Tache Noire in a Patient with Acute Q Fever

Fiore, Vito; Mancini, Fabiola; Ciervo, Alessandra; Bagella, Paola; Peruzzu, Francesca; Nunnari, Giuseppe; Deiana, Giovanni; Rezza, Giovanni; Babudieri, Sergio; Madeddu, Giordano

doi:10.1159/000486573

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…However, several atypical cases of infectious diseases transmitted by zoonotic agents have been described in the literature [1-3]. For example, a case of tache noire in a patient with Q fever was reported recently [4]. …”

Section: Discussionmentioning

confidence: 99%

Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever

Baltadzhiev

Popivanova

2018

Med Princ Pract

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Objective: To report a rare case of maculopapular rash on the scalp in a patient with Mediterranean spotted fever (MSF). Clinical Presentation and Intervention: A 58-year-old woman with breast cancer and chemotherapy-induced alopecia contracted MSF. Her clinical features were typical, except for a maculopapular rash covering the scalp. The diagnosis of MSF was confirmed by immunofluorescent assay. The disease had a favorable course and the patient was discharged in good condition. Conclusion: The rash on the scalp described in this report enriches our knowledge on the clinical characteristics of MSF.

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Section: Discussionmentioning

confidence: 99%

Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever

Baltadzhiev

Popivanova

2018

Med Princ Pract

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“…However, clinical cases in which the tache noir was present in other zoonoses have been reported in the literature. 108 – 110 …”

Section: Clinical Manifestationmentioning

confidence: 99%

“…However, clinical cases in which the tache noir was present in other zoonoses have been reported in the literature. [108][109][110] The presence of fever without other signs is, probably, the most difficult challenge for clinicians because it is the expression of many diseases, both infective (bacterial, viral, fungal, and parasitic) and not infective. In these patients, a proper anamnesis, laboratory findings, and radiological features are mandatory to permit the correct diagnosis.…”

mentioning

confidence: 99%

Epidemiology, Clinical Aspectes,laboratory Diagnosis and Treatment of Rickesial Diseases in the Mediterranean Area Durin Covid-19 Pandemic:a Review of the Literature

Vito

Geremia

Mameli

et al. 2020

Mediterr J Hematol Infect Dis

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The purpose of the present review is to give an update regarding the classification, the epidemiology, the clinical manifestation, the diagnoses, and the treatment of the Rickettsiae species present in the Mediterranean area. We performed a comprehensive search, through electronic databases (Pubmed – MEDLINE) and search engines (Google Scholar), of peer-reviewed publications (articles, reviews, and books). The availability of new diagnostic tools, including Polymerase Chain Reaction and nucleotide sequencing has significantly modified the classification of intracellular bacteria, including the order Rickettsiales with more and more new Rickettsia species recognized as human pathogens. Furthermore, emerging Rickettsia species have been found in several countries and are often associated with unique clinical pictures that may challenge the physician in the early detection of the diseases. Rickettsial infections include a wide spectrum of clinical presentations ranging from a benign to a potentially life treating disease that requires prompt recognition and proper management. Recently, due to the spread of SARS-CoV-2 infection, the differential diagnosis with COVID-19 is of crucial importance. The correct understanding of the clinical features, diagnostic tools, and proper treatment can assist clinicians in the management of Rickettsioses in the Mediterranean area.

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“…), and maculopapular rash on the body and extremities, not sparing the palms and feet [2, 6]. As with other infectious diseases, atypical forms have also been reported [7, 8]. MSF has usually a mild or moderate course and has long been considered a benign disease; however, severe forms including major neurological manifestations and multiorgan involvement may occur [9].…”

Section: Introductionmentioning

confidence: 99%

Renal Involvement in Mediterranean Spotted Fever: Clinical and Histopathological Data

2021

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Background: Mediterranean spotted fever (MSF) is a tick-borne rickettsial infection endemic to the Mediterranean coastline countries. As a result of growing tourism imported cases have been registered in many non-endemic countries and regions. Objective: We present clinical laboratory parameters and histopathological data on renal impairment in patients with MSF. The study meets our goal of identifying kidney involvement and detecting renal damage in people with MSF. Subjects and Methods: 350 patients with MSF with a diagnosis confirmed by immunofluorescence analysis were tested for serum urea, creatinine and albumin. Fifty five patients with malignant form of MSF were divided into two groups: 19 fatalities and 36 survivors. The percentage of patients with acute renal failure (ARF) was compared in both groups. Results: Subjects with elevated urea and creatinine levels increased from 5.21% and 3.47% in mild to 48.78% and 29.26% in severe MSF, respectively. Loss of serum albumin also increased from mild to severe MSF. Renal impairment comprised 60% of the cohort of 55 patients with malignant MSF: 89.4% in the group of deaths, and almost twice less in the survivors. ARF developed in 84.2% of fatal cases and was more than two times less in survivors. The postmortem performed light microscopy of renal samples of 9 fatal cases revealed perivascular mononuclear inflammatory infiltrates, vasculitis with fibrinoid necrosis, acute tubular necrosis, interstitial edema, hemorrhage and thrombosis. Conclusion: Renal pathology associated with MSF rickettsial infection consists of systemic small vessel vasculitis and vascular injury leading to ARF in the most severe cases.

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Tache Noire in a Patient with Acute Q Fever

Cited by 4 publications

References 9 publications

Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever

Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever

Epidemiology, Clinical Aspectes,laboratory Diagnosis and Treatment of Rickesial Diseases in the Mediterranean Area Durin Covid-19 Pandemic:a Review of the Literature

Renal Involvement in Mediterranean Spotted Fever: Clinical and Histopathological Data

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