Taccalonolides from tacca plantaginea

Shen, Ji-Hui; Chen, Zhongliang; Yi-sheng, Gao

doi:10.1016/0031-9422(95)00972-8

Cited by 23 publications

(3 citation statements)

References 3 publications

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“…These plants are primarily found in tropical regions of South America, Africa, Australia, Southeast Asia, and various oceanic islands. Within this genus, there are several species that contain a diverse range of highly oxygenated ixocarpalactone-type withanolides [ 89 , 90 , 91 , 92 , 93 , 94 , 95 ]. One notable example of these withanolides is taccalonolide A ( 127 ) along with its analog taccalonolide L ( 128 ) [ 89 ].…”

Section: Miscellaneous Steroids With αβ-Epoxy Group Derived From Diff...mentioning

confidence: 99%

“…The chemical structure of taccalonolide L can be seen in Figure 26 , and its biological activity is detailed in Table 9 . Extracts from Tacca plantaginea T. paxiana T. subflabellata , and T. plantaginea have been found to contain over 20 different withanolides, including compounds such as 128 , 129 , taccalonolide M, 130 , taccalonolide G, 131 , taccalonolide H, 132 , taccalonolide Q, and 133 , taccalonolide Y [ 90 , 91 , 92 , 93 , 94 ].…”

Section: Miscellaneous Steroids With αβ-Epoxy Group Derived From Diff...mentioning

confidence: 99%

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Bioactive Steroids Bearing Oxirane Ring

Dembitsky

2023

Biomedicines

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This review explores the biological activity and structural diversity of steroids and related isoprenoid lipids, with a particular focus on compounds containing an oxirane ring. These natural compounds are derived from fungi, fungal endophytes, as well as extracts of plants, algae, and marine invertebrates. To evaluate their biological activity, an extensive examination of refereed literature sources was conducted, including in vivo and in vitro studies and the utilization of the QSAR method. Notable properties observed among these compounds include strong anti-inflammatory, antineoplastic, antiproliferative, anti-hypercholesterolemic, antiparkinsonian, diuretic, anti-eczematic, anti-psoriatic, and various other activities. Throughout this review, 3D graphs illustrating the activity of individual steroids are presented, accompanied by images of selected terrestrial or marine organisms. Furthermore, this review provides explanations for specific types of biological activity associated with these compounds. The data presented in this review are of scientific interest to the academic community and carry practical implications in the fields of pharmacology and medicine. By analyzing the biological activity and structural diversity of steroids and related isoprenoid lipids, this review offers valuable insights that contribute to both theoretical understanding and applied research. This review draws upon data from various authors to compile information on the biological activity of natural steroids containing an oxirane ring.

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Section: Miscellaneous Steroids With αβ-Epoxy Group Derived From Diff...mentioning

confidence: 99%

Section: Miscellaneous Steroids With αβ-Epoxy Group Derived From Diff...mentioning

confidence: 99%

Bioactive Steroids Bearing Oxirane Ring

Dembitsky

2023

Biomedicines

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“…Chemical structures 265-272 are shown in Figure 20, and their biological activity is shown in Table 18. Carbon-bridged steroids, related to taccalonolide A, were isolated from Tacca plantaginea, Tacca subflaellata, and the Vietnamese plant Tacca paxiana [234][235][236][237][238]. Taccalonolides AF (272) and AJ (273), showing antiproliferative properties, were isolated from a fraction of an ethanol extract of T. plantaginea [239], and a carbon-bridged steroid, named physanolide A (274), with an unprecedented skeleton containing a seven-membered ring was isolated from Physalis angulate [240].…”

Section: Miscellaneous Cyclosteroids and Triterpenoids Derived From Marine And Terrestrial Sourcesmentioning

confidence: 99%

Antitumor Profile of Carbon-Bridged Steroids (CBS) and Triterpenoids

2021

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This review focuses on the rare group of carbon-bridged steroids (CBS) and triterpenoids found in various natural sources such as green, yellow-green, and red algae, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in amoebas, fungi, fungal endophytes, and plants. For convenience, the presented CBS and triterpenoids are divided into four groups, which include: (a) CBS and triterpenoids containing a cyclopropane group; (b) CBS and triterpenoids with cyclopropane ring in the side chain; (c) CBS and triterpenoids containing a cyclobutane group; (d) CBS and triterpenoids containing cyclopentane, cyclohexane or cycloheptane moieties. For the comparative characterization of the antitumor profile, we have added several semi- and synthetic CBS and triterpenoids, with various additional rings, to identify possible promising sources for pharmacologists and the pharmaceutical industry. About 300 CBS and triterpenoids are presented in this review, which demonstrate a wide range of biological activities, but the most pronounced antitumor profile. The review summarizes biological activities both determined experimentally and estimated using the well-known PASS software. According to the data obtained, two-thirds of CBS and triterpenoids show moderate activity levels with a confidence level of 70 to 90%; however, one third of these lipids demonstrate strong antitumor activity with a confidence level exceeding 90%. Several CBS and triterpenoids, from different lipid groups, demonstrate selective action on different types of tumor cells such as renal cancer, sarcoma, pancreatic cancer, prostate cancer, lymphocytic leukemia, myeloid leukemia, liver cancer, and genitourinary cancer with varying degrees of confidence. In addition, the review presents graphical images of the antitumor profile of both individual CBS and triterpenoids groups and individual compounds.

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