2012
DOI: 10.1093/icvts/ivs085
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TachoSil(R) for postinfarction ventricular free wall rupture

Abstract: Despite a decline in the last three decades, postinfarction ventricular free wall rupture still complicates more than 3% of acute ST-elevation myocardial infarctions and remains a surgical challenge. TachoSil (Nycomed, Zurich, Switzerland) is an equine collagen patch coated with human fibrinogen and human thrombin, which has recently been used for haemostasis in cardiovascular surgery, but its potential usefulness in free wall rupture has not been reported. Initial clinical experience with an on-pump sutureles… Show more

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Cited by 32 publications
(21 citation statements)
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“…Many surgeons have recently reported that sutureless repair using TachoSil sheets can efficiently achieve hemostasis [1], [2], [3]. However, this strategy is not always suitable for ruptures, where the myocardial tear is often large and bleeding is copious [1], [4].…”
Section: Discussionmentioning
confidence: 99%
“…Many surgeons have recently reported that sutureless repair using TachoSil sheets can efficiently achieve hemostasis [1], [2], [3]. However, this strategy is not always suitable for ruptures, where the myocardial tear is often large and bleeding is copious [1], [4].…”
Section: Discussionmentioning
confidence: 99%
“…To ensure a better hold, the fibrin fleece should be placed over the margin of the infarction zone. Fibrin fleeces are used successfully in cardiac surgeries [18,19,36,[38][39][40][41][42].…”
Section: Emergency Surgerymentioning
confidence: 99%
“…For additional stabilization of the vulnerable myocardium area, a bovine patch was placed (Tutomesh®) on the damaged ventricle, which should also prevent the formation of a pseudoaneurysm [4,18,35,37,40,43]. Because of the migration of fibroblasts into the patch and the angioneogenesis the patch was replaced through a collagen tissue.…”
Section: Emergency Surgerymentioning
confidence: 99%
“…Side effects were similar for both treatment groups [25]. TachoSil fibrin glue has also been shown to be effective in patients with acute myocardial infarction involving pulmonary bypass [26]. …”
Section: Sealantsmentioning
confidence: 99%