue was measured 24‐h post‐surgery in untreated rats and animals subjected to skin incision, laparotomy, or laparotomy followed by gut evisceration and manipulation. Surgical procedures were conducted under diethyl ether anesthesia. In comparison to untreated and ether‐anesthetized rats, animals undergoing skin incision, laparotomy, or laparotomy with gut evisceration and manipulation showed a significant decrease in the intestinal transit of Evans blue. The pretreatment with NK1 (3–100 µg/kg), NK2 (3–30 µg/kg), and NK3 (10–300 µg/kg) blockers before surgery ameliorated the inhibitory effects of gut manipulation in a dose‐dependent manner. Moreover, the submaximal and maximal doses of NK3 antagonists showed a trend toward reversing not only the inhibition caused by gut manipulation but also laparotomy. An additive effect of combining submaximal doses of NK1‐3 blockers was observed in animals pretreated with NK1 + NK2 compared to single‐agent NK1 and NK2. Additionally, doublets: NK1 + NK3 or NK2 + NK3 and a triplet: NK1 + NK2 + NK3 proved to be more effective than NK2 antagonist alone. In contrast, NK1‐3 blockers have not markedly affected the intestinal propulsion in untreated rats or animals subjected to skin incision or laparotomy. NK1‐3 blockers ameliorated the suppressed small‐bowel gut motility 24 post‐surgery. Combined pretreatment with NK1‐3 antagonists provided selective, additive benefits compared to single agents.

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 98%